Gene Page: PPP4R1
Summary ?
| GeneID | 9989 |
| Symbol | PPP4R1 |
| Synonyms | MEG1|PP4(Rmeg)|PP4R1 |
| Description | protein phosphatase 4 regulatory subunit 1 |
| Reference | MIM:604908|HGNC:HGNC:9320|Ensembl:ENSG00000154845|Vega:OTTHUMG00000137466 |
| Gene type | protein-coding |
| Map location | 18p11.22 |
| Pascal p-value | 0.01 |
| Sherlock p-value | 0.205 |
| eGene | Cerebellum Myers' cis & trans |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4485437 | chr18 | 9837574 | PPP4R1 | 9989 | 0.15 | cis | ||
| rs9960096 | chr18 | 10346077 | PPP4R1 | 9989 | 0.16 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SOD1 | 0.90 | 0.92 |
| SNRPN | 0.88 | 0.90 |
| SNX17 | 0.86 | 0.88 |
| ATP6V1E1 | 0.86 | 0.87 |
| PKM2 | 0.86 | 0.87 |
| TMEM111 | 0.86 | 0.90 |
| SNURF | 0.86 | 0.86 |
| C17orf79 | 0.85 | 0.88 |
| BSCL2 | 0.84 | 0.86 |
| GHITM | 0.84 | 0.87 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF814 | -0.51 | -0.59 |
| SH3BP2 | -0.48 | -0.51 |
| ANKRD36 | -0.47 | -0.60 |
| ANKRD36B | -0.46 | -0.62 |
| TRIOBP | -0.46 | -0.48 |
| PLEKHG2 | -0.46 | -0.53 |
| FBN3 | -0.46 | -0.40 |
| AC005921.3 | -0.46 | -0.62 |
| SMTN | -0.45 | -0.49 |
| DCHS1 | -0.45 | -0.42 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| WINTER HYPOXIA UP | 92 | 57 | All SZGR 2.0 genes in this pathway |
| DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| TIEN INTESTINE PROBIOTICS 2HR DN | 88 | 53 | All SZGR 2.0 genes in this pathway |
| WANG ESOPHAGUS CANCER VS NORMAL DN | 101 | 66 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER DN | 514 | 319 | All SZGR 2.0 genes in this pathway |
| SESTO RESPONSE TO UV C5 | 46 | 36 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 STIMULATED | 1022 | 619 | All SZGR 2.0 genes in this pathway |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | All SZGR 2.0 genes in this pathway |
| IZADPANAH STEM CELL ADIPOSE VS BONE UP | 126 | 92 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S1 | 237 | 159 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |