deTS Results for Diagnoses - main ICD10: L91 Hypertrophic disorders of skin

Traits Information:

Trait ID:

312

L91
Diagnoses - main ICD10: L91 Hypertrophic disorders of skin
UK Biobank (UKBB)
Neale Lab, 2018
# cases = 615 | # controls = 360579
# SNPs = 8526569 | # genes = 21891
1.014
p (gene) < 0.05:  # TAGs = 1129
p (gene) < 0.01:  # TAGs = 234
p (gene) < 0.001:  # TAGs = 24
p (gene) < 1.0E-4:  # TAGs = 6
p (gene) < 1.0E-5: # TAGs = 3

Manhattan Plot of All SNPs in the GWAS




Manhattan Plot of All Genes in the GWAS


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deTS Enrichment Analysis Using the GTEx Panel


p < 0.05 p < 0.01 p < 0.001 0.2070.05060.5140.3780.2580.7130.8650.8650.9010.8220.8220.8650.8220.7710.650.8220.650.650.1630.5830.05060.2580.06990.5140.1250.1250.2070.7130.2580.05060.1630.2070.7710.7130.5140.1630.7130.930.9680.9010.06870.8220.650.5830.1630.5830.7130.4390.7380.05950.05950.01380.9360.9950.9780.9780.9780.9990.9990.9780.7380.9780.9360.5920.7380.7380.8560.4390.5920.5920.7380.3010.110.190.7380.8560.5920.9360.7380.190.5920.4390.5920.7380.4390.8560.7380.2990.5920.4390.9990.5920.9360.4390.5120.5120.030.1530.1530.1531.00.5121.01.01.01.00.1530.1530.5120.1530.030.031.00.5121.00.5121.00.5121.00.5120.1530.5121.01.01.01.00.5121.00.5120.5120.5120.5121.01.01.00.1531.01.00.5121.00.153Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel


p < 0.05 p < 0.01 p < 0.001 0.4150.1060.4150.4850.8920.4150.5480.5520.8040.7520.1830.1420.8890.1420.3490.4150.3490.1070.3490.4150.1420.9210.1070.1810.4120.8530.4150.01950.8530.3490.4780.2320.4150.1810.6220.6220.4850.8920.4850.4850.1830.05780.6250.9650.1560.2550.390.9720.8280.5430.920.9720.6960.5430.6970.1560.8260.5430.1560.390.08680.6970.6970.390.04470.6950.8280.3880.6960.9210.9720.1560.390.9210.540.02140.9210.8270.8270.2550.390.6970.2570.390.02140.5430.8280.6971.00.4580.01931.00.4590.4591.01.00.4581.01.01.00.1171.00.1181.00.1181.00.1180.4590.1180.4581.01.01.01.00.4590.4590.4591.00.4580.002190.4591.01.01.01.01.00.4591.01.01.00.4591.0Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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