Gene Page: SLC35E2
Summary ?
| GeneID | 9906 |
| Symbol | SLC35E2 |
| Synonyms | - |
| Description | solute carrier family 35 member E2 |
| Reference | HGNC:HGNC:20863|Ensembl:ENSG00000215790|HPRD:15374|Vega:OTTHUMG00000000823 |
| Gene type | protein-coding |
| Map location | 1p36.33 |
| Pascal p-value | 0.511 |
| Sherlock p-value | 0.567 |
| Fetal beta | 0.498 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg27391816 | 1 | 1672644 | SLC35E2 | 4.265E-4 | 0.621 | 0.045 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs332104 | chr2 | 119446029 | SLC35E2 | 9906 | 0.17 | trans | ||
| rs17029291 | chr3 | 32402138 | SLC35E2 | 9906 | 0.15 | trans | ||
| rs11520713 | chr7 | 36419236 | SLC35E2 | 9906 | 0.17 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIF11 | 0.97 | 0.88 |
| BRIP1 | 0.97 | 0.84 |
| KIF15 | 0.97 | 0.87 |
| ASPM | 0.97 | 0.82 |
| KIF23 | 0.97 | 0.83 |
| CEP55 | 0.97 | 0.82 |
| SGOL1 | 0.97 | 0.76 |
| CDCA2 | 0.96 | 0.76 |
| HELLS | 0.96 | 0.79 |
| MELK | 0.96 | 0.82 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FBXO2 | -0.44 | -0.72 |
| HLA-F | -0.44 | -0.80 |
| SLC9A3R2 | -0.43 | -0.51 |
| PTH1R | -0.43 | -0.74 |
| C5orf53 | -0.43 | -0.72 |
| TNFSF12 | -0.43 | -0.70 |
| LHPP | -0.43 | -0.64 |
| AIFM3 | -0.42 | -0.75 |
| ALDOC | -0.42 | -0.72 |
| ASPHD1 | -0.42 | -0.60 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| WALLACE PROSTATE CANCER RACE DN | 88 | 42 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE DN | 209 | 137 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |