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| TissGeneSummary for PRG4 |
 Gene summary |
| Basic gene information | Gene symbol | PRG4 |
| Gene name | proteoglycan 4 | |
| Synonyms | CACP|HAPO|JCAP|MSF|SZP | |
| Cytomap | UCSC genome browser: 1q25-q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001127708.1, NM_001127709.1,NM_001127710.1,NM_005807.3, | |
| Description | articular superficial zone proteinlubricinmegakaryocyte stimulating factorsuperficial zone proteoglycan | |
| Modification date | 20141220 | |
| dbXrefs | MIM : 604283 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000116690 | ||
| HPRD : 05047 | ||
| Vega : OTTHUMG00000035574 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRG4 | |
| BioGPS: 10216 | ||
| Pathway | NCI Pathway Interaction Database: PRG4 | |
| KEGG: PRG4 | ||
| REACTOME: PRG4 | ||
| Pathway Commons: PRG4 | ||
| Context | iHOP: PRG4 | |
| ligand binding site mutation search in PubMed: PRG4 | ||
| UCL Cancer Institute: PRG4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSARC | |
| Reference showing the relevant tissue of PRG4 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PRG4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 6.726107323 | 9.338847323 | -2.61274 | 7.93E-07 | 4.33E-06 |
| BRCA | 1.346141323 | 3.740052726 | -2.393911404 | 6.53E-10 | 2.36E-09 |
| LUAD | 1.914689599 | 5.332237874 | -3.417548276 | 1.97E-14 | 1.90E-13 |
| LUSC | -0.074504756 | 5.325054068 | -5.399558824 | 8.39E-21 | 1.10E-19 |
| HNSC | -0.387978445 | 1.692247137 | -2.080225581 | 0.000353 | 0.001369397 |
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| TissGene-miRNA for PRG4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PRG4 |
| TissGeneSNV for PRG4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T471P | PAAD | 3 |
| p.T417P | PRAD | 3 |
| p.T572A | ESCA | 3 |
| p.S427P | UVM | 3 |
| p.T471P | CHOL | 2 |
| p.P464T | UCEC | 2 |
| p.E833K | SKCM | 2 |
| p.E740K | SKCM | 2 |
| p.P656L | STAD | 2 |
| p.E473K | UCEC | 2 |
| p.A66V | COAD | 2 |
| p.T417P | LUAD | 2 |
| p.P440T | THYM | 2 |
| p.S427P | UCEC | 2 |
| p.K204N | KIRC | 2 |
| p.G1206E | SKCM | 2 |
| p.G780E | KIRC | 2 |
| p.T401P | LUAD | 2 |
| p.T597P | LGG | 2 |
| p.T401P | PCPG | 2 |
| p.P661L | SKCM | 1 |
| p.T542P | ESCA | 1 |
| p.D109Y | COAD | 1 |
| p.T572A | HNSC | 1 |
| p.E221D | COAD | 1 |
| p.P568L | SKCM | 1 |
| p.T752I | STAD | 1 |
| p.E615K | LUAD | 1 |
| p.K504N | HNSC | 1 |
| p.E434K | SKCM | 1 |
| p.T460A | LGG | 1 |
| p.G809E | PCPG | 1 |
| p.A561S | KIRC | 1 |
| p.A649T | UCEC | 1 |
| p.K143N | UCEC | 1 |
| p.T471P | KIRC | 1 |
| p.A942G | STAD | 1 |
| p.P581T | LUAD | 1 |
| p.C64S | SKCM | 1 |
| p.P953S | SKCM | 1 |
| p.K506Q | SKCM | 1 |
| p.Y9S | BRCA | 1 |
| p.T1351A | STAD | 1 |
| p.K1029I | UCEC | 1 |
| p.S167C | HNSC | 1 |
| p.E801K | SKCM | 1 |
| p.T978I | LGG | 1 |
| p.P260S | STAD | 1 |
| p.E256K | SKCM | 1 |
| p.T401P | SKCM | 1 |
| p.E857K | READ | 1 |
| p.S427P | PCPG | 1 |
| p.K1026N | STAD | 1 |
| p.E559K | HNSC | 1 |
| p.P98A | LUAD | 1 |
| p.G1201E | SKCM | 1 |
| p.A125S | READ | 1 |
| p.P440T | BLCA | 1 |
| p.P396H | UCEC | 1 |
| p.R1391S | SARC | 1 |
| p.D923Y | UCEC | 1 |
| p.Y53S | PAAD | 1 |
| p.D923N | PAAD | 1 |
| p.Q164H | SKCM | 1 |
| p.S553A | STAD | 1 |
| p.E1187K | SKCM | 1 |
| p.Y1169H | PRAD | 1 |
| p.T557P | BRCA | 1 |
| p.T527S | LUSC | 1 |
| p.E288* | UCEC | 1 |
| p.T460A | PCPG | 1 |
| p.S123P | LGG | 1 |
| p.L14M | LUAD | 1 |
| p.T471P | PCPG | 1 |
| p.R1010I | UCEC | 1 |
| p.P448L | SKCM | 1 |
| p.L344V | ESCA | 1 |
| p.E403K | UCEC | 1 |
| p.Q164L | SKCM | 1 |
| p.T1390A | STAD | 1 |
| p.P482L | PRAD | 1 |
| p.E76K | BLCA | 1 |
| p.T471P | STAD | 1 |
| p.G1241* | LUAD | 1 |
| p.T572A | LUAD | 1 |
| p.P217Q | CESC | 1 |
| p.P666T | LUSC | 1 |
| p.P549T | SKCM | 1 |
| p.P464T | KIRC | 1 |
| p.E281G | LIHC | 1 |
| p.P1046S | SKCM | 1 |
| p.D781N | SKCM | 1 |
| p.G223A | HNSC | 1 |
| p.P605A | SKCM | 1 |
| p.E537D | READ | 1 |
| p.R1303H | UCEC | 1 |
| p.P164T | COAD | 1 |
| p.T511P | HNSC | 1 |
| p.G711E | SARC | 1 |
| p.P836R | LUAD | 1 |
| p.P1052R | LUSC | 1 |
| p.P546S | LGG | 1 |
| p.P459H | LUAD | 1 |
| p.Y1367N | LIHC | 1 |
| p.E466K | CESC | 1 |
| p.T460S | HNSC | 1 |
| p.P698A | SKCM | 1 |
| p.E341K | SKCM | 1 |
| p.L648P | STAD | 1 |
| p.E591G | UCEC | 1 |
| p.R192G | LUAD | 1 |
| p.P818H | LUAD | 1 |
| p.P661T | LUAD | 1 |
| p.T194I | READ | 1 |
| p.P453S | LGG | 1 |
| p.D1222N | CESC | 1 |
| p.C84S | LUAD | 1 |
| p.S249F | CESC | 1 |
| p.P508H | LUSC | 1 |
| p.A66V | SARC | 1 |
| p.P363H | LUSC | 1 |
| p.T510A | STAD | 1 |
| p.T1156A | UCEC | 1 |
| p.P533L | READ | 1 |
| p.P1229H | PRAD | 1 |
| p.T401P | UCEC | 1 |
| p.A66T | LUAD | 1 |
| p.E193* | STAD | 1 |
| p.E193X | STAD | 1 |
| p.T534P | BLCA | 1 |
| p.R82K | LUSC | 1 |
| p.T1115S | READ | 1 |
| p.T417P | BLCA | 1 |
| p.P520R | SKCM | 1 |
| p.P522T | LUAD | 1 |
| p.G1009R | SKCM | 1 |
| p.T945A | CHOL | 1 |
| p.E559K | GBM | 1 |
| p.K205R | ESCA | 1 |
| p.E950K | UCEC | 1 |
| p.G1294E | SKCM | 1 |
| p.A1164E | THYM | 1 |
| p.P928T | LUSC | 1 |
| p.T781P | PAAD | 1 |
| p.K205N | UCS | 1 |
| p.K1036T | UCEC | 1 |
| p.K280E | SKCM | 1 |
| p.K91N | UCEC | 1 |
| p.E152X | ESCA | 1 |
| p.I1308K | PAAD | 1 |
| p.R1218H | GBM | 1 |
| p.P378T | KIRC | 1 |
| p.K186R | SKCM | 1 |
| p.A405S | THYM | 1 |
| p.K472N | UCEC | 1 |
| p.K426N | UCEC | 1 |
| p.E895K | SKCM | 1 |
| p.E450K | SKCM | 1 |
| p.T715A | LIHC | 1 |
| p.D99Y | ESCA | 1 |
| p.K558N | UCEC | 1 |
| p.A918S | COAD | 1 |
| p.G1102R | SKCM | 1 |
| p.R1218H | LGG | 1 |
| p.F103L | READ | 1 |
| p.E152Q | BLCA | 1 |
| p.R960C | COAD | 1 |
| p.T417P | THCA | 1 |
| p.R207I | UCEC | 1 |
| p.T401P | KIRC | 1 |
| p.G1206E | SARC | 1 |
| p.K726N | UCEC | 1 |
| p.A405S | ESCA | 1 |
| p.R1042T | BLCA | 1 |
| p.T401P | HNSC | 1 |
| p.T460A | LUSC | 1 |
| p.D99N | UCEC | 1 |
| p.E349K | SKCM | 1 |
| p.G711V | LUSC | 1 |
| p.E380* | HNSC | 1 |
| p.P110A | LUAD | 1 |
| p.G780E | PAAD | 1 |
| p.P474L | PRAD | 1 |
| p.G1067E | SKCM | 1 |
| p.T597P | STAD | 1 |
| p.T704P | DLBC | 1 |
| p.T572A | THCA | 1 |
| p.G1132D | ESCA | 1 |
| p.K465E | HNSC | 1 |
| p.Y1169F | KIRC | 1 |
| p.T532S | LUSC | 1 |
| p.E630K | STAD | 1 |
| p.E655G | STAD | 1 |
| p.T401P | LGG | 1 |
| p.T1051I | LUSC | 1 |
| p.T597P | LUAD | 1 |
| p.D41Y | UCEC | 1 |
| p.A633T | LUSC | 1 |
| p.K210N | UCEC | 1 |
| p.P487T | UCEC | 1 |
| p.L1157* | KIRC | 1 |
| p.P613R | SKCM | 1 |
| p.T564A | COAD | 1 |
| p.T572A | PCPG | 1 |
| p.D874N | SKCM | 1 |
| p.F78I | BLCA | 1 |
| p.A389T | LUAD | 1 |
| p.E79K | COAD | 1 |
| p.K817T | UCEC | 1 |
| p.T807N | LUAD | 1 |
| p.T932I | STAD | 1 |
| p.D917H | LUAD | 1 |
| p.A486T | LGG | 1 |
| p.L1157X | KIRC | 1 |
| p.S881F | CESC | 1 |
| p.T597P | PRAD | 1 |
| p.K211Q | LIHC | 1 |
| p.K1280R | LIHC | 1 |
| p.G225* | UCEC | 1 |
| p.E349G | KIRC | 1 |
| p.E615K | SKCM | 1 |
| p.A672V | BLCA | 1 |
| p.A1182T | UCEC | 1 |
| p.P873H | LUAD | 1 |
| p.S422A | LGG | 1 |
| p.K599Q | SKCM | 1 |
| p.K143Q | PAAD | 1 |
| p.K142R | SKCM | 1 |
| p.T425P | HNSC | 1 |
| p.G780E | HNSC | 1 |
| p.G756R | SKCM | 1 |
| p.E879G | ESCA | 1 |
| p.S23X | COAD | 1 |
| p.T401P | OV | 1 |
| p.A31V | STAD | 1 |
| p.E272X | READ | 1 |
| p.P789H | STAD | 1 |
| p.T625M | TGCT | 1 |
| p.R1360I | THYM | 1 |
| p.I1068T | LUAD | 1 |
| p.R1218L | THYM | 1 |
| p.A665T | SKCM | 1 |
| p.P754R | HNSC | 1 |
| p.R1053L | LUAD | 1 |
| p.R1073Q | COAD | 1 |
| p.K138T | READ | 1 |
| p.P983S | CESC | 1 |
| p.A750T | LUAD | 1 |
| p.T635I | STAD | 1 |
| p.G1113E | SKCM | 1 |
| p.E79K | SKCM | 1 |
| p.K232* | LUAD | 1 |
| p.R1284K | BLCA | 1 |
| p.T712S | THYM | 1 |
| p.S515A | STAD | 1 |
| p.Y9* | LUAD | 1 |
| p.P440T | ESCA | 1 |
| p.G1160E | SKCM | 1 |
| p.M1040T | BLCA | 1 |
| p.E1094K | SKCM | 1 |
| p.T460A | PRAD | 1 |
| p.K488N | UCEC | 1 |
| p.R33K | BLCA | 1 |
| p.D923E | UCEC | 1 |
| p.T572A | THYM | 1 |
| p.P519L | LUAD | 1 |
| p.K1263N | BLCA | 1 |
| p.P778L | LUAD | 1 |
| p.N675S | STAD | 1 |
| p.T907N | LUSC | 1 |
| p.R207S | STAD | 1 |
| p.T346A | SKCM | 1 |
| p.K117N | CESC | 1 |
| p.P378T | LUAD | 1 |
| p.E940Q | BLCA | 1 |
| p.P461L | PRAD | 1 |
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| TissGeneCNV for PRG4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PRG4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PRG4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| COAD (tumor) | COAD (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| KICH (tumor) | KICH (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| STAD (tumor) | STAD (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| THCA (tumor) | THCA (normal) |
| PRG4, GRB2 (tumor) | PRG4, GRB2 (normal) |
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| Top |
| TissGeneProg for PRG4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for PRG4 |
| TissGeneDrug for PRG4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PRG4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1859690 | CAMPTODACTYLY-ARTHROPATHY-COXA VARA-PERICARDITIS SYNDROME | 7 | BeFree,CLINVAR,CTD_human,ORPHANET |
| umls:C0031046 | Pericarditis | 6 | BeFree,CTD_human |
| umls:C0221369 | Acquired Camptodactyly | 4 | BeFree |
| umls:C0685409 | Congenital Camptodactyly | 4 | BeFree |
| umls:C0023418 | leukemia | 3 | BeFree |
| umls:C0022408 | Arthropathy | 2 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0009917 | Contracture | 1 | CTD_human |
| umls:C0020507 | Hyperplasia | 1 | CTD_human |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0033587 | Prosthesis Loosening | 1 | BeFree |
| umls:C0039516 | Tennis Elbow | 1 | LHGDN |
| umls:C0409959 | Osteoarthritis, Knee | 1 | LHGDN |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0683381 | inflammatory joint disease | 1 | BeFree |
| umls:C1510420 | Cavitation | 1 | BeFree |
| umls:C2825306 | Treatment related leukaemia | 1 | BeFree |
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