Gene Page: TRIM66
Summary ?
| GeneID | 9866 |
| Symbol | TRIM66 |
| Synonyms | C11orf29|TIF1D|TIF1DELTA |
| Description | tripartite motif containing 66 |
| Reference | MIM:612000|HGNC:HGNC:29005|Ensembl:ENSG00000166436|Vega:OTTHUMG00000150481 |
| Gene type | protein-coding |
| Map location | 11p15.4 |
| Pascal p-value | 0.785 |
| Sherlock p-value | 0.318 |
| Fetal beta | -1.293 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg13143389 | 11 | 8680333 | TRIM66 | 5.832E-4 | 0.315 | 0.049 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MARCH5 | 0.87 | 0.89 |
| BFAR | 0.87 | 0.87 |
| ZNF569 | 0.86 | 0.86 |
| SUZ12 | 0.86 | 0.87 |
| THADA | 0.86 | 0.85 |
| COPB1 | 0.86 | 0.90 |
| ELP2 | 0.86 | 0.86 |
| METAP2 | 0.86 | 0.86 |
| TMEFF1 | 0.86 | 0.87 |
| ZNF420 | 0.86 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.69 | -0.78 |
| AF347015.8 | -0.67 | -0.78 |
| AF347015.31 | -0.67 | -0.76 |
| AF347015.27 | -0.67 | -0.76 |
| AF347015.33 | -0.67 | -0.76 |
| MT-CYB | -0.66 | -0.76 |
| AF347015.21 | -0.64 | -0.75 |
| AF347015.15 | -0.64 | -0.75 |
| AF347015.2 | -0.64 | -0.76 |
| FXYD1 | -0.63 | -0.75 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GAZIN EPIGENETIC SILENCING BY KRAS | 26 | 16 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |
| PEDRIOLI MIR31 TARGETS DN | 418 | 245 | All SZGR 2.0 genes in this pathway |