Summary ?
GeneID9917
SymbolFAM20B
Synonymsgxk1
Descriptionfamily with sequence similarity 20 member B
ReferenceMIM:611063|HGNC:HGNC:23017|Ensembl:ENSG00000116199|HPRD:13297|Vega:OTTHUMG00000035073
Gene typeprotein-coding
Map location1q25
Sherlock p-value0.848
Fetal beta-0.719
DMG1 (# studies)
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Frontal Cortex BA9
Nucleus accumbens basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg131152401178995597FAM20B3.73E-8-0.0081.08E-5DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FTL0.760.57
SEPX10.760.63
TSPAN310.760.60
C11orf590.750.69
C9orf230.740.57
SNAPIN0.740.60
C2orf280.740.58
TMEM1490.740.54
JTB0.740.56
SURF10.730.63
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BAT2D1-0.36-0.32
ANK3-0.35-0.28
LRP1B-0.34-0.33
BDP1-0.34-0.29
RBM25-0.34-0.31
PCLO-0.33-0.27
UPF2-0.33-0.29
EIF5B-0.32-0.34
BOD1L-0.31-0.25
MYSM1-0.31-0.28

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 11069All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191131All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212121All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
CHEN LIVER METABOLISM QTL CIS 9340All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway