Gene Page: XYLB
Summary ?
| GeneID | 9942 |
| Symbol | XYLB |
| Synonyms | - |
| Description | xylulokinase homolog (H. influenzae) |
| Reference | MIM:604049|HGNC:HGNC:12839|Ensembl:ENSG00000093217|HPRD:06812|Vega:OTTHUMG00000131294 |
| Gene type | protein-coding |
| Map location | 3p22-p21.3 |
| Pascal p-value | 0.001 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| UBR3 | 0.95 | 0.94 |
| FAM179B | 0.94 | 0.92 |
| DMXL2 | 0.93 | 0.92 |
| CHM | 0.93 | 0.92 |
| FBXL17 | 0.93 | 0.93 |
| USP32 | 0.93 | 0.93 |
| AKAP11 | 0.93 | 0.94 |
| RAB3GAP1 | 0.93 | 0.90 |
| ZDBF2 | 0.93 | 0.91 |
| DMXL1 | 0.92 | 0.92 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C1orf61 | -0.54 | -0.67 |
| AF347015.21 | -0.53 | -0.50 |
| EIF4EBP3 | -0.52 | -0.57 |
| RAB34 | -0.51 | -0.58 |
| ENHO | -0.51 | -0.57 |
| C1orf54 | -0.51 | -0.56 |
| FXYD1 | -0.51 | -0.50 |
| PLA2G5 | -0.51 | -0.49 |
| HIGD1B | -0.50 | -0.51 |
| TLCD1 | -0.49 | -0.49 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004856 | xylulokinase activity | TAS | 9763671 | |
| GO:0016740 | transferase activity | IEA | - | |
| GO:0016301 | kinase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006091 | generation of precursor metabolites and energy | TAS | 9763671 | |
| GO:0005975 | carbohydrate metabolic process | IEA | - | |
| GO:0005975 | carbohydrate metabolic process | TAS | 9763671 | |
| GO:0042732 | D-xylose metabolic process | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS | 28 | 17 | All SZGR 2.0 genes in this pathway |
| PEPPER CHRONIC LYMPHOCYTIC LEUKEMIA UP | 33 | 28 | All SZGR 2.0 genes in this pathway |
| FIRESTEIN PROLIFERATION | 175 | 125 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D UP | 139 | 95 | All SZGR 2.0 genes in this pathway |
| TAVAZOIE METASTASIS | 108 | 68 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
| OHGUCHI LIVER HNF4A TARGETS DN | 149 | 85 | All SZGR 2.0 genes in this pathway |