SZGR2

Summary ?

GeneID	26122
Symbol	EPC2
Synonyms	EPC-LIKE
Description	enhancer of polycomb homolog 2
Reference	MIM:611000\|HGNC:HGNC:24543\|Ensembl:ENSG00000135999\|HPRD:13274\|Vega:OTTHUMG00000153739
Gene type	protein-coding
Map location	2q23.1
Pascal p-value	0.049
Sherlock p-value	0.642
Fetal beta	1.189
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGC128	Genome-wide Association Study	A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp	Genome-wide Association Study	GWAS
CV:PheWAS	Phenome-wide association studies (PheWAS)	157 SNPs associated with schizophrenia	2
GSMA_I	Genome scan meta-analysis	Psr: 0.023
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.02395

Section I. Genetics and epigenetics annotation

CV:PGC128

SNP ID	Chromosome	Position	Allele	P	Function	Gene	Up/Down Distance

CV:PheWAS

SNP ID	Chromosome	Position	Allele	P	Function	Gene	Up/Down Distance
rs4499362	2	149284866	null	1.804	EPC2	null
rs2121433	2	149274330	null	1.474	EPC2	null

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs1561519	chr2	35823020	EPC2	26122	0.19	trans
rs7591339	chr2	35825597	EPC2	26122	0.19	trans
rs7570146	chr2	35844751	EPC2	26122	0.19	trans
rs1439691	chr2	35851281	EPC2	26122	0.19	trans
rs1257641	chr14	99480394	EPC2	26122	0.2	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0006281	DNA repair	IEA		-
GO:0016568	chromatin modification	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
WAMUNYOKOLI OVARIAN CANCER LMP DN	199	124	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP	344	180	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN	159	105	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-130/301	1109	1115	1A	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
				hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-181	652	659	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	291	298	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-188	596	602	m8	hsa-miR-188	CAUCCCUUGCAUGGUGGAGGGU
miR-19	251	257	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	251	257	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-190	1178	1185	1A,m8	hsa-miR-190	UGAUAUGUUUGAUAUAUUAGGU
miR-194	1132	1138	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-194	1132	1138	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-196	174	180	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	174	180	m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-203.1	535	541	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-224	1044	1050	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367	870	876	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-26	256	262	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
				hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
				hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-30-5p	359	366	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-331	589	595	1A	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-382	1122	1128	m8	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
miR-384	714	720	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-384	714	720	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-433-3p	304	310	m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-494	488	494	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-494	488	494	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	1100	1106	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-543	1096	1102	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EPC2