TissGeneSummary for PCSK6 |
Gene summary |
Basic gene information | Gene symbol | PCSK6 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PCSK6 | |
BioGPS: 100507472 | ||
Pathway | NCI Pathway Interaction Database: PCSK6 | |
KEGG: PCSK6 | ||
REACTOME: PCSK6 | ||
Pathway Commons: PCSK6 | ||
Context | iHOP: PCSK6 | |
ligand binding site mutation search in PubMed: PCSK6 | ||
UCL Cancer Institute: PCSK6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of PCSK6 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PCSK6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.881433475 | 0.635798525 | -2.517232 | 5.61E-12 | 5.65E-11 |
COAD | 1.548579294 | 2.79956391 | -1.250984615 | 7.25E-08 | 5.24E-07 |
THCA | -3.448943848 | -1.181094695 | -2.267849153 | 4.13E-24 | 4.57E-22 |
PRAD | 1.882960064 | -0.239476475 | 2.122436538 | 1.61E-16 | 3.01E-14 |
KIRP | -1.918301475 | 0.4251454 | -2.343446875 | 5.56E-06 | 2.43E-05 |
KIRC | 3.818826303 | 0.68106797 | 3.137758333 | 1.39E-26 | 1.93E-25 |
LIHC | 4.612394525 | 5.748850525 | -1.136456 | 3.42E-05 | 0.000129843 |
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TissGene-miRNA for PCSK6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-9-5p | MIMAT0000441 | 0.021 | -0.3 | 60 |
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TissGeneMut for PCSK6 |
TissGeneSNV for PCSK6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E141K | SKCM | 2 |
p.A343V | LUAD | 1 |
p.R319Q | LGG | 1 |
p.A482S | LUAD | 1 |
p.P212L | SKCM | 1 |
p.E674K | LUSC | 1 |
p.R236Q | LUSC | 1 |
p.S642Y | UCEC | 1 |
p.R180W | LUAD | 1 |
p.R552Q | ESCA | 1 |
p.G317W | BLCA | 1 |
p.Q516* | UCEC | 1 |
p.E491* | UCEC | 1 |
p.Q334* | SKCM | 1 |
p.E673* | BLCA | 1 |
p.R144Q | SKCM | 1 |
p.E775K | SKCM | 1 |
p.E882* | ESCA | 1 |
p.K175N | CESC | 1 |
p.R408C | LGG | 1 |
p.S419P | GBM | 1 |
p.S548* | BRCA | 1 |
p.D808E | SKCM | 1 |
p.G251R | SKCM | 1 |
p.C799R | SKCM | 1 |
p.P318L | STAD | 1 |
p.D576N | BLCA | 1 |
p.Q133* | SKCM | 1 |
p.T638S | UCEC | 1 |
p.D873Y | LUAD | 1 |
p.R962H | STAD | 1 |
p.R647Q | HNSC | 1 |
p.E598K | SKCM | 1 |
p.G769E | UCEC | 1 |
p.D461Y | LUAD | 1 |
p.C411F | LUAD | 1 |
p.R768H | LUAD | 1 |
p.V368I | UCEC | 1 |
p.R248S | GBM | 1 |
p.E616K | HNSC | 1 |
p.E586D | LUAD | 1 |
p.E103G | SKCM | 1 |
p.E587K | BLCA | 1 |
p.T602I | SKCM | 1 |
p.E650Q | HNSC | 1 |
p.A467V | GBM | 1 |
p.L215P | STAD | 1 |
p.N620I | SKCM | 1 |
p.R151Q | THCA | 1 |
p.R648Q | HNSC | 1 |
p.C411Y | CHOL | 1 |
p.E287K | BLCA | 1 |
p.R236Q | SKCM | 1 |
p.D577N | BLCA | 1 |
p.E669K | LUSC | 1 |
p.G345V | LUSC | 1 |
p.G316W | BLCA | 1 |
p.R645H | CESC | 1 |
p.R953Q | SKCM | 1 |
p.A430D | LIHC | 1 |
p.V668M | LUSC | 1 |
p.E587D | LUAD | 1 |
p.Y109C | PRAD | 1 |
p.R181W | LUAD | 1 |
p.R949Q | ESCA | 1 |
p.K135R | LUAD | 1 |
p.D225N | SKCM | 1 |
p.Y393H | STAD | 1 |
p.T521M | BRCA | 1 |
p.E887K | BLCA | 1 |
p.E287D | STAD | 1 |
p.P878A | BLCA | 1 |
p.F127S | BLCA | 1 |
p.A250V | TGCT | 1 |
p.R767H | LUAD | 1 |
p.D357N | SKCM | 1 |
p.N259H | UCEC | 1 |
p.F325L | LUAD | 1 |
p.P654S | SKCM | 1 |
p.E617K | HNSC | 1 |
p.D299N | STAD | 1 |
p.D282N | STAD | 1 |
p.R898* | UCEC | 1 |
p.R647W | THCA | 1 |
p.G351R | PAAD | 1 |
p.P635R | SKCM | 1 |
p.M424I | SKCM | 1 |
p.L448R | STAD | 1 |
p.G466D | SKCM | 1 |
p.E672* | BLCA | 1 |
p.S646P | BRCA | 1 |
p.C179F | KIRC | 1 |
p.R191S | LUAD | 1 |
p.P317L | BLCA | 1 |
p.G192C | LUAD | 1 |
p.D620N | SKCM | 1 |
p.K596R | HNSC | 1 |
p.E586K | BLCA | 1 |
p.D873N | GBM | 1 |
p.Y297C | UCS | 1 |
p.H849Y | CESC | 1 |
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TissGeneCNV for PCSK6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PCSK6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF846664 | RPL22-PCSK6 | chr1:6246042 | chr15:101870984 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A0FZ-01A | PCSK6-LINS | In-Frame | chr15:101983760 | chr15:101114446 |
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TissGeneNet for PCSK6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PCSK6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PCSK6 |
TissGeneDrug for PCSK6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PCSK6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0178874 | Tumor Progression | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
umls:C0003850 | Arteriosclerosis | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0004153 | Atherosclerosis | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0019693 | HIV Infections | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0037286 | Skin Neoplasms | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0150055 | Chronic pain | 1 | BeFree |
umls:C0231749 | Knee pain | 1 | BeFree |
umls:C0280100 | Solid tumour | 1 | BeFree |
umls:C0409959 | Osteoarthritis, Knee | 1 | BeFree |
umls:C0476254 | Dyslexia | 1 | BeFree |
umls:C0553723 | Squamous cell carcinoma of skin | 1 | BeFree |
umls:C0555198 | Malignant Glioma | 1 | BeFree |
umls:C0577631 | Carotid Atherosclerosis | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |