Gene Page: ENTPD6

Summary ?
GeneID955
SymbolENTPD6
SynonymsCD39L2|IL-6SAG|IL6ST2|NTPDase-6|dJ738P15.3
Descriptionectonucleoside triphosphate diphosphohydrolase 6 (putative)
ReferenceMIM:603160|HGNC:HGNC:3368|Ensembl:ENSG00000197586|HPRD:16013|Vega:OTTHUMG00000032116
Gene typeprotein-coding
Map location20p11.21
Pascal p-value0.051
Sherlock p-value0.994
DMG2 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg009263182025177340ENTPD64.662E-40.4740.046DMG:Wockner_2014
cg049748992025177027ENTPD64.32E-8-0.0131.19E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SFRP40.820.73
AC015908.20.760.59
STK330.750.70
WDR490.740.59
AK70.720.54
SULT1C40.710.65
CCDC1350.710.36
DNAH90.710.57
ANXA10.710.55
NEK50.710.46
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IER5L-0.38-0.49
MPPED1-0.35-0.52
MEF2C-0.35-0.48
KLHL1-0.34-0.45
SATB2-0.33-0.50
GPR22-0.33-0.50
SLC26A4-0.32-0.47
GPR21-0.32-0.45
SLA-0.32-0.40
TIAM2-0.32-0.46

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PURINE METABOLISM 15996All SZGR 2.0 genes in this pathway
KEGG PYRIMIDINE METABOLISM 9853All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER UP 9657All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS DN 6639All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 4 4832All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE UP 4334All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
KYNG RESPONSE TO H2O2 VIA ERCC6 UP 4030All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 DN 4830All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP C 9260All SZGR 2.0 genes in this pathway