TissGeneSummary for ADAM29 |
Gene summary |
Basic gene information | Gene symbol | ADAM29 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM29 | |
BioGPS: 101928551 | ||
Pathway | NCI Pathway Interaction Database: ADAM29 | |
KEGG: ADAM29 | ||
REACTOME: ADAM29 | ||
Pathway Commons: ADAM29 | ||
Context | iHOP: ADAM29 | |
ligand binding site mutation search in PubMed: ADAM29 | ||
UCL Cancer Institute: ADAM29 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADAM29 | ||
Description by TissGene annotations | Cancer gene Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAM29 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.424730661 | 0.293448649 | -1.71817931 | 3.76E-14 | 3.47E-13 |
LUSC | -1.770990262 | 0.067270522 | -1.838260784 | 1.88E-15 | 1.23E-14 |
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TissGene-miRNA for ADAM29 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAM29 |
TissGeneSNV for ADAM29 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S327L | SKCM | 2 |
p.G125E | SKCM | 2 |
p.V205I | GBM | 2 |
p.G408E | SKCM | 2 |
p.D463Y | LUAD | 2 |
p.R399C | UCEC | 2 |
p.E495K | SKCM | 2 |
p.P36S | SKCM | 2 |
p.T746M | COAD | 2 |
p.R174Q | SKCM | 2 |
p.S115F | SKCM | 2 |
p.N276D | LUAD | 1 |
p.P138L | SKCM | 1 |
p.R724L | ESCA | 1 |
p.G192S | SKCM | 1 |
p.G60S | OV | 1 |
p.L10F | SKCM | 1 |
p.P563S | SKCM | 1 |
p.E249K | SKCM | 1 |
p.G104S | SKCM | 1 |
p.S547L | SKCM | 1 |
p.R381K | SKCM | 1 |
p.Q749H | UCEC | 1 |
p.R311H | GBM | 1 |
p.P49S | BLCA | 1 |
p.P703R | LIHC | 1 |
p.E461K | SKCM | 1 |
p.D548E | ESCA | 1 |
p.Q21H | THYM | 1 |
p.V710F | KIRC | 1 |
p.R38M | LUAD | 1 |
p.G605E | SKCM | 1 |
p.D131E | LUAD | 1 |
p.H572N | HNSC | 1 |
p.P279L | SKCM | 1 |
p.W194X | SKCM | 1 |
p.K537N | UCEC | 1 |
p.G165R | PRAD | 1 |
p.R724X | KIRC | 1 |
p.P486L | LGG | 1 |
p.E503K | SKCM | 1 |
p.S286L | SKCM | 1 |
p.K365E | OV | 1 |
p.C625F | STAD | 1 |
p.D373E | ESCA | 1 |
p.E201K | SKCM | 1 |
p.E135K | SKCM | 1 |
p.R348H | GBM | 1 |
p.H617Y | SKCM | 1 |
p.Q803X | COAD | 1 |
p.E410* | THYM | 1 |
p.G121R | SKCM | 1 |
p.F576L | HNSC | 1 |
p.V205I | THYM | 1 |
p.V397A | BLCA | 1 |
p.M340I | SKCM | 1 |
p.S115F | BLCA | 1 |
p.G372S | SKCM | 1 |
p.D548Y | STAD | 1 |
p.S370I | ESCA | 1 |
p.S160L | SKCM | 1 |
p.E518D | LUAD | 1 |
p.V205I | COAD | 1 |
p.P25S | SKCM | 1 |
p.P734T | PRAD | 1 |
p.E23* | HNSC | 1 |
p.Q742* | BLCA | 1 |
p.H333N | LUSC | 1 |
p.P725T | LUAD | 1 |
p.G121W | BLCA | 1 |
p.R771Q | CESC | 1 |
p.G535V | UCEC | 1 |
p.H617L | SKCM | 1 |
p.S265F | SKCM | 1 |
p.F479V | ESCA | 1 |
p.T118I | SKCM | 1 |
p.P31L | BRCA | 1 |
p.H103Y | SKCM | 1 |
p.R771W | COAD | 1 |
p.C270Y | STAD | 1 |
p.L441F | SKCM | 1 |
p.S547L | BLCA | 1 |
p.C173* | GBM | 1 |
p.G359S | SKCM | 1 |
p.G125R | SKCM | 1 |
p.D500Y | LUAD | 1 |
p.H333Y | THYM | 1 |
p.V227F | HNSC | 1 |
p.Q86H | ESCA | 1 |
p.P94Q | SKCM | 1 |
p.D207E | UCEC | 1 |
p.P762S | SKCM | 1 |
p.P465S | LUAD | 1 |
p.N525K | HNSC | 1 |
p.E719K | SKCM | 1 |
p.G657V | STAD | 1 |
p.D709N | LIHC | 1 |
p.G108E | SKCM | 1 |
p.G414E | SKCM | 1 |
p.D477G | PRAD | 1 |
p.Q803K | OV | 1 |
p.K720T | STAD | 1 |
p.R696Q | COAD | 1 |
p.C313R | PRAD | 1 |
p.N320S | SKCM | 1 |
p.E482A | UCEC | 1 |
p.P703S | SKCM | 1 |
p.Q789* | BLCA | 1 |
p.T746M | DLBC | 1 |
p.S626* | SKCM | 1 |
p.H8L | LUAD | 1 |
p.S739F | SKCM | 1 |
p.F145I | HNSC | 1 |
p.W251L | LUAD | 1 |
p.R530P | LUSC | 1 |
p.T322I | SKCM | 1 |
p.K242N | UCEC | 1 |
p.H568Y | SKCM | 1 |
p.T519N | LUAD | 1 |
p.Q86* | CESC | 1 |
p.I394L | COAD | 1 |
p.P94S | PRAD | 1 |
p.G104D | SKCM | 1 |
p.H787Q | SKCM | 1 |
p.Q778* | BLCA | 1 |
p.L464P | SKCM | 1 |
p.T388R | BRCA | 1 |
p.T818M | BLCA | 1 |
p.P79L | SKCM | 1 |
p.V238L | GBM | 1 |
p.R575C | SKCM | 1 |
p.R724* | KIRC | 1 |
p.G121E | HNSC | 1 |
p.P31L | KIRC | 1 |
p.G665D | BLCA | 1 |
p.G484R | SKCM | 1 |
p.D237E | SKCM | 1 |
p.E603* | LUAD | 1 |
p.Y54N | HNSC | 1 |
p.S811F | SKCM | 1 |
p.M319I | SKCM | 1 |
p.P743S | SKCM | 1 |
p.L225I | BRCA | 1 |
p.V763L | GBM | 1 |
p.R399C | COAD | 1 |
p.Q794H | PAAD | 1 |
p.P31L | GBM | 1 |
p.N652K | LUAD | 1 |
p.Q21K | BLCA | 1 |
p.D594N | HNSC | 1 |
p.I202V | COAD | 1 |
p.D109V | ESCA | 1 |
p.P48T | PRAD | 1 |
p.Q731K | LIHC | 1 |
p.P792T | LIHC | 1 |
p.G296R | SKCM | 1 |
p.D600Y | UCEC | 1 |
p.G659R | SKCM | 1 |
p.S160L | BLCA | 1 |
p.S234F | SKCM | 1 |
p.A513T | GBM | 1 |
p.S802F | BLCA | 1 |
p.R696Q | SKCM | 1 |
p.R216M | UCEC | 1 |
p.L73W | LUAD | 1 |
p.G440E | SKCM | 1 |
p.N460I | LUAD | 1 |
p.E557D | UCEC | 1 |
p.M356I | HNSC | 1 |
p.P423S | SKCM | 1 |
p.D261N | SKCM | 1 |
p.P747L | SKCM | 1 |
p.Q803H | BRCA | 1 |
p.K254T | UCEC | 1 |
p.H63Y | BRCA | 1 |
p.G121E | SKCM | 1 |
p.R530C | SKCM | 1 |
p.P352H | LUAD | 1 |
p.G335V | OV | 1 |
p.L524F | ESCA | 1 |
p.V34L | BRCA | 1 |
p.P780S | SKCM | 1 |
p.E380D | UCEC | 1 |
p.P792R | LUSC | 1 |
p.P762A | BLCA | 1 |
p.L690F | HNSC | 1 |
p.V205I | PAAD | 1 |
p.C487Y | STAD | 1 |
p.E275* | PRAD | 1 |
p.R213C | BRCA | 1 |
p.I355L | PAAD | 1 |
p.G293E | SKCM | 1 |
p.D607Y | UCEC | 1 |
p.G535D | STAD | 1 |
p.Q185E | BLCA | 1 |
p.G452R | SKCM | 1 |
p.S757F | SKCM | 1 |
p.S142F | SKCM | 1 |
p.Q21P | LIHC | 1 |
p.G301* | UCEC | 1 |
p.V763M | LUSC | 1 |
p.R213C | COAD | 1 |
p.Q185E | LUSC | 1 |
p.G659V | PAAD | 1 |
p.E406D | LUSC | 1 |
p.T818M | STAD | 1 |
p.F303L | LIHC | 1 |
p.Q803* | LUSC | 1 |
p.S350L | SKCM | 1 |
p.Q776* | BLCA | 1 |
p.S547* | BRCA | 1 |
p.Q758* | SKCM | 1 |
p.I579R | LUAD | 1 |
p.R174Q | UCEC | 1 |
p.R348H | LIHC | 1 |
p.V114D | SKCM | 1 |
p.S451* | BLCA | 1 |
p.G165E | SKCM | 1 |
p.W194* | SKCM | 1 |
p.N98Y | LUSC | 1 |
p.R174Q | READ | 1 |
p.K271Q | LIHC | 1 |
p.C581F | LUSC | 1 |
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TissGeneCNV for ADAM29 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAM29 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF171931 | ADAM29-PEG10 | chr4:175898962 | chr7:94295024 |
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TissGeneNet for ADAM29 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAM29 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAM29 |
TissGeneDrug for ADAM29 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAM29 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023434 | Chronic Lymphocytic Leukemia | 3 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree,GWASCAT |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0520679 | Sleep Apnea, Obstructive | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |