TissGeneSummary for SYCE1L |
Gene summary |
Basic gene information | Gene symbol | SYCE1L |
Gene name | synaptonemal complex central element protein 1-like | |
Synonyms | MRP2 | |
Cytomap | UCSC genome browser: 16q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001129979.1, | |
Description | meiosis-related protein | |
Modification date | 20141208 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000205078 | ||
Vega : OTTHUMG00000176809 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SYCE1L | |
BioGPS: 100130958 | ||
Pathway | NCI Pathway Interaction Database: SYCE1L | |
KEGG: SYCE1L | ||
REACTOME: SYCE1L | ||
Pathway Commons: SYCE1L | ||
Context | iHOP: SYCE1L | |
ligand binding site mutation search in PubMed: SYCE1L | ||
UCL Cancer Institute: SYCE1L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SYCE1L | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SYCE1L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -2.830208165 | -1.770760796 | -1.059447368 | 2.70E-07 | 7.77E-07 |
KIRP | 0.636972427 | -1.436768198 | 2.073740625 | 1.07E-06 | 5.44E-06 |
THCA | 1.044669355 | -0.342964543 | 1.387633898 | 1.05E-07 | 4.56E-07 |
KICH | -1.530879323 | -0.447835323 | -1.083044 | 0.0105 | 0.018845277 |
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TissGene-miRNA for SYCE1L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SYCE1L |
TissGeneSNV for SYCE1L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P210T | COAD | 4 |
p.P210T | READ | 3 |
p.P210T | BRCA | 2 |
p.E164K | DLBC | 1 |
p.D129G | CESC | 1 |
p.R178Q | BRCA | 1 |
p.P210T | LGG | 1 |
p.E41V | KIRC | 1 |
p.D129G | LIHC | 1 |
p.E150D | THYM | 1 |
p.Q39R | COAD | 1 |
p.R152H | THYM | 1 |
p.P210T | PRAD | 1 |
p.S25T | BRCA | 1 |
p.Q108K | LIHC | 1 |
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TissGeneCNV for SYCE1L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SYCE1L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SYCE1L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SYCE1L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SYCE1L |
TissGeneDrug for SYCE1L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SYCE1L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0022350 | Jaundice, Chronic Idiopathic | 19 | BeFree |
umls:C0268307 | Conjugated hyperbilirubinemia | 10 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 5 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0014544 | Epilepsy | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C2239176 | Liver carcinoma | 3 | BeFree |
umls:C0001418 | Adenocarcinoma | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0019158 | Hepatitis | 2 | BeFree |
umls:C0019159 | Hepatitis A | 2 | BeFree |
umls:C0020433 | Hyperbilirubinemia | 2 | BeFree |
umls:C0025202 | melanoma | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
umls:C0005398 | Cholestasis, Extrahepatic | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0008312 | Primary biliary cirrhosis | 1 | BeFree |
umls:C0008370 | Cholestasis | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0019196 | Hepatitis C | 1 | BeFree |
umls:C0022354 | Jaundice, Obstructive | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0025500 | Mesothelioma | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0030286 | Pancreatic Diseases | 1 | BeFree |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0086692 | Benign Neoplasm | 1 | BeFree |
umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
umls:C0206681 | Adenocarcinoma, Clear Cell | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0345967 | Malignant mesothelioma | 1 | BeFree |
umls:C0376544 | Hematopoietic Neoplasms | 1 | BeFree |
umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |