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Found 38 literature records

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Entrez ID	Description
1050	may function as a tumor suppressor that is mutated during tumorigenesis. Abnormalties in C/EBPalpha function contribute to the development of malignancies in a variety of tisues.
1029	"The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia."
7490	Role of the WT1 tumor suppressor in normal hematopoiesis in embryo and adult cell lineages.
1030	The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells.
2272	"FHIT methylation was accumulated through the disease progression of MDS and AML, and the role of the FHIT gene as a tumor suppressor seemed different in AML and MDS"
4763	"NF1 tumor suppressor gene is a direct transcriptional target of RUNX1 and the t(8;21) fusion protein, suggesting that suppression of NF1 expression contributes to the molecular pathogenesis of acute myeloid leukemia ."
6688	an upstream regulatory element has an essential role in orchestrating the dynamic PU.1 expression pattern required for lymphoid development and tumor suppression.
3394	Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.
1052	C/EBPdelta is a novel tumor suppressor gene in acute myeloid leukemia that is silenced by promoter methylation.
1030	Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors.
8013	NOR-1 is a critical tumor suppressor of myeloid leukemogenesis that is downregulated in leukemic blasts from acute myeloid leukemia patients.
3164	NUR77 is a critical tumor suppressor of myeloid leukemogenesis that is downregulated in leukemic blasts from acute myeloid leukemia patients.
8848	TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD
4869	Npm1 acts as a haploinsufficient tumor suppressor in the hematopoietic compartment
160728	"In acute myeloid leukemia with mixed lineage leukemia partial tandem duplication, the SLC5A8 tumor suppressor gene promoter was more frequently hypermethylated."
5728	[Expression of tumor suppressor gene pten in patients with myelodysplastic syndrome and acute myeloid leukemia].
407024	MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
5371	Results provide insight into a dynamic pool of cytoplasmic nucleoporins that form a complex with the tumor suppressor protein PML during the G1 phase of the cell cycle.
23705	"These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins."
7078	"These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins."
84707	"These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins."
7474	"WNT5A, a putative tumor suppressor gene in acute myeloid leukemia (AML), is silenced by methylation in this disease and that this epigenetic event is associated with upregulation of CYCLIN D1 expression."
54790	"With diverse genetic methods, TET2 on chromosome 4q24 was identified as candidate tumor suppressor gene."
7157	the ability of p53 to limit aberrant self-renewal contributes to its tumor suppressor activity
6794	The LKB1/AMPK/TSC tumor suppressor axis is functional in acute myeloid leukemia.
84295	PHF6 as a tumor suppressor gene mutated in acute myeloid leukemias (AML) and extend the role of this X-linked tumor suppressor gene in the pathogenesis of hematologic tumors.
10217	"MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia."
2322	"The WT FLT3 allele seemingly functions as a tumor suppressor, attenuating the function of the FLT3/ITD allele in leukemia harboring FLT3/ITD mutations."
11010	Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis.
1437	A possible tumor-suppressor role of GM-CSF in RUNX1-ETO leukemia.
2322	excessive Flt3 expression has growth-suppressive properties in several human cancer cell lines
442915	"miR-370 may function as a tumor suppressor by targeting FoxM1, and the epigenetic silence of miR-370 thus leads to derepression of FoxM1 expression and consequently contributes to AML development and progression."
574453	miR-495 likely functions as a tumor suppressor in acute myeloid leukemia with MLL rearrangements.
51523	Lack of promoter hypermethylation or somatic mutations are found in the potential tumor suppressor CXXC5 in myelodysplastic syndromes or acute myeloid leukemia with deletion 5q.
1523	"Data indicate CUX1 as a conserved, haploinsufficient tumor suppressor frequently deleted in myeloid neoplasms."
57167	The mechanism of SALL4 in promoting leukemogenesis is at least in part mediated by its repression of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) through its interaction with a histone deacetylase (HDAC) complex.
58508	this mouse model functionally validates MLL3 as a haploinsufficient 7q tumor suppressor and suggests a therapeutic option for this aggressive disease.
1500	Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumor suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12.