TissGeneSummary for CDSN |
Gene summary |
Basic gene information | Gene symbol | CDSN |
Gene name | corneodesmosin | |
Synonyms | HTSS|HTSS1|HYPT2|PSS|PSS1|S | |
Cytomap | UCSC genome browser: 6p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001264.4, | |
Description | differentiated keratinocyte S protein | |
Modification date | 20141217 | |
dbXrefs | MIM : 602593 | |
HGNC : HGNC | ||
Ensembl : ENSG00000204539 | ||
HPRD : 03998 | ||
Vega : OTTHUMG00000031150 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDSN | |
BioGPS: 1041 | ||
Pathway | NCI Pathway Interaction Database: CDSN | |
KEGG: CDSN | ||
REACTOME: CDSN | ||
Pathway Commons: CDSN | ||
Context | iHOP: CDSN | |
ligand binding site mutation search in PubMed: CDSN | ||
UCL Cancer Institute: CDSN | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of CDSN | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016337 | single organismal cell-cell adhesion | 11739386 | GO:0016337 | single organismal cell-cell adhesion | 11739386 |
Top |
TissGeneExp for CDSN |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 2.374531068 | 0.141359881 | 2.233171186 | 5.68E-10 | 3.40E-09 |
BRCA | 1.6370797 | 0.450762156 | 1.186317544 | 1.27E-05 | 3.12E-05 |
KIRC | 0.063435328 | -1.994963283 | 2.058398611 | 3.00E-16 | 1.67E-15 |
KIRP | 0.219873176 | -1.892045574 | 2.11191875 | 2.62E-07 | 1.49E-06 |
LUSC | 0.985491619 | -0.056714263 | 1.042205882 | 0.00495 | 0.00828803 |
STAD | 0.662091926 | -0.374767449 | 1.036859375 | 0.00158 | 0.007576588 |
HNSC | 4.140495632 | 1.509002609 | 2.631493023 | 0.000824 | 0.002860169 |
Top |
TissGene-miRNA for CDSN |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CDSN |
TissGeneSNV for CDSN |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M18L | PCPG | 6 |
p.P309S | SKCM | 2 |
p.S338F | SKCM | 2 |
p.G335R | SKCM | 1 |
p.P282S | LUSC | 1 |
p.P485S | SKCM | 1 |
p.E297K | HNSC | 1 |
p.S245F | SKCM | 1 |
p.S164G | LIHC | 1 |
p.R47H | KIRP | 1 |
p.M18L | BRCA | 1 |
p.G185R | SKCM | 1 |
p.T374I | PAAD | 1 |
p.P231H | ESCA | 1 |
p.S288Y | READ | 1 |
p.P529S | SKCM | 1 |
p.C273Y | PRAD | 1 |
p.E524D | OV | 1 |
p.G429D | UCEC | 1 |
p.S463F | STAD | 1 |
p.M18V | STAD | 1 |
p.T385M | PAAD | 1 |
p.S220L | SKCM | 1 |
p.S198C | BLCA | 1 |
p.R216C | LUAD | 1 |
p.S437F | SKCM | 1 |
p.A103T | COAD | 1 |
p.G523E | SKCM | 1 |
p.Y296F | LIHC | 1 |
p.G208C | SKCM | 1 |
p.S152N | UCEC | 1 |
p.G109X | READ | 1 |
p.L278F | SKCM | 1 |
p.S305R | SARC | 1 |
p.P511L | SKCM | 1 |
p.H476Y | SKCM | 1 |
p.Q370X | SKCM | 1 |
p.G381E | SKCM | 1 |
p.V255M | SKCM | 1 |
p.P217S | SKCM | 1 |
p.Q370* | SKCM | 1 |
p.L56F | DLBC | 1 |
p.G373E | SKCM | 1 |
p.L176V | BLCA | 1 |
p.S401G | DLBC | 1 |
p.S3L | KIRC | 1 |
p.P226S | SKCM | 1 |
p.I357T | HNSC | 1 |
p.G135E | SKCM | 1 |
p.C486* | LUAD | 1 |
p.D221G | LIHC | 1 |
p.P393L | SKCM | 1 |
p.S450N | PAAD | 1 |
Top |
TissGeneCNV for CDSN |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CDSN |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CDSN |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CDSN |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CDSN |
TissGeneDrug for CDSN |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CDSN |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033860 | Psoriasis | 22 | BeFree,GAD |
umls:C1175175 | Severe Acute Respiratory Syndrome | 20 | BeFree |
umls:C0019163 | Hepatitis B | 14 | BeFree |
umls:C0037274 | Dermatologic disorders | 7 | BeFree |
umls:C0263361 | Psoriasis vulgaris | 7 | BeFree |
umls:C1854310 | Hypotrichosis simplex | 4 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
umls:C0042769 | Virus Diseases | 3 | BeFree |
umls:C1849193 | PEELING SKIN SYNDROME | 3 | BeFree |
umls:C0019159 | Hepatitis A | 2 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree,GAD |
umls:C0026769 | Multiple Sclerosis | 2 | BeFree,GAD |
umls:C0036421 | Systemic Scleroderma | 2 | BeFree |
umls:C0266999 | Vesicular Stomatitis | 2 | BeFree |
umls:C1258104 | Diffuse Scleroderma | 2 | BeFree |
umls:C1264606 | Persistent infection | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C3694279 | Middle East Respiratory Syndrome | 2 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0004943 | Behcet Syndrome | 1 | GAD |
umls:C0009782 | Connective Tissue Diseases | 1 | BeFree |
umls:C0014038 | Encephalitis | 1 | BeFree |
umls:C0015306 | Hereditary Multiple Exostoses | 1 | BeFree |
umls:C0017601 | Glaucoma | 1 | BeFree |
umls:C0018213 | Graves Disease | 1 | BeFree |
umls:C0019158 | Hepatitis | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0020678 | Hypotrichosis | 1 | LHGDN |
umls:C0023264 | Leigh Disease | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0025007 | Measles | 1 | BeFree |
umls:C0025362 | Mental Retardation | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
umls:C0033774 | Pruritus | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0037773 | Spastic Paraplegia, Hereditary | 1 | BeFree |
umls:C0040028 | Thrombocythemia, Essential | 1 | BeFree |
umls:C0040128 | Thyroid Diseases | 1 | BeFree |
umls:C0085620 | Flaccid paralysis | 1 | BeFree |
umls:C0242666 | Protein S Deficiency | 1 | BeFree |
umls:C0266929 | Chronic Periodontitis | 1 | BeFree |
umls:C0525045 | Mood Disorders | 1 | BeFree |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0584960 | Factor V Leiden mutation | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0870082 | Hyperkeratosis | 1 | BeFree |
umls:C1112211 | Hepatic infection | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1832588 | Chromosome 11p11.2 Deletion Syndrome | 1 | BeFree |
umls:C1853354 | Peeling skin syndrome, acral type | 1 | BeFree |
umls:C1840299 | Hypotrichosis Simplex of Scalp | 0 | CTD_human |
umls:C3891449 | PEELING SKIN SYNDROME 1 | 0 | ORPHANET |