Gene Page: CD63

Summary ?
GeneID967
SymbolCD63
SynonymsLAMP-3|ME491|MLA1|OMA81H|TSPAN30
DescriptionCD63 molecule
ReferenceMIM:155740|HGNC:HGNC:1692|Ensembl:ENSG00000135404|HPRD:01121|Vega:OTTHUMG00000170454
Gene typeprotein-coding
Map location12q13.2
Pascal p-value0.636
Sherlock p-value0.288
Fetal beta-0.745
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg216010591256122983CD633.09E-4-0.1860.04DMG:Wockner_2014
cg199872881256122958CD634.436E-4-0.6070.045DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs9313483chr5169448229CD639670.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HLA-DPA10.930.94
HLA-DRA0.880.90
HLA-DRB10.840.88
HLA-DQA10.800.85
HLA-DRB50.790.83
HLA-DPB10.790.86
HLA-DMB0.780.81
EVI2B0.780.85
HLA-DMA0.770.78
MAP70.750.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA1949-0.54-0.66
TUBB2B-0.54-0.72
NKIRAS2-0.53-0.63
ZNF311-0.52-0.65
ZNF821-0.52-0.63
SH3BP2-0.52-0.70
ZNF300-0.52-0.64
AC004017.1-0.52-0.64
ZNF551-0.51-0.64
TIGD1-0.51-0.63

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AP4M1MU-4 | MU-ARP2adaptor-related protein complex 4, mu 1 subunit-HPRD,BioGRID10436028 
CD81S5.7 | TAPA1 | TSPAN28CD81 molecule-HPRD12036870 
CD81S5.7 | TAPA1 | TSPAN28CD81 moleculein vivoBioGRID9006891 
CD824F9 | C33 | GR15 | IA4 | KAI1 | R2 | SAR2 | ST6 | TSPAN27CD82 molecule-HPRD,BioGRID9759843 
CD95H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29CD9 molecule-HPRD,BioGRID8630057 |11204565 
|12175627 
HLA-DMBD6S221E | RING7major histocompatibility complex, class II, DM beta-HPRD,BioGRID9759843 
HLA-DOBDOBmajor histocompatibility complex, class II, DO betaAffinity Capture-WesternBioGRID9759843 
HLA-DRAHLA-DRA1major histocompatibility complex, class II, DR alpha-HPRD,BioGRID9759843 
ITGA6CD49f | DKFZp686J01244 | FLJ18737 | ITGA6B | VLA-6integrin, alpha 6-HPRD,BioGRID7629079 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)Affinity Capture-WesternBioGRID12175627 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID12036870 
PTGFRNCD315 | CD9P-1 | EWI-F | FLJ11001 | FPRP | KIAA1436 | SMAP-6prostaglandin F2 receptor negative regulator-HPRD,BioGRID11278880 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)Two-hybridBioGRID9271374 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG LYSOSOME 12183All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 8956All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205140All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP 5844All SZGR 2.0 genes in this pathway
BORLAK LIVER CANCER EGF UP 5741All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 8151All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP 6140All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 6440All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 UP 5130All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP 5634All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE UP 6042All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA UP 6040All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP 6235All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN 4430All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 8152All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249170All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 5233All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 13588All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
LEIN ASTROCYTE MARKERS 4235All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G 17196All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 8066All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
ALONSO METASTASIS EMT UP 3624All SZGR 2.0 genes in this pathway
ALONSO METASTASIS NEURAL UP 1813All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238145All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP 1811All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 3623All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 6638All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN 11674All SZGR 2.0 genes in this pathway