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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CEL
check button Gene summary
Basic gene informationGene symbolCEL
Gene namecarboxyl ester lipase
SynonymsBAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8
CytomapUCSC genome browser: 9q34.3
Type of geneprotein-coding
RefGenesNM_001807.4,
Descriptionbile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera
Modification date20141207
dbXrefs MIM : 114840
HGNC : HGNC
Ensembl : ENSG00000170835
HPRD : 07509
Vega : OTTHUMG00000020855
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CEL
BioGPS: 1056
PathwayNCI Pathway Interaction Database: CEL
KEGG: CEL
REACTOME: CEL
Pathway Commons: CEL
ContextiHOP: CEL
ligand binding site mutation search in PubMed: CEL
UCL Cancer Institute: CEL
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of CELExpression of a 46 kDa protein in human pancreatic tumors and its possible relationship with the bile salt-dependent lipase. Roudani S, Pasqualini E, Margotat A, Gastaldi M, Sbarra V, Malezet-Desmoulin C, Lombardo D. Eur J Cell Biol. 1994 Oct;65(1):132-44. (pmid:7889983)
go to article
Description by TissGene annotationsFused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006707cholesterol catabolic process12031288
GO:0030157pancreatic juice secretion1854805
GO:0006707cholesterol catabolic process12031288
GO:0030157pancreatic juice secretion1854805


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TissGeneExp for CEL

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP-3.1029046382.318557862-5.42146259.13E-205.53E-18
LUSC0.568414725-2.4457068443.0141215699.85E-103.36E-09
PRAD-2.012609446-0.026970984-1.9856384622.00E-082.29E-07
KIRC-3.5234032491.653168973-5.1765722224.70E-401.95E-38
LIHC-2.678862138-3.9474101381.2685480.0002720.000842555
COAD1.091354016-2.0166459843.1080.0002080.00070112


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TissGene-miRNA for CEL

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CEL
TissGeneSNV for CEL

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A725PCOAD3
p.P718TUVM2
p.P741LACC1
p.W491XSKCM1
p.G215WLUAD1
p.S248NSARC1
p.W491*SKCM1
p.V123ITGCT1
p.R237WREAD1
p.V414IBRCA1
p.T284ICOAD1
p.A278TCOAD1
p.G47CCOAD1
p.P68SSKCM1
p.G732CHNSC1
p.G219ALUAD1
p.P727LSKCM1
p.P230LSKCM1
p.T482IPAAD1
p.P694LSKCM1
p.P584LSKCM1
p.P718TSKCM1
p.S591ASKCM1
p.A471TGBM1
p.G244SCESC1
p.E265QLUAD1
p.P718TLUAD1
p.E735KBLCA1
p.G169AUCEC1
p.A456VGBM1
p.D460NBLCA1
p.Y514CHNSC1
p.T516MSKCM1
p.S442FSTAD1
p.N40SLGG1
p.E512KBLCA1
p.A593PSKCM1
p.Q749KOV1
p.K746ETGCT1
p.P323LUCEC1
p.A715PKIRP1
p.R237WSTAD1
p.G272CLUAD1
p.S657AKIRP1
p.P270SSKCM1
p.A692PESCA1
p.L235PSTAD1
p.P230SSKCM1
p.A321SLIHC1
p.V123IUCEC1
p.P576LSKCM1
p.P751SCOAD1
p.A692PPAAD1
p.A659PTHCA1
p.K115ECOAD1
p.P451SSKCM1
p.P738LSKCM1
p.R167CSTAD1
p.V717MCESC1
p.D499EBRCA1
p.T436AESCA1
p.T284SLUAD1
p.S175GSKCM1
p.P448LSKCM1
p.Y464CSTAD1
p.Q479RTHYM1
p.H510QSARC1
p.V555MUCEC1
p.L45PLIHC1
p.A202VBLCA1
p.R477QLGG1
p.G129ESKCM1
p.R156HSTAD1
p.P718SUCEC1
p.D557NBLCA1
p.T93ISKCM1
p.M750VSTAD1
p.A692PKIRC1
p.G172ALUAD1
p.W196LKIRP1
p.S49FSKCM1
p.R156HUCEC1
p.T482ALUSC1
p.Q749*BLCA1
p.H191YSTAD1
p.D460HBLCA1
p.A28TSTAD1
p.A737PLIHC1
p.T482ICESC1
p.T516MESCA1
p.R535WDLBC1
p.P751TCHOL1


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TissGeneCNV for CEL

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CEL

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAM54994PCYOX1-CELchr2:70504008chr9:135937365
TCGAfusionPortalPRADAPRADTCGA-EJ-5503-01ATSC1-CELIn-frameChr9:135796750Chr9:135945848


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TissGeneNet for CEL

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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COAD (tumor)COAD (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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HNSC (tumor)HNSC (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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KICH (tumor)KICH (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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KIRC (tumor)KIRC (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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KIRP (tumor)KIRP (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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LIHC (tumor)LIHC (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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LUAD (tumor)LUAD (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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LUSC (tumor)LUSC (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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PRAD (tumor)PRAD (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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STAD (tumor)STAD (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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THCA (tumor)THCA (normal)
CEL, LTF, BPGM (tumor)CEL, LTF, BPGM (normal)
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TissGeneProg for CEL

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CEL
TissGeneDrug for CEL

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CEL

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0032580Adenomatous Polyposis Coli20BeFree
umls:C0206245Amyloid Neuropathies, Familial12BeFree
umls:C1527249Colorectal Cancer12BeFree
umls:C0008384Cholesterol Ester Storage Disease11BeFree
umls:C0009402Colorectal Carcinoma11BeFree
umls:C0001430Adenoma10BeFree
umls:C0019693HIV Infections7BeFree
umls:C0004096Asthma6BeFree
umls:C0011847Diabetes6BeFree
umls:C0011849Diabetes Mellitus6BeFree
umls:C0152025Polyneuropathy6BeFree
umls:C0334108Multiple polyps6BeFree
umls:C0043208Wolman Disease5BeFree
umls:C0346421Chronic eosinophilic leukemia5BeFree
umls:C1333990Hereditary Nonpolyposis Colorectal Cancer5BeFree
umls:C1853297MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION5BeFree,CLINVAR,CTD_human
umls:C0001418Adenocarcinoma4BeFree
umls:C0206141Idiopathic Hypereosinophilic Syndrome4BeFree
umls:C2674616FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder)4BeFree
umls:C3272841MUTYH-Associate Polyposis4BeFree
umls:C0002726Amyloidosis3BeFree
umls:C0004153Atherosclerosis3BeFree,GAD
umls:C0007102Malignant tumor of colon3BeFree
umls:C0010068Coronary heart disease3BeFree
umls:C0023801Lipomatosis3BeFree
umls:C0032285Pneumonia3BeFree
umls:C0032584polyps3BeFree
umls:C0036202Sarcoidosis3BeFree
umls:C0079218Fibromatosis, Aggressive3BeFree
umls:C0263662Disseminated eosinophilic collagen disease3BeFree
umls:C0342276Maturity onset diabetes mellitus in young3BeFree
umls:C0699790Colon Carcinoma3BeFree
umls:C1540912Hypereosinophilic syndrome3BeFree
umls:C1701940Pneumonia, Ventilator-Associated3BeFree
umls:C2931642Benign symmetrical lipomatosis3BeFree
umls:C0003850Arteriosclerosis2BeFree
umls:C0010054Coronary Arteriosclerosis2BeFree
umls:C0017097Gardner Syndrome2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0024117Chronic Obstructive Airway Disease2BeFree
umls:C0030286Pancreatic Diseases2BeFree
umls:C0034050Pulmonary Alveolar Proteinosis2BeFree
umls:C0036205Sarcoidosis, Pulmonary2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0041327Tuberculosis, Pulmonary2BeFree
umls:C0085669Acute leukemia2BeFree
umls:C0149521Pancreatitis, Chronic2BeFree,CTD_human
umls:C0206708Cervical Intraepithelial Neoplasia2BeFree
umls:C0268407Senile cardiac amyloidosis2BeFree
umls:C0276653Invasive Pulmonary Aspergillosis2BeFree
umls:C0332887Congenital hypertrophy2BeFree
umls:C0442874Neuropathy2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0936273Familial Amyloid Polyneuropathy, Type IV2BeFree
umls:C1261473Sarcoma2BeFree
umls:C1535939Pneumocystis jiroveci pneumonia2BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis2BeFree
umls:C1956346Coronary Artery Disease2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C2936349Plaque, Amyloid2BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0004623Bacterial Infections1BeFree
umls:C0006625Cachexia1BeFree
umls:C0007113Rectal Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0007286Carpal Tunnel Syndrome1BeFree
umls:C0009376Colonic Polyps1BeFree
umls:C0010200Coughing1BeFree
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0011991Diarrhea1BeFree
umls:C0022521Kartagener Syndrome1BeFree
umls:C0022602Actinic keratosis1BeFree
umls:C0023434Chronic Lymphocytic Leukemia1BeFree
umls:C0023481Chronic Neutrophilic Leukemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024314Lymphoproliferative Disorders1BeFree
umls:C0024530Malaria1BeFree
umls:C0026936Mycoplasma Infections1BeFree
umls:C0027796Neuralgia1BeFree
umls:C0028754Obesity1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0030283Pancreatic Cyst1BeFree
umls:C0030297Pancreatic Neoplasm1BeFree
umls:C0030305Pancreatitis1BeFree,GAD,LHGDN
umls:C0032463Polycythemia Vera1BeFree
umls:C0034063Pulmonary Edema1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0035204Respiration Disorders1BeFree
umls:C0035335Retinoblastoma1BeFree
umls:C0041296Tuberculosis1BeFree
umls:C0043144Wheezing1BeFree
umls:C0085605Liver Failure1BeFree
umls:C0152014Atrophy of pancreas1BeFree
umls:C0162429Malnutrition1BeFree
umls:C0162557Liver Failure, Acute1BeFree
umls:C0206062Lung Diseases, Interstitial1BeFree
umls:C0206247Amyloid Neuropathies1BeFree
umls:C0242459Simple Pulmonary Eosinophilia1BeFree
umls:C0242647Mucosa-Associated Lymphoid Tissue Lymphoma1BeFree
umls:C0264219Acute respiratory disease1BeFree
umls:C0268384Familial Amyloid Neuropathy, Portuguese Type1BeFree
umls:C0275524Coinfection1BeFree
umls:C0278804Adenocarcinoma of duodenum1BeFree
umls:C0341470Alcohol-induced chronic pancreatitis1BeFree
umls:C0341471Idiopathic chronic pancreatitis1BeFree
umls:C0376670Pancreatitis, Alcoholic1BeFree,GAD
umls:C0524620Metabolic Syndrome X1BeFree
umls:C0553694Oropharyngeal disorders1BeFree
umls:C0677776Hereditary Breast and Ovarian Cancer Syndrome1BeFree
umls:C0751658Ulnar Nerve Entrapment Syndrome1BeFree
umls:C0815107psychological distress1BeFree
umls:C0856169Endothelial dysfunction1BeFree
umls:C0879615Stromal Neoplasm1BeFree
umls:C0949059Polyp of large intestine1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1142553Primary HIV infection1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1328061Myelodysplastic/myeloproliferative neoplasm, unclassifiable1BeFree
umls:C1443924Severe diarrhea1BeFree
umls:C1708187Gardner fibroma1BeFree
umls:C2718001Protein Misfolding Disorders1BeFree
umls:C2751492AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED1BeFree
umls:C2936797Acid cholesteryl ester hydrolase deficiency, type 21BeFree
umls:C3665444Neutrophilia (disorder)1BeFree
umls:C3714636Pneumonitis1BeFree