Summary ?
GeneID9866
SymbolTRIM66
SynonymsC11orf29|TIF1D|TIF1DELTA
Descriptiontripartite motif containing 66
ReferenceMIM:612000|HGNC:HGNC:29005|Ensembl:ENSG00000166436|Vega:OTTHUMG00000150481
Gene typeprotein-coding
Map location11p15.4
Pascal p-value0.785
Sherlock p-value0.318
Fetal beta-1.293
DMG1 (# studies)
eGeneCaudate basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13143389118680333TRIM665.832E-40.3150.049DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MARCH50.870.89
BFAR0.870.87
ZNF5690.860.86
SUZ120.860.87
THADA0.860.85
COPB10.860.90
ELP20.860.86
METAP20.860.86
TMEFF10.860.87
ZNF4200.860.87
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.69-0.78
AF347015.8-0.67-0.78
AF347015.31-0.67-0.76
AF347015.27-0.67-0.76
AF347015.33-0.67-0.76
MT-CYB-0.66-0.76
AF347015.21-0.64-0.75
AF347015.15-0.64-0.75
AF347015.2-0.64-0.76
FXYD1-0.63-0.75

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GAZIN EPIGENETIC SILENCING BY KRAS 2616All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway