Gene Page: KIAA0391
Summary ?
| GeneID | 9692 |
| Symbol | KIAA0391 |
| Synonyms | MRPP3|PRORP |
| Description | KIAA0391 |
| Reference | MIM:609947|HGNC:HGNC:19958|Ensembl:ENSG00000100890|HPRD:18711|Vega:OTTHUMG00000170997 |
| Gene type | protein-coding |
| Map location | 14q13.2 |
| Pascal p-value | 1.514E-4 |
| Fetal beta | 0.332 |
| DMG | 1 (# studies) |
| eGene | Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg04966789 | 14 | 35591779 | KIAA0391 | 5.34E-8 | -0.007 | 1.39E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| YTHDF2 | 0.97 | 0.96 |
| EDC3 | 0.95 | 0.94 |
| POLR1B | 0.95 | 0.95 |
| RSPRY1 | 0.95 | 0.95 |
| RBM12 | 0.95 | 0.95 |
| KDM4A | 0.94 | 0.94 |
| ZNF304 | 0.94 | 0.93 |
| C2orf44 | 0.94 | 0.93 |
| TRAFD1 | 0.94 | 0.91 |
| TRIM27 | 0.94 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.72 | -0.91 |
| AF347015.31 | -0.72 | -0.89 |
| HLA-F | -0.72 | -0.78 |
| C5orf53 | -0.72 | -0.77 |
| AF347015.27 | -0.72 | -0.88 |
| AF347015.33 | -0.71 | -0.89 |
| AIFM3 | -0.71 | -0.77 |
| S100B | -0.70 | -0.83 |
| FXYD1 | -0.70 | -0.87 |
| MT-CYB | -0.70 | -0.89 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| INAMURA LUNG CANCER SCC SUBTYPES UP | 14 | 9 | All SZGR 2.0 genes in this pathway |
| LOCKWOOD AMPLIFIED IN LUNG CANCER | 214 | 139 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 12HR UP | 111 | 68 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |