SZGR2

Summary ?

GeneID	958
Symbol	CD40
Synonyms	Bp50\|CDW40\|TNFRSF5\|p50
Description	CD40 molecule
Reference	MIM:109535\|HGNC:HGNC:11919\|Ensembl:ENSG00000101017\|HPRD:00178\|Vega:OTTHUMG00000033053
Gene type	protein-coding
Map location	20q12-q13.2
Pascal p-value	0.003
Fetal beta	-0.62

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
LAPTM5	0.86	0.88
C1QC	0.83	0.84
ADORA3	0.82	0.81
CTSS	0.80	0.80
C3	0.80	0.79
C3AR1	0.80	0.84
FCGR3A	0.80	0.77
ITGB2	0.78	0.79
NCKAP1L	0.78	0.77
TBXAS1	0.78	0.81

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AC010300.1	-0.31	-0.38
AC005921.3	-0.31	-0.44
ZNF814	-0.30	-0.37
RP9P	-0.29	-0.41
ANP32C	-0.29	-0.29
ANKRD36B	-0.28	-0.38
UPF3A	-0.28	-0.32
SCUBE1	-0.28	-0.20
SH2D2A	-0.28	-0.30
ANKRD36	-0.27	-0.35

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	Affinity Capture-MS	BioGRID	17353931
CD40LG	CD154 \| CD40L \| HIGM1 \| IGM \| IMD3 \| T-BAM \| TNFSF5 \| TRAP \| gp39 \| hCD40L	CD40 ligand	-	HPRD	7516405 \|7543281 \|10647992
DDX3X	DBX \| DDX14 \| DDX3 \| HLP2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	Affinity Capture-MS	BioGRID	17353931
FBL	FIB \| FLRN \| RNU3IP1	fibrillarin	Affinity Capture-MS	BioGRID	17353931
MS4A1	B1 \| Bp35 \| CD20 \| LEU-16 \| MGC3969 \| MS4A2 \| S7	membrane-spanning 4-domains, subfamily A, member 1	-	HPRD,BioGRID	9933087
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Reconstituted Complex	BioGRID	10847592
NSMAF	FAN	neutral sphingomyelinase (N-SMase) activation associated factor	-	HPRD	10601289
POLR2H	RPABC3 \| RPB17 \| RPB8 \| hsRPB8	polymerase (RNA) II (DNA directed) polypeptide H	Affinity Capture-MS	BioGRID	17353931
RFC5	MGC1155 \| RFC36	replication factor C (activator 1) 5, 36.5kDa	Affinity Capture-MS	BioGRID	17353931
RIPK2	CARD3 \| CARDIAK \| CCK \| GIG30 \| RICK \| RIP2	receptor-interacting serine-threonine kinase 2	-	HPRD,BioGRID	9642260
RNF219	C13orf7 \| DKFZp686A01276 \| DKFZp686N15250 \| DKFZp686O03173 \| FLJ13449 \| FLJ25774	ring finger protein 219	Affinity Capture-MS	BioGRID	17353931
SGK1	SGK	serum/glucocorticoid regulated kinase 1	Affinity Capture-MS	BioGRID	17353931
SLC30A7	DKFZp686M0368 \| ZNT7 \| ZnT-7 \| ZnTL2	solute carrier family 30 (zinc transporter), member 7	Affinity Capture-MS	BioGRID	17353931
SLC39A7	D6S115E \| D6S2244E \| H2-KE4 \| HKE4 \| KE4 \| RING5 \| ZIP7	solute carrier family 39 (zinc transporter), member 7	Affinity Capture-MS	BioGRID	17353931
SUMO1	DAP-1 \| GMP1 \| OFC10 \| PIC1 \| SENP2 \| SMT3 \| SMT3C \| SMT3H3 \| SUMO-1 \| UBL1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	Two-hybrid	BioGRID	8906799
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD	7527023 \|10411888
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	-	HPRD,BioGRID	10411888
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	CD40 interacts with TRAF2.	BIND	10352240
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD	7527023 \|7530216 \|7533327 \|10984535
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	Affinity Capture-Western Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	7527023 \|9384571 \|9990007 \|10984535
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	CD40 interacts with TRAF3.	BIND	10352240
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD	7527023 \|7533327 \|10984535
TRAF3IP2	ACT1 \| C6orf2 \| C6orf4 \| C6orf5 \| C6orf6 \| CIKS \| DKFZp586G0522 \| MGC3581	TRAF3 interacting protein 2	-	HPRD,BioGRID	12089335
TRAF5	MGC:39780 \| RNF84	TNF receptor-associated factor 5	-	HPRD,BioGRID	8790348 \|9990007
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	Reconstituted Complex	BioGRID	9384571 \|9990007
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD	10075662 \|10411888
TTRAP	AD022 \| EAP2 \| MGC111021 \| MGC9099 \| dJ30M3.3	TRAF and TNF receptor associated protein	-	HPRD,BioGRID	10764746
TXN	DKFZp686B1993 \| MGC61975 \| TRX \| TRX1	thioredoxin	Affinity Capture-MS	BioGRID	17353931
TXNDC4	ERP44 \| KIAA0573	thioredoxin domain containing 4 (endoplasmic reticulum)	Affinity Capture-MS	BioGRID	17353931
UGCGL1	FLJ23671 \| FLJ23796 \| HUGT1	UDP-glucose ceramide glucosyltransferase-like 1	Affinity Capture-MS	BioGRID	17353931
USP15	KIAA0529 \| MGC131982 \| MGC149838 \| MGC74854 \| UNPH4	ubiquitin specific peptidase 15	Affinity Capture-MS	BioGRID	17353931
XRCC5	FLJ39089 \| KARP-1 \| KARP1 \| KU80 \| KUB2 \| Ku86 \| NFIV	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	-	HPRD,BioGRID	10514012
XRCC6	CTC75 \| CTCBF \| G22P1 \| KU70 \| ML8 \| TLAA	X-ray repair complementing defective repair in Chinese hamster cells 6	-	HPRD,BioGRID	10514012

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	267	161	All SZGR 2.0 genes in this pathway
KEGG CELL ADHESION MOLECULES CAMS	134	93	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION	48	36	All SZGR 2.0 genes in this pathway
KEGG ASTHMA	30	25	All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE	53	49	All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS	140	100	All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION	38	34	All SZGR 2.0 genes in this pathway
KEGG PRIMARY IMMUNODEFICIENCY	35	28	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA BLYMPHOCYTE PATHWAY	11	8	All SZGR 2.0 genes in this pathway
BIOCARTA CD40 PATHWAY	15	13	All SZGR 2.0 genes in this pathway
BIOCARTA DC PATHWAY	22	20	All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY	19	14	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
PID CD40 PATHWAY	31	26	All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	70	37	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA DN	15	10	All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN	95	57	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP	238	135	All SZGR 2.0 genes in this pathway
RAMJAUN APOPTOSIS BY TGFB1 VIA SMAD4 UP	7	6	All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION	45	34	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY	66	48	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP	57	41	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5	94	59	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN	637	377	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN	411	249	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 9	19	13	All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE DN	58	39	All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE UP	53	35	All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE UP	90	62	All SZGR 2.0 genes in this pathway
MORI PLASMA CELL DN	33	20	All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA DN	58	42	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP	203	130	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP	101	76	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP	89	59	All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN	135	88	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESISTANCE	20	14	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP	476	285	All SZGR 2.0 genes in this pathway
GALI TP53 TARGETS APOPTOTIC UP	8	7	All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP	259	185	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP	77	56	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A	67	52	All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP	70	49	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN	442	275	All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP	288	168	All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K27ME3	74	46	All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3	206	108	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR DN	37	20	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP	199	143	All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA	208	107	All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE	78	48	All SZGR 2.0 genes in this pathway

Gene Page: CD40