Gene Page: NMUR2

Summary ?
GeneID56923
SymbolNMUR2
SynonymsFM-4|FM4|NMU-R2|NMU2R|TGR-1|TGR1
Descriptionneuromedin U receptor 2
ReferenceMIM:605108|HGNC:HGNC:16454|Ensembl:ENSG00000132911|HPRD:12003|Vega:OTTHUMG00000130131
Gene typeprotein-coding
Map location5q33.1
Pascal p-value0.005
Fetal beta-0.169
eGeneCortex
Frontal Cortex BA9

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGC128Genome-wide Association StudyA multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.00459 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs79212538chr5151993104TG3.843E-8intergenicNMUR2,LINC01470dist=208264;dist=5421


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001607neuromedin U receptor activityIDA10887190 
GO:0004872receptor activityIEA-
GO:0005525GTP bindingIDA10899166 
GO:0005229intracellular calcium activated chloride channel activityIDA10899166 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentIEPBrain (GO term level: 6)10899166 
GO:0007218neuropeptide signaling pathwayTASNeurotransmitter (GO term level: 8)10894543 
GO:0019226transmission of nerve impulseIEPneuron (GO term level: 5)10899166 
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IDA10899166 
GO:0007204elevation of cytosolic calcium ion concentrationIDA10899166 
GO:0007165signal transductionIEA-
GO:0048016inositol phosphate-mediated signalingIDA10899166 
GO:0007631feeding behaviorTAS10894543 
GO:0006816calcium ion transportIDA10899166 
GO:0006940regulation of smooth muscle contractionNAS10887190 
GO:0043006calcium-dependent phospholipase A2 activationIDA10899166 
GO:0050482arachidonic acid secretionIDA10887190 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIDA10899166 
GO:0005886plasma membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway