TissGeneSummary for FAM57B |
Gene summary |
Basic gene information | Gene symbol | FAM57B |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM57B | |
BioGPS: 100996332 | ||
Pathway | NCI Pathway Interaction Database: FAM57B | |
KEGG: FAM57B | ||
REACTOME: FAM57B | ||
Pathway Commons: FAM57B | ||
Context | iHOP: FAM57B | |
ligand binding site mutation search in PubMed: FAM57B | ||
UCL Cancer Institute: FAM57B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of FAM57B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM57B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -1.623600345 | -3.12889097 | 1.505290625 | 1.57E-06 | 7.64E-06 |
BRCA | 0.014383153 | -1.727693163 | 1.742076316 | 7.25E-14 | 3.48E-13 |
LUSC | -1.899379695 | -2.926481656 | 1.027101961 | 1.39E-05 | 3.11E-05 |
LIHC | -1.85130997 | -3.29692797 | 1.445618 | 2.50E-08 | 2.01E-07 |
THCA | -1.916130376 | -2.993603258 | 1.077472881 | 2.70E-10 | 1.69E-09 |
LUAD | -1.709671142 | -2.964602176 | 1.254931034 | 4.49E-07 | 1.56E-06 |
KIRC | -2.148164581 | -3.22244097 | 1.074276389 | 3.83E-09 | 1.21E-08 |
HNSC | -1.431993877 | 0.0579131 | -1.489906977 | 0.00716 | 0.018474771 |
COAD | -2.231904431 | -1.200200585 | -1.031703846 | 0.000129 | 0.000455135 |
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TissGene-miRNA for FAM57B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM57B |
TissGeneSNV for FAM57B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P164S | SKCM | 2 |
p.W150X | SKCM | 1 |
p.E143K | UCS | 1 |
p.R168H | ESCA | 1 |
p.R217C | UVM | 1 |
p.S62F | HNSC | 1 |
p.R123H | LUAD | 1 |
p.W150* | SKCM | 1 |
p.Q180* | SKCM | 1 |
p.A238T | COAD | 1 |
p.R168S | LUAD | 1 |
p.S117R | LUAD | 1 |
p.W213* | SKCM | 1 |
p.G104R | SKCM | 1 |
p.G193R | PRAD | 1 |
p.R254H | LAML | 1 |
p.H98Q | LUSC | 1 |
p.Q180X | SKCM | 1 |
p.K128R | LGG | 1 |
p.D156N | STAD | 1 |
p.G8W | LIHC | 1 |
p.P170L | BRCA | 1 |
p.G107E | HNSC | 1 |
p.R151* | LAML | 1 |
p.F171L | BLCA | 1 |
p.F171L | SKCM | 1 |
p.A112S | LUSC | 1 |
p.S62F | SKCM | 1 |
p.L146F | COAD | 1 |
p.T169R | OV | 1 |
p.V172A | PRAD | 1 |
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TissGeneCNV for FAM57B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM57B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM57B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM57B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM57B |
TissGeneDrug for FAM57B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM57B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |