Summary ?
GeneID9856
SymbolKIAA0319
SynonymsDYLX2|DYX2|NMIG
DescriptionKIAA0319
ReferenceMIM:609269|HGNC:HGNC:21580|Ensembl:ENSG00000137261|HPRD:18713|Vega:OTTHUMG00000014358
Gene typeprotein-coding
Map location6p22.3
Pascal p-value0.003
Sherlock p-value0.212
Fetal beta-0.002
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg12659381624646254KIAA03194.55E-9-0.0192.67E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LCORL0.910.89
ZNF33B0.900.92
COMMD20.900.87
CSGALNACT20.890.92
DDX210.890.92
STT3B0.880.92
EIF4B0.880.88
ZNF33A0.880.93
UBXN2B0.880.94
C14orf370.870.90
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SERPINB6-0.66-0.76
HSD17B14-0.64-0.81
HEPN1-0.62-0.74
TSC22D4-0.62-0.78
FXYD1-0.62-0.85
AIFM3-0.62-0.75
RAMP1-0.61-0.78
AC018755.7-0.61-0.70
AF347015.31-0.61-0.83
ROM1-0.60-0.78

Section III. Gene Ontology annotation

Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176104All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP 163100All SZGR 2.0 genes in this pathway