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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CDKN3
check button Gene summary
Basic gene informationGene symbolCDKN3
Gene namecyclin-dependent kinase inhibitor 3
SynonymsCDI1|CIP2|KAP|KAP1
CytomapUCSC genome browser: 14q22
Type of geneprotein-coding
RefGenesNM_001130851.1,
NM_005192.3,
DescriptionCDK2-associated dual specificity phosphataseCDK2-associated dual-specificity phosphataseCdk-associated protein phosphatasecyclin-dependent kinase interacting protein 2cyclin-dependent kinase interactor 1cyclin-dependent kinase-interacting protein 2k
Modification date20141207
dbXrefs MIM : 123832
HGNC : HGNC
Ensembl : ENSG00000100526
HPRD : 00450
Vega : OTTHUMG00000140302
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CDKN3
BioGPS: 1033
PathwayNCI Pathway Interaction Database: CDKN3
KEGG: CDKN3
REACTOME: CDKN3
Pathway Commons: CDKN3
ContextiHOP: CDKN3
ligand binding site mutation search in PubMed: CDKN3
UCL Cancer Institute: CDKN3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of CDKN3
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007050cell cycle arrest8242750
GO:0035335peptidyl-tyrosine dephosphorylation8242750
GO:0007050cell cycle arrest8242750
GO:0035335peptidyl-tyrosine dephosphorylation8242750


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TissGeneExp for CDKN3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC2.5765259851.2071190091.3694069773.83E-118.70E-10
KIRP-0.44205134-2.8764232152.4343718757.99E-107.59E-09
KIRC-0.381668007-2.3970777292.0154097228.31E-227.36E-21
KICH-0.44858434-2.455880342.0072962.15E-056.37E-05
LUSC2.51439817-1.2827939873.7971921576.13E-346.00E-32
PRAD-0.919155186-2.2603474941.3411923085.36E-085.41E-07
BRCA1.613555239-1.2523614282.8659166675.14E-525.27E-50
COAD2.8977928911.7467198141.1510730775.81E-073.42E-06
STAD2.6767767850.7622205351.914556251.28E-073.31E-06
LUAD1.327849522-1.6375884092.9654379316.14E-231.89E-21
LIHC1.45903766-2.511566343.9706042.99E-291.66E-26
ESCA2.249496387-0.4739308862.7234272735.34E-060.000899131
BLCA2.338902607-0.1592658142.4981684211.51E-050.000262363


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TissGene-miRNA for CDKN3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CDKN3
TissGeneSNV for CDKN3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Y141CPAAD1
p.T145ALUAD1
p.L189RSTAD1
p.D63HHNSC1
p.G142VBLCA1
p.L156ITGCT1
p.P49THNSC1
p.R172*LGG1
p.E17KLIHC1
p.I72TLIHC1
p.R132XLGG1
p.R193QUCEC1


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TissGeneCNV for CDKN3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CDKN3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNADB356803HSPA1A-CDKN3chr6:3079369chr14:54874845
Chimerdb3.0FusionScanPRADTCGA-V1-A8WS-01AECI1-CDKN3Out-of-Framechr16:2301316chr14:54868241
TCGAfusionPortalPRADABLCATCGA-FD-A3SS-01AGRN-CDKN3NAChr17:42430470Chr14:54877897
TCGAfusionPortalPRADALUADTCGA-86-A4D0-01ACDKN3-SFTA3Out-of-frameChr14:54868297Chr14:36960496


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TissGeneNet for CDKN3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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COAD (tumor)COAD (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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HNSC (tumor)HNSC (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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KICH (tumor)KICH (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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KIRC (tumor)KIRC (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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KIRP (tumor)KIRP (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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LIHC (tumor)LIHC (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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LUAD (tumor)LUAD (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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LUSC (tumor)LUSC (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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PRAD (tumor)PRAD (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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STAD (tumor)STAD (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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THCA (tumor)THCA (normal)
CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (tumor)CDKN3, NCOA3, CDK1, EGR1, CDK2, CEBPA, CDK3, CDC25A, MS4A3 (normal)
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TissGeneProg for CDKN3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CDKN3
TissGeneDrug for CDKN3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CDKN3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast15BeFree
umls:C0678222Breast Carcinoma14BeFree
umls:C0025202melanoma13BeFree
umls:C0596263Carcinogenesis11BeFree
umls:C0023418leukemia9BeFree
umls:C2239176Liver carcinoma9BeFree,UNIPROT
umls:C0035335Retinoblastoma8BeFree
umls:C0019693HIV Infections7BeFree
umls:C0376358Malignant neoplasm of prostate7BeFree
umls:C0007847Malignant tumor of cervix6BeFree
umls:C0024623Malignant neoplasm of stomach6BeFree
umls:C0027627Neoplasm Metastasis6BeFree
umls:C0600139Prostate carcinoma6BeFree
umls:C0699791Stomach Carcinoma6BeFree
umls:C0007137Squamous cell carcinoma5BeFree
umls:C0023434Chronic Lymphocytic Leukemia5BeFree
umls:C0235974Pancreatic carcinoma5BeFree
umls:C0302592Cervix carcinoma5BeFree
umls:C0023903Liver neoplasms4BeFree
umls:C0024299Lymphoma4BeFree
umls:C0025267Multiple Endocrine Neoplasia Type 14BeFree
umls:C0027662Multiple Endocrine Neoplasia4BeFree
umls:C0029925Ovarian Carcinoma4BeFree
umls:C0346647Malignant neoplasm of pancreas4BeFree
umls:C0007131Non-Small Cell Lung Carcinoma3BeFree
umls:C0017636Glioblastoma3BeFree
umls:C0017638Glioma3BeFree
umls:C0032002Pituitary Diseases3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0262587Parathyroid Adenoma3BeFree
umls:C0339573Glaucoma, Primary Open Angle3BeFree
umls:C0677886Epithelial ovarian cancer3BeFree
umls:C1140680Malignant neoplasm of ovary3BeFree
umls:C1168401Squamous cell carcinoma of the head and neck3BeFree
umls:C1512409Hepatocarcinogenesis3BeFree
umls:C0004903Beckwith-Wiedemann Syndrome2BeFree
umls:C0007112Adenocarcinoma of prostate2BeFree
umls:C0007138Carcinoma, Transitional Cell2BeFree
umls:C0014175Endometriosis2BeFree
umls:C0014859Esophageal Neoplasms2BeFree
umls:C0023467Leukemia, Myelocytic, Acute2BeFree
umls:C0026764Multiple Myeloma2BeFree
umls:C0027708Nephroblastoma2BeFree
umls:C0027819Neuroblastoma2BeFree
umls:C0029463Osteosarcoma2BeFree
umls:C0032000Pituitary Adenoma2BeFree
umls:C0037286Skin Neoplasms2BeFree
umls:C0085669Acute leukemia2BeFree
umls:C0151779Cutaneous Melanoma2BeFree
umls:C0152018Esophageal carcinoma2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0206624Hepatoblastoma2BeFree
umls:C0279672Cervical Adenocarcinoma2BeFree
umls:C0280100Solid tumour2BeFree
umls:C0376545Hematologic Neoplasms2BeFree
umls:C0546837Malignant neoplasm of esophagus2BeFree
umls:C0585442Osteosarcoma of bone2BeFree
umls:C1261473Sarcoma2BeFree
umls:C1292753Primary Effusion Lymphoma2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0001430Adenoma1BeFree
umls:C0002940Aneurysm1BeFree
umls:C0003850Arteriosclerosis1BeFree
umls:C0003864Arthritis1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004096Asthma1BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0004135Ataxia Telangiectasia1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007114Malignant neoplasm of skin1BeFree
umls:C0007121Bronchogenic Carcinoma1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0011334Dental caries1GWASCAT
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0013264Muscular Dystrophy, Duchenne1BeFree
umls:C0013336Dwarfism1BeFree
umls:C0013403Dysplastic Nevus Syndrome1BeFree
umls:C0014742Erythema Multiforme1BeFree
umls:C0017601Glaucoma1BeFree
umls:C0017661IGA Glomerulonephritis1CTD_human
umls:C0019163Hepatitis B1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0020502Hyperparathyroidism1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0021841Intestinal Neoplasms1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0023492Leukemia, T-Cell1BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia1BeFree
umls:C0024301Lymphoma, Follicular1BeFree
umls:C0027019Myelomonocytic leukemia1BeFree
umls:C0027404Narcolepsy1GAD
umls:C0030354Papilloma1BeFree
umls:C0032019Pituitary Neoplasms1BeFree
umls:C0032131Plasmacytoma1BeFree
umls:C0032300Lobar Pneumonia1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0036220Kaposi Sarcoma1BeFree
umls:C0038356Stomach Neoplasms1BeFree
umls:C0039101synovial sarcoma1BeFree
umls:C0040100Thymoma1BeFree
umls:C0079744Diffuse Large B-Cell Lymphoma1BeFree
umls:C0079748Precursor cell lymphoblastic lymphoma1BeFree
umls:C0085400Neurofibrillary degeneration (morphologic abnormality)1BeFree
umls:C0155552Hearing Loss, Mixed Conductive-Sensorineural1BeFree
umls:C0155862Streptococcal pneumonia1BeFree
umls:C0162810Cicatrix, Hypertrophic1BeFree
umls:C0206659Embryonal Carcinoma1BeFree
umls:C0206663Neuroectodermal Tumor, Primitive1BeFree
umls:C0206708Cervical Intraepithelial Neoplasia1BeFree
umls:C0220636Malignant neoplasm of salivary gland1BeFree
umls:C0221273Juvenile polyp1BeFree
umls:C0238288Muscular Dystrophy, Facioscapulohumeral1BeFree
umls:C0238461Anaplastic thyroid carcinoma1BeFree
umls:C0238463Papillary thyroid carcinoma1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0279583T-cell childhood acute lymphoblastic leukemia1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0333186Restenosis1BeFree
umls:C0341439Chronic liver disease1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0345967Malignant mesothelioma1BeFree
umls:C0403592Chronic rejection of renal transplant1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0546817Fluid overload1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0812413Malignant Pleural Mesothelioma1BeFree
umls:C0858252Breast adenocarcinoma1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0948008Ischemic stroke1BeFree
umls:C0971858Arthritis, Collagen-Induced1BeFree
umls:C1168327High-Grade Prostatic Intraepithelial Neoplasia1BeFree
umls:C1336527Carcinoma of urinary bladder, superficial1BeFree
umls:C1511934Differentiating Neuroblastoma1BeFree
umls:C1516170Cancer Cell Growth1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree
umls:C2145472Urothelial Carcinoma1BeFree
umls:C2745900Promyelocytic leukemia1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree