SZGR2

Summary ?

GeneID	9470
Symbol	EIF4E2
Synonyms	4E-LP\|4EHP\|EIF4EL3\|IF4e
Description	eukaryotic translation initiation factor 4E family member 2
Reference	MIM:605895\|HGNC:HGNC:3293\|Ensembl:ENSG00000135930\|HPRD:05798\|Vega:OTTHUMG00000133256
Gene type	protein-coding
Map location	2q37.1
Pascal p-value	0.049
Sherlock p-value	0.467
Fetal beta	0.572
DMG	1 (# studies)
eGene	Caudate basal ganglia Cortex Putamen basal ganglia

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg15779458	2	233415951	EIF4E2	1.07E-8	-0.024	4.57E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs1190453	2	233417312	EIF4E2	ENSG00000135930.9	7.725E-7	0.01	1796	gtex_brain_putamen_basal
rs34854862	2	233417394	EIF4E2	ENSG00000135930.9	2.829E-6	0.01	1878	gtex_brain_putamen_basal
rs1190452	2	233417552	EIF4E2	ENSG00000135930.9	1.025E-6	0.01	2036	gtex_brain_putamen_basal
rs377195442	2	233417932	EIF4E2	ENSG00000135930.9	1.276E-6	0.01	2416	gtex_brain_putamen_basal
rs1190451	2	233418288	EIF4E2	ENSG00000135930.9	1.746E-6	0.01	2772	gtex_brain_putamen_basal
rs1190450	2	233418302	EIF4E2	ENSG00000135930.9	1.745E-6	0.01	2786	gtex_brain_putamen_basal
rs11381056	2	233418578	EIF4E2	ENSG00000135930.9	5.455E-7	0.01	3062	gtex_brain_putamen_basal
rs1190448	2	233419084	EIF4E2	ENSG00000135930.9	1.63E-6	0.01	3568	gtex_brain_putamen_basal
rs1201451	2	233419396	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	3880	gtex_brain_putamen_basal
rs1307667	2	233419972	EIF4E2	ENSG00000135930.9	1.52E-6	0.01	4456	gtex_brain_putamen_basal
rs1190447	2	233420052	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	4536	gtex_brain_putamen_basal
rs201284540	2	233420652	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	5136	gtex_brain_putamen_basal
rs1190445	2	233420827	EIF4E2	ENSG00000135930.9	1.516E-6	0.01	5311	gtex_brain_putamen_basal
rs397740637	2	233421284	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	5768	gtex_brain_putamen_basal
rs1729245	2	233424891	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	9375	gtex_brain_putamen_basal
rs1550096	2	233428385	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	12869	gtex_brain_putamen_basal
rs13394993	2	233437268	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	21752	gtex_brain_putamen_basal
rs2293338	2	233438786	EIF4E2	ENSG00000135930.9	1.782E-6	0.01	23270	gtex_brain_putamen_basal
rs10185980	2	233439851	EIF4E2	ENSG00000135930.9	1.775E-6	0.01	24335	gtex_brain_putamen_basal
rs12617363	2	233440296	EIF4E2	ENSG00000135930.9	7.74E-7	0.01	24780	gtex_brain_putamen_basal
rs62191571	2	233440756	EIF4E2	ENSG00000135930.9	8.996E-7	0.01	25240	gtex_brain_putamen_basal
rs7571154	2	233440924	EIF4E2	ENSG00000135930.9	7.24E-7	0.01	25408	gtex_brain_putamen_basal
rs7571716	2	233441420	EIF4E2	ENSG00000135930.9	7.781E-7	0.01	25904	gtex_brain_putamen_basal
rs13393692	2	233442016	EIF4E2	ENSG00000135930.9	1.07E-6	0.01	26500	gtex_brain_putamen_basal
rs13393800	2	233442091	EIF4E2	ENSG00000135930.9	7.735E-7	0.01	26575	gtex_brain_putamen_basal
rs3841083	2	233446259	EIF4E2	ENSG00000135930.9	7.587E-7	0.01	30743	gtex_brain_putamen_basal
rs72243817	2	233448850	EIF4E2	ENSG00000135930.9	7.883E-7	0.01	33334	gtex_brain_putamen_basal
rs12620925	2	233450820	EIF4E2	ENSG00000135930.9	1.72E-7	0.01	35304	gtex_brain_putamen_basal
rs12617649	2	233450824	EIF4E2	ENSG00000135930.9	1.72E-7	0.01	35308	gtex_brain_putamen_basal
rs2276559	2	233451163	EIF4E2	ENSG00000135930.9	4.718E-7	0.01	35647	gtex_brain_putamen_basal
rs60029373	2	233456262	EIF4E2	ENSG00000135930.9	6.042E-7	0.01	40746	gtex_brain_putamen_basal
rs4468805	2	233459663	EIF4E2	ENSG00000135930.9	1.601E-7	0.01	44147	gtex_brain_putamen_basal
rs4555341	2	233459738	EIF4E2	ENSG00000135930.9	1.643E-7	0.01	44222	gtex_brain_putamen_basal
rs10193553	2	233459862	EIF4E2	ENSG00000135930.9	1.739E-7	0.01	44346	gtex_brain_putamen_basal
rs9808024	2	233462273	EIF4E2	ENSG00000135930.9	3.161E-6	0.01	46757	gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MTOR SIGNALING PATHWAY	52	40	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION DN	36	23	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN	411	249	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN	135	88	All SZGR 2.0 genes in this pathway
RAMASWAMY METASTASIS UP	66	43	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE	346	192	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17	181	101	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway

Gene Page: EIF4E2