SZGR2

Summary ?

GeneID	9863
Symbol	MAGI2
Synonyms	ACVRIP1\|AIP-1\|AIP1\|ARIP1\|MAGI-2\|SSCAM
Description	membrane associated guanylate kinase, WW and PDZ domain containing 2
Reference	MIM:606382\|HGNC:HGNC:18957\|Ensembl:ENSG00000187391\|HPRD:16212\|Vega:OTTHUMG00000130697
Gene type	protein-coding
Map location	7q21
Fetal beta	0.238
DMG	2 (# studies)
Support	CompositeSet Darnell FMRP targets Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	3
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	3
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	3	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg13051700	7	79050007	MAGI2	8.29E-5	-0.549	0.026	DMG:Wockner_2014
cg06809544	7	79081666	MAGI2	1.19E-8	-0.013	4.92E-6	DMG:Jaffe_2016
cg05270344	7	79083635	MAGI2	1E-7	-0.007	2.21E-5	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
POLR2C	0.90	0.88
CIAO1	0.88	0.87
PRPF19	0.85	0.85
TMED4	0.85	0.82
KLHL12	0.84	0.83
TOX4	0.84	0.82
C1orf109	0.83	0.81
SURF4	0.83	0.82
PI4KB	0.83	0.81
CNBP	0.83	0.82

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.8	-0.65	-0.63
AF347015.21	-0.65	-0.64
MT-CO2	-0.65	-0.61
AF347015.26	-0.63	-0.61
MT-CYB	-0.63	-0.61
AF347015.31	-0.63	-0.60
AF347015.18	-0.62	-0.70
AF347015.2	-0.62	-0.56
AF347015.15	-0.62	-0.60
AF347015.33	-0.61	-0.58

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		9647693
GO:0019902	phosphatase binding	IPI		10760291
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0019717	synaptosome	IEA	Synap, Brain (GO term level: 7)	-
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0005886	plasma membrane	IEA		-
GO:0030054	cell junction	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME NEPHRIN INTERACTIONS	20	15	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN	367	220	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN	98	59	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP	344	180	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP	182	119	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN	86	62	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
MOLENAAR TARGETS OF CCND1 AND CDK4 UP	67	48	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP	172	109	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN	209	137	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	2025	2031	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	1858	1865	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-101	1858	1865	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	402	408	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-134	2109	2115	1A	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-141/200a	2046	2052	1A	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2046	2052	1A	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-144	2191	2197	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	390	397	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-19	1936	1943	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1936	1943	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-205	325	332	1A,m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-218	1711	1718	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-27	2054	2060	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	2054	2060	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-30-5p	2187	2193	m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-320	286	292	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-339	503	509	m8	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-485-3p	2194	2200	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-485-5p	1641	1647	1A	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-539	1030	1037	1A,m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAGI2