Gene Page: PLEKHM1
Summary ?
| GeneID | 9842 |
| Symbol | PLEKHM1 |
| Synonyms | AP162|B2|OPTB6 |
| Description | pleckstrin homology and RUN domain containing M1 |
| Reference | MIM:611466|HGNC:HGNC:29017|Ensembl:ENSG00000225190|HPRD:11439|Vega:OTTHUMG00000179074 |
| Gene type | protein-coding |
| Map location | 17q21.31 |
| Pascal p-value | 0.022 |
| Sherlock p-value | 0.134 |
| eGene | Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FBXL6 | 0.90 | 0.82 |
| WDR85 | 0.89 | 0.89 |
| ACD | 0.89 | 0.91 |
| HEXDC | 0.88 | 0.87 |
| MFSD10 | 0.87 | 0.91 |
| PLSCR3 | 0.87 | 0.83 |
| UCKL1 | 0.87 | 0.82 |
| CENPT | 0.87 | 0.86 |
| QTRT1 | 0.86 | 0.86 |
| ANKS3 | 0.86 | 0.84 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.63 | -0.72 |
| AF347015.31 | -0.63 | -0.73 |
| MT-CO2 | -0.62 | -0.72 |
| AF347015.33 | -0.62 | -0.71 |
| AF347015.8 | -0.61 | -0.73 |
| MT-CYB | -0.60 | -0.71 |
| AF347015.15 | -0.58 | -0.70 |
| S100B | -0.56 | -0.66 |
| AF347015.2 | -0.56 | -0.70 |
| AF347015.21 | -0.56 | -0.75 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN | 382 | 224 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
| CADWELL ATG16L1 TARGETS UP | 93 | 56 | All SZGR 2.0 genes in this pathway |
| SENGUPTA EBNA1 ANTICORRELATED | 173 | 85 | All SZGR 2.0 genes in this pathway |
| GREGORY SYNTHETIC LETHAL WITH IMATINIB | 145 | 83 | All SZGR 2.0 genes in this pathway |
| LINSLEY MIR16 TARGETS | 206 | 127 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |