deTS Results for Diagnoses - main ICD10: M62 Other disorders of muscle

Traits Information:

Trait ID:

457

M62
Diagnoses - main ICD10: M62 Other disorders of muscle
UK Biobank (UKBB)
Neale Lab, 2018
# cases = 343 | # controls = 360851
# SNPs = 7596473 | # genes = 21889
1.002
p (gene) < 0.05:  # TAGs = 1152
p (gene) < 0.01:  # TAGs = 234
p (gene) < 0.001:  # TAGs = 16
p (gene) < 1.0E-4:  # TAGs = 1
p (gene) < 1.0E-5: # TAGs = 0

Manhattan Plot of All SNPs in the GWAS




Manhattan Plot of All Genes in the GWAS


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deTS Enrichment Analysis Using the GTEx Panel


p < 0.05 p < 0.01 0.2140.1690.8760.9890.8340.3260.5280.7840.7270.7840.6650.5980.4580.7270.7270.7840.8760.910.2140.1690.01170.5280.01750.390.004890.7270.6650.7270.5280.7270.5980.05240.8340.7840.9830.2140.7270.03710.6650.5280.5946.73E-40.5980.2140.3260.05240.02580.7720.7720.9480.9480.9480.03940.3430.6350.3430.3430.7720.4850.07570.3430.7720.2240.2240.6350.4850.9830.07571.00.1350.9962.0E-50.3430.1350.07570.7720.4850.3430.01910.7720.7720.8790.008620.7720.3430.7720.6350.07510.03940.07570.07570.9960.3430.635Adipose - SubcutaneousAdipose - Visceral (Omentum)Artery - AortaArtery - CoronaryArtery - TibialBrain - AmygdalaBrain - Anterior cingulate cortex (BA24)Brain - Caudate (basal ganglia)Brain - Cerebellar HemisphereBrain - CerebellumBrain - CortexBrain - Frontal Cortex (BA9)Brain - HippocampusBrain - HypothalamusBrain - Nucleus accumbens (basal ganglia)Brain - Putamen (basal ganglia)Brain - Spinal cord (cervical c-1)Brain - Substantia nigraBreast - Mammary TissueColon - SigmoidColon - TransverseEsophagus - Gastroesophageal JunctionEsophagus - MucosaEsophagus - MuscularisStomachHeart - Atrial AppendageHeart - Left VentricleAdrenal GlandKidney-CortexLiverLungMinor Salivary GlandMuscle - SkeletalNerve - TibialOvaryPancreasPituitaryProstateSkin - Not Sun Exposed (Suprapubic)Skin - Sun Exposed (Lower leg)Small Intestine - Terminal IleumSpleenTestisThyroidUterusVaginaWhole Blood

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deTS Enrichment Analysis Using the ENCODE Panel


p < 0.05 p < 0.01 0.1130.1110.9030.3640.3640.8220.8630.240.2970.30.5740.9540.4250.0840.3640.4320.2430.1130.5740.5740.7090.7640.8220.970.2970.5030.03020.9810.9030.970.6370.6430.3640.640.2970.7660.4320.9030.03020.8220.0610.9810.2430.5030.5960.5940.7410.4430.1920.4430.9360.3030.1120.5960.4430.9950.7390.1120.8590.1920.8590.01420.4430.1920.4430.440.8590.5940.3030.5960.4430.4430.3040.5960.3010.5960.03040.4420.1910.9370.8590.9790.1120.8590.01420.9950.5960.741Subcutaneous Adipose TissueOmental Fat PadThoracic AortaCerebellumFrontal CortexSpinal CordOccipital LobeParietal LobeTemporal LobeDiencephalonBreast EpitheliumCamera type eyeSigmoid ColonTransverse ColonEsophagus Muscularis MucosaEsophagus Squamous EpitheliumGastroesophageal SphincterStomachHeartHeart - Left VentricleRight Atrium Auricular RegionAdrenal GlandMetanephrosLiverRight Lobe of LiverLungUpper Lobe of Left LungSkeletal Muscle TissueGastrocnemius MedialisTongueTibial NerveOvaryBody of PancreasPeyer's PatchProstate GlandSuprapubic SkinLower Leg SkinSkin of BodySpleenTestisThyroid GlandUmbilical CordUrinary BladderUterus

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