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| TissGeneSummary for GLYAT |
 Gene summary |
| Basic gene information | Gene symbol | GLYAT |
| Gene name | glycine-N-acyltransferase | |
| Synonyms | ACGNAT|CAT|GAT | |
| Cytomap | UCSC genome browser: 11q12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005838.3, NM_201648.2, | |
| Description | AAcHRP-1(CLP)acyl-CoA:glycine N-acyltransferasearalkyl acyl-CoA N-acyltransferasearalkyl acyl-CoA:amino acid N-acyltransferasearalkyl-CoA N-acyltransferasebenzoyl-coenzyme A:glycine N-acyltransferaseglycine N-acyltransferaseglycine N-benzoyltransf | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607424 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000149124 | ||
| HPRD : 07603 | ||
| Vega : OTTHUMG00000167429 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GLYAT | |
| BioGPS: 10249 | ||
| Pathway | NCI Pathway Interaction Database: GLYAT | |
| KEGG: GLYAT | ||
| REACTOME: GLYAT | ||
| Pathway Commons: GLYAT | ||
| Context | iHOP: GLYAT | |
| ligand binding site mutation search in PubMed: GLYAT | ||
| UCL Cancer Institute: GLYAT | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of GLYAT | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for GLYAT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.915389038 | 7.829766962 | -8.745156 | 9.61E-17 | 3.21E-15 |
| LIHC | 7.044454962 | 10.76834696 | -3.723892 | 1.36E-09 | 1.45E-08 |
| BRCA | -0.083237705 | 5.455918436 | -5.53915614 | 2.36E-45 | 1.06E-43 |
| KIRP | 6.827147712 | 9.094478962 | -2.26733125 | 0.00244 | 0.006125957 |
| Top |
| TissGene-miRNA for GLYAT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GLYAT |
| TissGeneSNV for GLYAT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S17F | SKCM | 3 |
| p.G38E | SKCM | 2 |
| p.W291* | SKCM | 2 |
| p.R199C | LGG | 2 |
| p.W219* | SKCM | 2 |
| p.D220N | LIHC | 1 |
| p.W288X | SKCM | 1 |
| p.P83L | SKCM | 1 |
| p.W288* | SKCM | 1 |
| p.L90F | SARC | 1 |
| p.W219C | LUAD | 1 |
| p.G38* | LUAD | 1 |
| p.P23Q | LUAD | 1 |
| p.H186N | LUAD | 1 |
| p.S268N | SKCM | 1 |
| p.Q61H | KIRP | 1 |
| p.P283L | SKCM | 1 |
| p.E142K | SKCM | 1 |
| p.D266Y | LUAD | 1 |
| p.L234S | UCEC | 1 |
| p.M228I | SKCM | 1 |
| p.K161N | STAD | 1 |
| p.E213K | BLCA | 1 |
| p.I78M | HNSC | 1 |
| p.L210M | KIRP | 1 |
| p.H101N | READ | 1 |
| p.W291X | SKCM | 1 |
| p.L221I | ESCA | 1 |
| p.R131H | STAD | 1 |
| p.S107L | SKCM | 1 |
| p.E15* | LUAD | 1 |
| p.S172F | SKCM | 1 |
| p.R131C | GBM | 1 |
| p.T75I | HNSC | 1 |
| p.P145H | MESO | 1 |
| p.Y134H | LUAD | 1 |
| p.S25F | HNSC | 1 |
| p.L102* | LUAD | 1 |
| p.L18S | SKCM | 1 |
| p.T129A | SKCM | 1 |
| p.P235L | STAD | 1 |
| p.E236K | SKCM | 1 |
| p.S263F | STAD | 1 |
| p.L234F | BRCA | 1 |
| p.E138K | BLCA | 1 |
| p.T225I | SKCM | 1 |
| p.W219X | SKCM | 1 |
| p.L133I | BLCA | 1 |
| p.R131C | LUAD | 1 |
| p.L118F | SKCM | 1 |
| p.L118I | READ | 1 |
| p.Y277* | PAAD | 1 |
| p.P60S | LUAD | 1 |
| p.G30E | SKCM | 1 |
| p.S92L | SKCM | 1 |
| p.L221V | LUAD | 1 |
| p.E166D | UCEC | 1 |
| p.W291C | HNSC | 1 |
| p.I96N | LUAD | 1 |
| p.L234F | LIHC | 1 |
| p.R199C | COAD | 1 |
| p.L133F | HNSC | 1 |
| p.L118F | UCS | 1 |
| p.Q61K | LUAD | 1 |
| p.L90P | STAD | 1 |
| p.T31N | LUAD | 1 |
| Top |
| TissGeneCNV for GLYAT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for GLYAT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for GLYAT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (tumor) | GLYAT, HNF4A, PTN, GPRASP1, VOPP1 (normal) |
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| Top |
| TissGeneProg for GLYAT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for GLYAT |
| TissGeneDrug for GLYAT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GLYAT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019693 | HIV Infections | 23 | BeFree |
| umls:C2239176 | Liver carcinoma | 19 | BeFree |
| umls:C0023903 | Liver neoplasms | 15 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 14 | BeFree |
| umls:C0678222 | Breast Carcinoma | 14 | BeFree |
| umls:C0027819 | Neuroblastoma | 5 | BeFree |
| umls:C0039730 | Thalassemia | 5 | BeFree |
| umls:C0600139 | Prostate carcinoma | 5 | BeFree |
| umls:C0700095 | Central neuroblastoma | 5 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 5 | BeFree |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree |
| umls:C0004096 | Asthma | 4 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree |
| umls:C0206624 | Hepatoblastoma | 4 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 4 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree |
| umls:C0752120 | Spinocerebellar Ataxia Type 1 | 4 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
| umls:C0024299 | Lymphoma | 3 | BeFree |
| umls:C0032002 | Pituitary Diseases | 3 | BeFree |
| umls:C0042900 | Vitiligo | 3 | BeFree |
| umls:C0043346 | Xeroderma Pigmentosum | 3 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree |
| umls:C0271980 | beta^0^ Thalassemia | 3 | BeFree |
| umls:C0302592 | Cervix carcinoma | 3 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0684249 | Carcinoma of lung | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0008497 | Choriocarcinoma | 2 | BeFree |
| umls:C0009207 | Cockayne Syndrome | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
| umls:C0032461 | Polycythemia | 2 | BeFree |
| umls:C0162872 | Aortic Aneurysm, Thoracic | 2 | BeFree |
| umls:C0238461 | Anaplastic thyroid carcinoma | 2 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 2 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 2 | BeFree |
| umls:C1527405 | Erythrocytosis | 2 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0002894 | Refractory anaemia with excess blasts | 1 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0004763 | Barrett Esophagus | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007130 | Mucinous Adenocarcinoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0008384 | Cholesterol Ester Storage Disease | 1 | BeFree |
| umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
| umls:C0010495 | Cutis Laxa | 1 | BeFree |
| umls:C0011389 | Dental Plaque | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0016667 | Fragile X Syndrome | 1 | BeFree |
| umls:C0018784 | Sensorineural Hearing Loss (disorder) | 1 | BeFree |
| umls:C0018790 | Cardiac Arrest | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0019202 | Hepatolenticular Degeneration | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0021364 | Male infertility | 1 | BeFree |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0021670 | insulinoma | 1 | BeFree |
| umls:C0022610 | Kernicterus | 1 | BeFree |
| umls:C0023269 | leiomyosarcoma | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023524 | Leukoencephalopathy, Progressive Multifocal | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | BeFree |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0024534 | Malaria, Cerebral | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025007 | Measles | 1 | BeFree |
| umls:C0025362 | Mental Retardation | 1 | BeFree |
| umls:C0026499 | Monosomy | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027708 | Nephroblastoma | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0031511 | Pheochromocytoma | 1 | BeFree |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0032131 | Plasmacytoma | 1 | BeFree |
| umls:C0033575 | Prostatic Diseases | 1 | BeFree |
| umls:C0037889 | Hereditary spherocytosis | 1 | BeFree |
| umls:C0038826 | Superinfection | 1 | BeFree |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0079474 | Hallopeau-Siemens Disease | 1 | BeFree |
| umls:C0085179 | Eosinophilia-Myalgia Syndrome | 1 | BeFree |
| umls:C0087012 | Ataxia, Spinocerebellar | 1 | BeFree |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0175754 | Agenesis of corpus callosum | 1 | BeFree |
| umls:C0206659 | Embryonal Carcinoma | 1 | BeFree |
| umls:C0206663 | Neuroectodermal Tumor, Primitive | 1 | BeFree |
| umls:C0206664 | Teratocarcinoma | 1 | BeFree |
| umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
| umls:C0234133 | Extrapyramidal sign | 1 | BeFree |
| umls:C0235031 | Neurologic Symptoms | 1 | BeFree |
| umls:C0235946 | Cerebral atrophy | 1 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
| umls:C0266929 | Chronic Periodontitis | 1 | BeFree |
| umls:C0268483 | Tyrosinemias | 1 | BeFree |
| umls:C0268540 | HHH syndrome | 1 | BeFree |
| umls:C0270814 | Spastic syndrome | 1 | BeFree |
| umls:C0272322 | Severe hereditary factor VIII deficiency disease | 1 | BeFree |
| umls:C0278837 | Stage IV Prostate Carcinoma | 1 | BeFree |
| umls:C0279980 | Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 1 | BeFree |
| umls:C0342471 | 3 beta-Hydroxysteroid dehydrogenase deficiency | 1 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 1 | BeFree |
| umls:C0345907 | Angiosarcoma of liver | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0555232 | pseudohermaphrodite (non-specific) | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0684337 | Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0872054 | latent infection | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1176475 | Ductal Carcinoma | 1 | BeFree |
| umls:C1258104 | Diffuse Scleroderma | 1 | BeFree |
| umls:C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1527349 | Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | BeFree |
| umls:C2674218 | SPHEROCYTOSIS, TYPE 1 (disorder) | 1 | BeFree |
| umls:C3146264 | Stage IV Prostate Cancer AJCC v7 | 1 | BeFree |
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