Gene Page: DMTF1

Summary ?
GeneID9988
SymbolDMTF1
SynonymsDMP1|DMTF|MRUL|hDMP1
Descriptioncyclin D binding myb like transcription factor 1
ReferenceMIM:608491|HGNC:HGNC:14603|Ensembl:ENSG00000135164|HPRD:09770|Vega:OTTHUMG00000154135
Gene typeprotein-coding
Map location7q21
Pascal p-value0.128
Sherlock p-value0.222
Fetal beta1.074
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg00659421786781760DMTF11.03E-6-0.710.007DMG:Wockner_2014
cg08689931786781758DMTF12.887E-4-0.2320.039DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7972594chr1211724913DMTF199880.07trans
rs10491979chr1211727969DMTF199880.07trans
rs7882576chrX38501487DMTF199880.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C14orf1530.850.85
PANK20.850.85
ARMCX20.840.84
KLRAQ10.840.81
PPFIA20.830.84
NDEL10.830.83
C16orf450.820.80
TPM10.820.84
VPS410.820.82
KCTD20.820.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.66-0.53
MT-CO2-0.63-0.54
AF347015.31-0.63-0.55
AF347015.8-0.63-0.52
AF347015.2-0.62-0.51
MT-CYB-0.61-0.51
AF347015.15-0.60-0.51
AF347015.26-0.59-0.48
AF347015.27-0.59-0.51
METRN-0.59-0.59

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID FRA PATHWAY 3728All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 7060All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN 391222All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN 160101All SZGR 2.0 genes in this pathway
BILD SRC ONCOGENIC SIGNATURE 6238All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway