 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for AGR2 |
 Gene summary |
| Basic gene information | Gene symbol | AGR2 |
| Gene name | anterior gradient 2 | |
| Synonyms | AG2|GOB-4|HAG-2|HEL-S-116|PDIA17|XAG-2 | |
| Cytomap | UCSC genome browser: 7p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006408.3, | |
| Description | AG-2HPC8anterior gradient homolog 2anterior gradient protein 2 homologepididymis secretory protein Li 116protein disulfide isomerase family A, member 17secreted cement gland homologsecreted cement gland protein XAG-2 homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606358 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106541 | ||
| HPRD : 05896 | ||
| Vega : OTTHUMG00000023446 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AGR2 | |
| BioGPS: 10551 | ||
| Pathway | NCI Pathway Interaction Database: AGR2 | |
| KEGG: AGR2 | ||
| REACTOME: AGR2 | ||
| Pathway Commons: AGR2 | ||
| Context | iHOP: AGR2 | |
| ligand binding site mutation search in PubMed: AGR2 | ||
| UCL Cancer Institute: AGR2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of AGR2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for AGR2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -6.408586761 | -0.999182761 | -5.409404 | 4.46E-15 | 9.27E-14 |
| THCA | 1.681810934 | -1.800155168 | 3.481966102 | 3.68E-18 | 9.05E-17 |
| BRCA | 4.061316257 | 2.116645204 | 1.944671053 | 3.15E-06 | 8.20E-06 |
| LUAD | 4.635324756 | 3.208560963 | 1.426763793 | 2.33E-05 | 6.48E-05 |
| KIRC | -6.313912983 | -0.731265761 | -5.582647222 | 1.31E-36 | 4.02E-35 |
| LUSC | 1.360248455 | 3.054491592 | -1.694243137 | 5.43E-06 | 1.27E-05 |
| HNSC | -0.230418668 | 1.192355751 | -1.422774419 | 0.017 | 0.038871951 |
| STAD | 6.459790489 | 3.731387364 | 2.728403125 | 0.00647 | 0.024011601 |
| KIRP | -4.029462636 | -0.700587636 | -3.328875 | 7.94E-05 | 0.000278583 |
| Top |
| TissGene-miRNA for AGR2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for AGR2 |
| TissGeneSNV for AGR2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R21T | LUAD | 1 |
| p.Y111H | KIRP | 1 |
| p.A167V | SKCM | 1 |
| p.M164I | SKCM | 1 |
| p.A155T | PAAD | 1 |
| p.Q103R | THCA | 1 |
| p.L12I | UCEC | 1 |
| p.H96D | CESC | 1 |
| p.A101T | PRAD | 1 |
| p.D162N | SKCM | 1 |
| p.R148C | SKCM | 1 |
| p.E96* | BLCA | 1 |
| p.K165R | LIHC | 1 |
| p.S7P | UCEC | 1 |
| p.R148H | UCEC | 1 |
| p.K88N | UCEC | 1 |
| p.S36F | BLCA | 1 |
| p.P5L | SKCM | 1 |
| p.G143V | SARC | 1 |
| p.N94S | COAD | 1 |
| Top |
| TissGeneCNV for AGR2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for AGR2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChimerDB 2.0 | NA | NA | AGR2-ESD | chr7:16805953 | chr13:46256453 | |
| Chimerdb3.0 | ChiTaRs | NA | AA306967 | AGR2-CSE1L | chr7:16832375 | chr20:47704579 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-AASX-11A | FLII-AGR2 | Out-of-Frame | chr17:18149247 | chr7:16839441 |
| Top |
| TissGeneNet for AGR2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (tumor) | AGR2, MLH1, POM121, MED31, CCDC90B, BRD7, CRMP1, UBQLN4, DDX5, POU5F1, LYPD3, TAGLN, MUC2 (normal) |
 |  |
| Top |
| TissGeneProg for AGR2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for AGR2 |
| TissGeneDrug for AGR2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for AGR2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027627 | Neoplasm Metastasis | 18 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 12 | BeFree |
| umls:C0600139 | Prostate carcinoma | 12 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 11 | BeFree |
| umls:C0678222 | Breast Carcinoma | 11 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 6 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 5 | BeFree |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree |
| umls:C0178874 | Tumor Progression | 4 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 4 | BeFree |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 4 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 4 | BeFree,CTD_human,LHGDN |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 3 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 3 | CTD_human,LHGDN |
| umls:C1140680 | Malignant neoplasm of ovary | 3 | BeFree |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree,LHGDN |
| umls:C0004096 | Asthma | 2 | BeFree |
| umls:C0007112 | Adenocarcinoma of prostate | 2 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 2 | BeFree,LHGDN |
| umls:C0030297 | Pancreatic Neoplasm | 2 | BeFree,LHGDN |
| umls:C1516170 | Cancer Cell Growth | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | GAD |
| umls:C0010346 | Crohn Disease | 1 | GAD |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0017168 | Gastroesophageal reflux disease | 1 | BeFree |
| umls:C0017185 | Gastrointestinal Neoplasms | 1 | LHGDN |
| umls:C0021100 | Bullous impetigo | 1 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 1 | BeFree |
| umls:C0030305 | Pancreatitis | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0262401 | Carcinoma of ampulla of Vater | 1 | BeFree |
| umls:C0272401 | Virchow's node (disorder) | 1 | BeFree |
| umls:C0600327 | Toxic Shock Syndrome | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699949 | airway disease | 1 | BeFree |
| umls:C0750952 | Biliary Tract Cancer | 1 | BeFree |
| umls:C0878500 | Intraepithelial Neoplasia | 1 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
| umls:C1168327 | High-Grade Prostatic Intraepithelial Neoplasia | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1301034 | Pancreatic intraepithelial neoplasia | 1 | BeFree |
| umls:C1328504 | Hormone refractory prostate cancer | 1 | BeFree |
| umls:C1334015 | High Grade Intraepithelial Neoplasia | 1 | BeFree |
| umls:C2987142 | Pancreatic Intraepithelial Neoplasia-1A | 1 | BeFree |
| umls:C3714602 | Staphylococcal toxic shock syndrome | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |