SZGR2

Summary ?

GeneID	996
Symbol	CDC27
Synonyms	ANAPC3\|APC3\|CDC27Hs\|D0S1430E\|D17S978E\|H-NUC\|HNUC\|NUC2
Description	cell division cycle 27
Reference	MIM:116946\|HGNC:HGNC:1728\|Ensembl:ENSG00000004897\|HPRD:00304\|Vega:OTTHUMG00000166429
Gene type	protein-coding
Map location	17q21.32
Pascal p-value	0.174
Sherlock p-value	0.015
Fetal beta	-0.463
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs11051641	chr12	32020255	CDC27	996		0.16		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ST3GAL1	0.82	0.84
SSBP3	0.82	0.79
TP53I11	0.80	0.93
AC127496.3	0.80	0.83
BCL7A	0.78	0.90
SEZ6	0.78	0.92
C14orf37	0.77	0.81
SOBP	0.77	0.90
SRGAP2	0.77	0.89
ATXN7L1	0.77	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SERPINB6	-0.60	-0.75
HEPN1	-0.57	-0.75
S100B	-0.57	-0.83
AP003117.1	-0.56	-0.68
AF347015.27	-0.56	-0.85
TSC22D4	-0.56	-0.77
HLA-F	-0.56	-0.75
AIFM3	-0.56	-0.75
AF347015.31	-0.56	-0.84
AF347015.33	-0.56	-0.85

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ANAPC1	APC1 \| MCPR \| TSG24	anaphase promoting complex subunit 1	Affinity Capture-Western Co-purification	BioGRID	11076961 \|12956947
ANAPC10	APC10 \| DKFZp564L0562 \| DOC1	anaphase promoting complex subunit 10	Affinity Capture-Western	BioGRID	12956947
ANAPC11	APC11 \| Apc11p \| HSPC214 \| MGC882	anaphase promoting complex subunit 11	Affinity Capture-Western	BioGRID	12956947
ANAPC4	APC4	anaphase promoting complex subunit 4	Affinity Capture-Western	BioGRID	12956947
ANAPC5	APC5	anaphase promoting complex subunit 5	-	HPRD,BioGRID	10922056
ANAPC7	APC7	anaphase promoting complex subunit 7	Affinity Capture-Western	BioGRID	12956947
APC2	APCL	adenomatosis polyposis coli 2	Affinity Capture-Western	BioGRID	12956947
BUB1B	BUB1beta \| BUBR1 \| Bub1A \| MAD3L \| SSK1 \| hBUBR1	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	-	HPRD,BioGRID	10477750
CDC16	APC6	cell division cycle 16 homolog (S. cerevisiae)	-	HPRD,BioGRID	9405394
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	Affinity Capture-Western Reconstituted Complex	BioGRID	9628895 \|9736712 \|9811605 \|12196507 \|12956947 \|14561775
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	-	HPRD	9736712 \|12196507
CDC23	APC8	cell division cycle 23 homolog (S. cerevisiae)	Affinity Capture-Western	BioGRID	12956947
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Reconstituted Complex	BioGRID	12956947
FZR1	CDC20C \| CDH1 \| FZR \| FZR2 \| HCDH \| HCDH1 \| KIAA1242	fizzy/cell division cycle 20 related 1 (Drosophila)	Cdh1 interacts with Cdc27.	BIND	15916961
FZR1	CDC20C \| CDH1 \| FZR \| FZR2 \| HCDH \| HCDH1 \| KIAA1242	fizzy/cell division cycle 20 related 1 (Drosophila)	-	HPRD,BioGRID	12797865
HOXC10	HOX3I \| MGC5259	homeobox C10	-	HPRD	12853486
MAD2L1	HSMAD2 \| MAD2	MAD2 mitotic arrest deficient-like 1 (yeast)	-	HPRD,BioGRID	9736712
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	-	HPRD,BioGRID	9499405 \|10939594
PIN1	DOD \| UBL5	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Pin1 interacts with Cdc27.	BIND	9499405
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	-	HPRD,BioGRID	9405394
SKIL	SNO \| SnoA \| SnoN	SKI-like oncogene	-	HPRD	11691834
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD,BioGRID	11691834
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	-	HPRD,BioGRID	11691834
SPATC1	MGC61633 \| SPATA15 \| SPERIOLIN	spermatogenesis and centriole associated 1	Affinity Capture-Western	BioGRID	15280373

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	138	98	All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION	86	59	All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	24	12	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE	85	46	All SZGR 2.0 genes in this pathway
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	72	38	All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	73	40	All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	64	34	All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	26	10	All SZGR 2.0 genes in this pathway
REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	22	9	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF THE APC C	23	10	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	212	129	All SZGR 2.0 genes in this pathway
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	28	12	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN	229	142	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
WAESCH ANAPHASE PROMOTING COMPLEX	12	7	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN	45	33	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 HELA	69	47	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN	169	102	All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN	185	111	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN	309	206	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR UP	178	111	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
OUILLETTE CLL 13Q14 DELETION UP	74	40	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M	216	124	All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS	206	127	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway

Gene Page: CDC27