Gene Page: MAGI2

Summary
GeneID  9863
Symbol  MAGI2
Synonyms  ACVRIP1|AIP1|ARIP1|MAGI-2|SSCAM
Description  membrane associated guanylate kinase, WW and PDZ domain containing 2
See related  HGNC:18957|MIM:606382|Ensembl:ENSG00000187391|HPRD:16212|
Locus tag  -
Gene type  protein-coding
Map location  7q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
POLR2C0.900.88
CIAO10.880.87
PRPF190.850.85
TMED40.850.82
KLHL120.840.83
TOX40.840.82
C1orf1090.830.81
SURF40.830.82
PI4KB0.830.81
CNBP0.830.82
Top 10 negatively co-expressed genes
AF347015.8-0.65-0.63
AF347015.21-0.65-0.64
MT-CO2-0.65-0.61
AF347015.26-0.63-0.61
MT-CYB-0.63-0.61
AF347015.31-0.63-0.60
AF347015.18-0.62-0.70
AF347015.2-0.62-0.56
AF347015.15-0.62-0.60
AF347015.33-0.61-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI9647693 
GO:0019902phosphatase bindingIPI10760291 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR2AACTRII | ACVR2activin A receptor, type IIA-HPRD10681527 
ADRB1ADRB1R | B1AR | BETA1AR | RHRadrenergic, beta-1-, receptor-HPRD11526121 
ATN1B37 | D12S755E | DRPLA | NODatrophin 1Atrophin-1 interacts with AIP1.BIND9647693 
-HPRD9647693 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD11826105 
DSCAML1KIAA1132Down syndrome cell adhesion molecule like 1-HPRD12421765 
MAGI2ACVRIP1 | AIP1 | ARIP1 | MAGI-2 | SSCAMmembrane associated guanylate kinase, WW and PDZ domain containing 2-HPRD10681527 
PTEN10q23del | BZS | MGC11227 | MHAM | MMAC1 | PTEN1 | TEP1phosphatase and tensin homolog-HPRD10760291 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD10681527 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_NEPHRIN_INTERACTIONS 2015All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_DN 367220All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN 9859All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP 182119All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_UP 6748All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
CHANG_CORE_SERUM_RESPONSE_DN 209137All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206202520311Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-101185818651A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124.14024081Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-134210921151Ahsa-miR-134brainUGUGACUGGUUGACCAGAGGG
miR-141/200a204620521Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-144219121971Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1453903971A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-19193619431A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-2053253321A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-218171117181A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-27205420601Ahsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-30-5p21872193m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3202862921Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-339503509m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-485-3p21942200m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-485-5p164116471Ahsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-539103010371A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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