SZGR2

Summary ?

GeneID	9788
Symbol	MTSS1
Synonyms	MIM\|MIMA\|MIMB
Description	metastasis suppressor 1
Reference	MIM:608486\|HGNC:HGNC:20443\|Ensembl:ENSG00000170873\|HPRD:12243\|Vega:OTTHUMG00000048189
Gene type	protein-coding
Map location	8p22
Pascal p-value	0.069
Sherlock p-value	0.31
Fetal beta	1.912
eGene	Myers' cis & trans Meta

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs12463686	chr2	241066951	MTSS1	9788		0.07		trans
rs7567372	chr2	241069830	MTSS1	9788		0.1		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005102	receptor binding	IPI	Neurotransmitter (GO term level: 4)	12570871
GO:0003785	actin monomer binding	IDA		12570871
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0046847	filopodium formation	IEA	axon (GO term level: 10)	-
GO:0007399	nervous system development	IEA	neurite (GO term level: 5)	-
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS		12570871
GO:0007155	cell adhesion	NAS		12570871
GO:0007165	signal transduction	IEA		-
GO:0006928	cell motion	NAS		12570871
GO:0030036	actin cytoskeleton organization	TAS		12082544
GO:0045786	negative regulation of cell cycle	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001726	ruffle	NAS		12570871
GO:0005737	cytoplasm	TAS		12570871
GO:0015629	actin cytoskeleton	IDA		12570871
GO:0030139	endocytic vesicle	TAS		12570871

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID HEDGEHOG GLI PATHWAY	48	35	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN	169	118	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL DN	60	39	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK DN	11	5	All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP	157	91	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP	55	34	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN	781	465	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION DN	19	17	All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP	207	128	All SZGR 2.0 genes in this pathway
EBAUER MYOGENIC TARGETS OF PAX3 FOXO1 FUSION	50	26	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
GEORGES CELL CYCLE MIR192 TARGETS	62	46	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON	157	87	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN	464	276	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP	207	145	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS UP	48	34	All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP	412	249	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL	293	160	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP	180	125	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP	578	341	All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS UP	46	30	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS UP	20	14	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN	80	66	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
CLIMENT BREAST CANCER COPY NUMBER UP	23	20	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP	185	112	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP	91	63	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT	567	365	All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP	194	133	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS DN	7	7	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP	489	314	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	66	72	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-103/107	814	820	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	814	820	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-135	705	712	1A,m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	705	712	1A,m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-141/200a	721	727	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	721	727	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-15/16/195/424/497	815	821	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-182	1928	1935	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-182	1928	1935	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-23	1950	1956	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1950	1956	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24*	97	104	1A,m8	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-28	1674	1680	m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-323	1950	1956	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-342	1531	1537	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-370	996	1002	m8	hsa-miR-370^brain	GCCUGCUGGGGUGGAACCUGG
miR-381	2114	2121	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-495	725	731	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-542-3p	2007	2013	1A	hsa-miR-542-3p	UGUGACAGAUUGAUAACUGAAA
miR-96	261	268	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	261	268	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MTSS1