Gene Page: KIAA0196
Summary ?
| GeneID | 9897 |
| Symbol | KIAA0196 |
| Synonyms | RTSC|RTSC1|SPG8 |
| Description | KIAA0196 |
| Reference | MIM:610657|HGNC:HGNC:28984|Ensembl:ENSG00000164961|HPRD:13786|Vega:OTTHUMG00000164991 |
| Gene type | protein-coding |
| Map location | 8q24.13 |
| Pascal p-value | 0.075 |
| Sherlock p-value | 0.002 |
| Fetal beta | -0.219 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ADNP | 0.96 | 0.97 |
| TCEB3 | 0.95 | 0.95 |
| SUV420H1 | 0.95 | 0.96 |
| RSPRY1 | 0.95 | 0.95 |
| ZNF518B | 0.95 | 0.95 |
| RBM12 | 0.95 | 0.95 |
| ZNF304 | 0.95 | 0.94 |
| KDM4A | 0.95 | 0.95 |
| CNOT6 | 0.94 | 0.95 |
| MEX3C | 0.94 | 0.96 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AIFM3 | -0.75 | -0.80 |
| AF347015.31 | -0.74 | -0.89 |
| FXYD1 | -0.73 | -0.89 |
| MT-CO2 | -0.73 | -0.90 |
| C5orf53 | -0.73 | -0.77 |
| HLA-F | -0.73 | -0.77 |
| TSC22D4 | -0.72 | -0.81 |
| AF347015.27 | -0.72 | -0.86 |
| S100B | -0.72 | -0.83 |
| IFI27 | -0.72 | -0.87 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON | 157 | 87 | All SZGR 2.0 genes in this pathway |
| DING LUNG CANCER EXPRESSION BY COPY NUMBER | 100 | 62 | All SZGR 2.0 genes in this pathway |
| HOEGERKORP CD44 TARGETS TEMPORAL DN | 25 | 16 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 | 482 | 296 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP | 863 | 514 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G3 UP | 188 | 121 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | 193 | 112 | All SZGR 2.0 genes in this pathway |