TissGeneSummary for CDH16 |
Gene summary |
Basic gene information | Gene symbol | CDH16 |
Gene name | cadherin 16, KSP-cadherin | |
Synonyms | - | |
Cytomap | UCSC genome browser: 16q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001204744.1, NM_001204745.1,NM_001204746.1,NM_004062.3, | |
Description | KSP-cadherincadherin-16kidney-specific cadherin | |
Modification date | 20141207 | |
dbXrefs | MIM : 603118 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166589 | ||
HPRD : 11929 | ||
Vega : OTTHUMG00000137518 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDH16 | |
BioGPS: 1014 | ||
Pathway | NCI Pathway Interaction Database: CDH16 | |
KEGG: CDH16 | ||
REACTOME: CDH16 | ||
Pathway Commons: CDH16 | ||
Context | iHOP: CDH16 | |
ligand binding site mutation search in PubMed: CDH16 | ||
UCL Cancer Institute: CDH16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of CDH16 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CDH16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 7.755643906 | 10.10535016 | -2.34970625 | 7.03E-11 | 8.47E-10 |
LUAD | -3.817153292 | -1.920672258 | -1.896481034 | 4.16E-15 | 4.30E-14 |
THCA | 0.786751004 | 6.533856088 | -5.747105085 | 3.48E-23 | 2.49E-21 |
KIRC | 7.230795989 | 9.897962656 | -2.667166667 | 8.27E-31 | 1.72E-29 |
KICH | 8.026736156 | 10.01022016 | -1.983484 | 0.0023 | 0.004672074 |
PRAD | -4.498372921 | -3.357392152 | -1.140980769 | 0.000493 | 0.001742607 |
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TissGene-miRNA for CDH16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CDH16 |
TissGeneSNV for CDH16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R164* | STAD | 2 |
p.E480K | SKCM | 2 |
p.E436K | SKCM | 2 |
p.E383K | SKCM | 2 |
p.R164X | STAD | 2 |
p.E339K | SKCM | 2 |
p.R484H | UCEC | 1 |
p.P574L | SKCM | 1 |
p.R311X | ACC | 1 |
p.P644R | BLCA | 1 |
p.P124T | GBM | 1 |
p.E88K | BLCA | 1 |
p.E281D | OV | 1 |
p.R679H | ACC | 1 |
p.T619I | SKCM | 1 |
p.A317V | PRAD | 1 |
p.A317V | BLCA | 1 |
p.R86Q | HNSC | 1 |
p.G189E | SKCM | 1 |
p.V56M | LGG | 1 |
p.R242C | SKCM | 1 |
p.A489V | GBM | 1 |
p.A64T | COAD | 1 |
p.E87X | STAD | 1 |
p.G447S | SKCM | 1 |
p.H682Y | DLBC | 1 |
p.G508E | LGG | 1 |
p.A446T | STAD | 1 |
p.I234T | STAD | 1 |
p.V712L | LUSC | 1 |
p.L348F | STAD | 1 |
p.G195E | SKCM | 1 |
p.L203P | BLCA | 1 |
p.P591L | SKCM | 1 |
p.E28K | HNSC | 1 |
p.G313S | SKCM | 1 |
p.D340N | HNSC | 1 |
p.R408* | ACC | 1 |
p.D462N | SKCM | 1 |
p.G35E | SKCM | 1 |
p.D231N | SKCM | 1 |
p.D328N | SKCM | 1 |
p.Y577X | SKCM | 1 |
p.E521K | SKCM | 1 |
p.V795I | SKCM | 1 |
p.D821N | BLCA | 1 |
p.A489V | PRAD | 1 |
p.E149Q | BLCA | 1 |
p.S452F | SKCM | 1 |
p.G216D | SKCM | 1 |
p.K814E | KICH | 1 |
p.P141H | UCEC | 1 |
p.R153Q | LUAD | 1 |
p.E616K | SKCM | 1 |
p.V698I | SKCM | 1 |
p.L207I | COAD | 1 |
p.V573A | UCEC | 1 |
p.R484C | STAD | 1 |
p.R717C | BLCA | 1 |
p.P38S | SKCM | 1 |
p.T729N | LUSC | 1 |
p.P109S | LGG | 1 |
p.A51T | THCA | 1 |
p.P351L | LUSC | 1 |
p.P562T | LUAD | 1 |
p.F147L | BLCA | 1 |
p.G313D | SKCM | 1 |
p.R140K | SKCM | 1 |
p.Y674* | UCEC | 1 |
p.D331E | BLCA | 1 |
p.P460L | SKCM | 1 |
p.D815N | SKCM | 1 |
p.S355F | SKCM | 1 |
p.V529G | LGG | 1 |
p.P671L | SKCM | 1 |
p.P38H | SKCM | 1 |
p.E436K | PRAD | 1 |
p.R594Q | LAML | 1 |
p.Q533H | BLCA | 1 |
p.I442T | STAD | 1 |
p.R86Q | SKCM | 1 |
p.D543N | SKCM | 1 |
p.E119D | UCEC | 1 |
p.I442F | BLCA | 1 |
p.Y674* | SKCM | 1 |
p.P45L | LUAD | 1 |
p.E87* | STAD | 1 |
p.P816S | BLCA | 1 |
p.D215N | SKCM | 1 |
p.E434* | BRCA | 1 |
p.E339X | COAD | 1 |
p.D347Y | READ | 1 |
p.L646M | ESCA | 1 |
p.G544S | SKCM | 1 |
p.A425T | STAD | 1 |
p.E250D | COAD | 1 |
p.R776C | STAD | 1 |
p.E519K | SKCM | 1 |
p.A225T | SKCM | 1 |
p.E424K | SKCM | 1 |
p.P30S | SKCM | 1 |
p.R339C | SKCM | 1 |
p.D718N | SKCM | 1 |
p.T226I | STAD | 1 |
p.P562L | HNSC | 1 |
p.G216S | SKCM | 1 |
p.P494L | SKCM | 1 |
p.L163F | SARC | 1 |
p.E293Q | BRCA | 1 |
p.R164Q | LUAD | 1 |
p.S458R | UCEC | 1 |
p.R679H | THYM | 1 |
p.D640N | SKCM | 1 |
p.E155K | SKCM | 1 |
p.L41Q | LUAD | 1 |
p.E616K | HNSC | 1 |
p.G286E | SKCM | 1 |
p.R48C | LUSC | 1 |
p.E329D | UCEC | 1 |
p.N120K | LUAD | 1 |
p.P319H | UCEC | 1 |
p.V558M | STAD | 1 |
p.T666S | UCS | 1 |
p.P395R | OV | 1 |
p.R408X | ACC | 1 |
p.A128T | SKCM | 1 |
p.A620T | HNSC | 1 |
p.T467S | LUAD | 1 |
p.H275N | UCEC | 1 |
p.P465H | LUSC | 1 |
p.V276I | READ | 1 |
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TissGeneCNV for CDH16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CDH16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CDH16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CDH16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CDH16 |
TissGeneDrug for CDH16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CDH16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree,LHGDN |
umls:C0549473 | Thyroid carcinoma | 2 | BeFree |
umls:C1510502 | Oxyphilic Adenoma | 2 | BeFree,LHGDN |
umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
umls:C0027660 | Neoplasms, Glandular and Epithelial | 1 | LHGDN |
umls:C0220615 | Adult Acute Myeloblastic Leukemia | 1 | BeFree |
umls:C0346255 | Oncocytoma, renal | 1 | BeFree |
umls:C0949541 | Hurthle Cell Tumor | 1 | BeFree |
umls:C1266042 | Chromophobe Renal Cell Carcinoma | 1 | BeFree |
umls:C1378050 | Oncocytic Neoplasm | 1 | BeFree |