SZGR2

Summary ?

GeneID	9802
Symbol	DAZAP2
Synonyms	PRTB
Description	DAZ associated protein 2
Reference	MIM:607431\|HGNC:HGNC:2684\|Ensembl:ENSG00000183283\|HPRD:08463\|Vega:OTTHUMG00000169649
Gene type	protein-coding
Map location	12q12
Pascal p-value	0.093
Sherlock p-value	0.614
Fetal beta	-0.791
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.01

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg17322163	12	51632344	DAZAP2	1.476E-4	-0.324	0.032	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CCNH	0.82	0.81
ATP5C1	0.81	0.81
PSMA6	0.81	0.80
C3orf14	0.81	0.84
NFU1	0.80	0.81
CHMP5	0.80	0.81
MRPL1	0.79	0.81
PSMC6	0.79	0.83
TXNDC9	0.79	0.82
PARL	0.79	0.78

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
DOCK6	-0.58	-0.63
ENG	-0.56	-0.58
NOS3	-0.52	-0.56
FAM38A	-0.51	-0.57
LIMS2	-0.51	-0.56
GATA2	-0.50	-0.54
MTSS1L	-0.50	-0.51
SEMA3G	-0.49	-0.52
AF347015.18	-0.48	-0.46
LAMB2	-0.48	-0.53

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		16713569

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AATF	CHE-1 \| CHE1 \| DED	apoptosis antagonizing transcription factor	Two-hybrid	BioGRID	16189514
BAG3	BAG-3 \| BIS \| CAIR-1 \| MGC104307	BCL2-associated athanogene 3	Two-hybrid	BioGRID	16189514
BATF2	MGC20410	basic leucine zipper transcription factor, ATF-like 2	Two-hybrid	BioGRID	16189514
C1orf94	MGC15882	chromosome 1 open reading frame 94	Two-hybrid	BioGRID	16189514
CALCOCO2	MGC17318 \| NDP52	calcium binding and coiled-coil domain 2	Two-hybrid	BioGRID	16189514
CCDC120	JM11	coiled-coil domain containing 120	Two-hybrid	BioGRID	16189514
DAZ1	DAZ \| SPGY	deleted in azoospermia 1	-	HPRD,BioGRID	10857750
DAZAP2	KIAA0058 \| MGC14319 \| MGC766 \| PRTB	DAZ associated protein 2	Two-hybrid	BioGRID	16189514
DAZL	DAZH \| DAZL1 \| DAZLA \| MGC26406 \| SPGYLA	deleted in azoospermia-like	-	HPRD,BioGRID	10857750
DCUN1D1	DCUN1L1 \| RP42 \| SCCRO \| SCRO \| Tes3	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	Two-hybrid	BioGRID	16189514
FAM46C	FLJ20202	family with sequence similarity 46, member C	Two-hybrid	BioGRID	16189514
FLJ20433	FLJ30442 \| MGC131904 \| MGC74981	hypothetical protein FLJ20433	Two-hybrid	BioGRID	16189514
GPSM1	AGS3 \| DKFZp727I051	G-protein signaling modulator 1 (AGS3-like, C. elegans)	Two-hybrid	BioGRID	16189514
HGS	HRS \| ZFYVE8	hepatocyte growth factor-regulated tyrosine kinase substrate	Two-hybrid	BioGRID	16189514
LMO2	RBTN2 \| RBTNL1 \| RHOM2 \| TTG2	LIM domain only 2 (rhombotin-like 1)	Two-hybrid	BioGRID	16189514
LOC83459	MGC88636	hypothetical protein LOC83459	Two-hybrid	BioGRID	16189514
NDUFA5	B13 \| CI-13KD-B \| DKFZp781K1356 \| FLJ12147 \| NUFM \| UQOR13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa	Two-hybrid	BioGRID	16189514
NEDD4	KIAA0093 \| MGC176705 \| NEDD4-1 \| RPF1	neural precursor cell expressed, developmentally down-regulated 4	-	HPRD	11342538
NOC4L	MGC3162 \| NOC4	nucleolar complex associated 4 homolog (S. cerevisiae)	Two-hybrid	BioGRID	16189514
PLSCR1	MMTRA1B	phospholipid scramblase 1	Two-hybrid	BioGRID	16189514
POLI	RAD30B \| RAD3OB	polymerase (DNA directed) iota	Two-hybrid	BioGRID	16189514
RBM9	FOX2 \| Fox-2 \| HNRBP2 \| HRNBP2 \| RTA \| dJ106I20.3 \| fxh	RNA binding motif protein 9	Two-hybrid	BioGRID	16189514
RBPMS	HERMES	RNA binding protein with multiple splicing	Two-hybrid	BioGRID	16189514
RHOXF2	PEPP-2 \| PEPP2 \| THG1	Rhox homeobox family, member 2	Two-hybrid	BioGRID	16189514
RPS27A	CEP80 \| HUBCEP80 \| UBA80 \| UBCEP1 \| UBCEP80	ribosomal protein S27a	Two-hybrid	BioGRID	16189514
SEPT2	DIFF6 \| KIAA0158 \| NEDD5 \| Pnutl3 \| hNedd5	septin 2	Two-hybrid	BioGRID	16189514
STAM2	DKFZp564C047 \| Hbp \| STAM2A \| STAM2B	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Two-hybrid	BioGRID	16189514
TOLLIP	FLJ33531 \| IL-1RAcPIP	toll interacting protein	Two-hybrid	BioGRID	16189514
UBAC1	GBDR1 \| RP11-432J22.3 \| UBADC1	UBA domain containing 1	Two-hybrid	BioGRID	16189514
UBB	FLJ25987 \| MGC8385	ubiquitin B	Two-hybrid	BioGRID	16189514
UBC	HMG20	ubiquitin C	Two-hybrid	BioGRID	16189514
WWP1	AIP5 \| DKFZp434D2111 \| Tiul1 \| hSDRP1	WW domain containing E3 ubiquitin protein ligase 1	Two-hybrid	BioGRID	16189514
ZFAND2B	-	zinc finger, AN1-type domain 2B	Two-hybrid	BioGRID	16189514
ZNF581	FLJ22550 \| HSPC189	zinc finger protein 581	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN	391	222	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP	194	112	All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE	217	143	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0	107	72	All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN	106	68	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3	720	440	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN	238	145	All SZGR 2.0 genes in this pathway
ELLWOOD MYC TARGETS DN	40	27	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
IVANOVSKA MIR106B TARGETS	90	56	All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS	206	127	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP	745	475	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-125/351	1075	1081	1A	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1075	1081	1A	hsa-miR-125a^brain	UCCCUGAGACCCUUUAACCUGUG
miR-128	1233	1239	m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1233	1239	m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-132/212	1195	1202	1A,m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	1195	1202	1A,m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-17-5p/20/93.mr/106/519.d	143	149	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-181	231	237	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	367	374	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-452	808	814	m8	hsa-miR-452	UGUUUGCAGAGGAAACUGAGAC
miR-496	168	174	m8	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-93.hd/291-3p/294/295/302/372/373/520	1242	1248	1A	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
				hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU
miR-96	368	374	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: DAZAP2