Gene Page: BAG3

Summary ?
GeneID9531
SymbolBAG3
SynonymsBAG-3|BIS|CAIR-1|MFM6
DescriptionBCL2 associated athanogene 3
ReferenceMIM:603883|HGNC:HGNC:939|Ensembl:ENSG00000151929|HPRD:04860|Vega:OTTHUMG00000019155
Gene typeprotein-coding
Map location10q25.2-q26.2
Pascal p-value0.319
Sherlock p-value0.433
Fetal beta-1.837
eGeneMyers' cis & trans
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10520238chr4173525310BAG395310.06trans
snp_a-20845180BAG395310.06trans
rs7706288chr5141864248BAG395310.1trans
rs2700772chr85837584BAG395310.11trans
rs2700770chr85837808BAG395310.11trans
rs108425570BAG395310.02trans
rs10492401chr1333489671BAG395310.16trans
rs17103412chr1466725774BAG395310.1trans
rs7215675chr1710905819BAG395310.16trans
rs16944595chr1711242834BAG395310trans
rs16944600chr1711245098BAG395310.06trans
rs16944601chr1711245219BAG395310.03trans
rs2073206chr20948279BAG395310.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
QRICH10.950.97
KIAA19670.950.96
WDR50.950.95
DHX80.950.96
SART30.950.95
KIAA01740.950.94
EFTUD20.940.95
EDC30.940.95
USP100.940.94
C20orf110.940.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.84-0.90
MT-CO2-0.83-0.91
AF347015.27-0.80-0.88
AF347015.33-0.80-0.86
AF347015.8-0.80-0.90
MT-CYB-0.80-0.87
FXYD1-0.78-0.87
AF347015.21-0.77-0.92
AF347015.15-0.77-0.87
HIGD1B-0.77-0.86

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP 3123All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 13680All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 8748All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 11071All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
GOLDRATH IMMUNE MEMORY 6542All SZGR 2.0 genes in this pathway
HADDAD T LYMPHOCYTE AND NK PROGENITOR UP 7856All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
HU GENOTOXIC DAMAGE 24HR 3522All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 2HR 5136All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 1 3324All SZGR 2.0 genes in this pathway
TRACEY RESISTANCE TO IFNA2 DN 3223All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 13899All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 14895All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 14675All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway