TissGeneSummary for C7orf72 |
Gene summary |
Basic gene information | Gene symbol | C7orf72 |
Gene name | chromosome 7 open reading frame 72 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7p12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001161834.2, | |
Description | uncharacterized protein C7orf72 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C7orf72 | |
BioGPS: 100130988 | ||
Pathway | NCI Pathway Interaction Database: C7orf72 | |
KEGG: C7orf72 | ||
REACTOME: C7orf72 | ||
Pathway Commons: C7orf72 | ||
Context | iHOP: C7orf72 | |
ligand binding site mutation search in PubMed: C7orf72 | ||
UCL Cancer Institute: C7orf72 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C7orf72 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C7orf72 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for C7orf72 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C7orf72 |
TissGeneSNV for C7orf72 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D82Y | READ | 1 |
p.K229N | COAD | 1 |
p.S18T | LIHC | 1 |
p.P30T | UCEC | 1 |
p.T129I | ACC | 1 |
p.F312V | DLBC | 1 |
p.T326I | UCEC | 1 |
p.R98Q | KIRC | 1 |
p.R98W | CESC | 1 |
p.T358I | COAD | 1 |
p.L183F | READ | 1 |
p.G114C | COAD | 1 |
p.N52T | ESCA | 1 |
p.R280I | UCEC | 1 |
p.F375L | COAD | 1 |
p.D234V | LIHC | 1 |
p.P72S | LIHC | 1 |
p.A232E | THYM | 1 |
p.E25Q | UCEC | 1 |
p.D407Y | ESCA | 1 |
p.T147A | LIHC | 1 |
p.G371S | READ | 1 |
p.S302A | KIRP | 1 |
p.L35I | COAD | 1 |
p.P42S | COAD | 1 |
p.S108P | COAD | 1 |
p.A348V | UCEC | 1 |
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TissGeneCNV for C7orf72 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C7orf72 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-J9-A8CP-01A | ZNF716-C7orf72 | Out-of-Frame | chr7:57510033 | chr7:50191045 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AQ-A04L-01B | IGHMBP2-C7orf72 | Out-of-frame | Chr11:68685351 | Chr7:50179736 |
TCGAfusionPortal | PRADA | PRAD | TCGA-J9-A8CP-01A | ZNF716-C7orf72 | Out-of-frame | Chr7:57510033 | Chr7:50191046 |
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TissGeneNet for C7orf72 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C7orf72 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C7orf72 |
TissGeneDrug for C7orf72 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C7orf72 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |