TissGeneSummary for CEL |
Gene summary |
Basic gene information | Gene symbol | CEL |
Gene name | carboxyl ester lipase | |
Synonyms | BAL|BSDL|BSSL|CELL|CEase|FAP|FAPP|LIPA|MODY8 | |
Cytomap | UCSC genome browser: 9q34.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001807.4, | |
Description | bile salt-activated lipasebile salt-dependent lipase, oncofetal isoformbucelipasecarboxyl ester hydrolasecarboxyl ester lipase (bile salt-stimulated lipase)cholesterol esterasefetoacinar pancreatic proteinlysophospholipase, pancreaticsterol estera | |
Modification date | 20141207 | |
dbXrefs | MIM : 114840 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170835 | ||
HPRD : 07509 | ||
Vega : OTTHUMG00000020855 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CEL | |
BioGPS: 1056 | ||
Pathway | NCI Pathway Interaction Database: CEL | |
KEGG: CEL | ||
REACTOME: CEL | ||
Pathway Commons: CEL | ||
Context | iHOP: CEL | |
ligand binding site mutation search in PubMed: CEL | ||
UCL Cancer Institute: CEL | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of CEL | Expression of a 46 kDa protein in human pancreatic tumors and its possible relationship with the bile salt-dependent lipase. Roudani S, Pasqualini E, Margotat A, Gastaldi M, Sbarra V, Malezet-Desmoulin C, Lombardo D. Eur J Cell Biol. 1994 Oct;65(1):132-44. (pmid:7889983) go to article | |
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006707 | cholesterol catabolic process | 12031288 | GO:0030157 | pancreatic juice secretion | 1854805 | GO:0006707 | cholesterol catabolic process | 12031288 | GO:0030157 | pancreatic juice secretion | 1854805 |
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TissGeneExp for CEL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -3.102904638 | 2.318557862 | -5.4214625 | 9.13E-20 | 5.53E-18 |
LUSC | 0.568414725 | -2.445706844 | 3.014121569 | 9.85E-10 | 3.36E-09 |
PRAD | -2.012609446 | -0.026970984 | -1.985638462 | 2.00E-08 | 2.29E-07 |
KIRC | -3.523403249 | 1.653168973 | -5.176572222 | 4.70E-40 | 1.95E-38 |
LIHC | -2.678862138 | -3.947410138 | 1.268548 | 0.000272 | 0.000842555 |
COAD | 1.091354016 | -2.016645984 | 3.108 | 0.000208 | 0.00070112 |
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TissGene-miRNA for CEL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CEL |
TissGeneSNV for CEL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A725P | COAD | 3 |
p.P718T | UVM | 2 |
p.P741L | ACC | 1 |
p.W491X | SKCM | 1 |
p.G215W | LUAD | 1 |
p.S248N | SARC | 1 |
p.W491* | SKCM | 1 |
p.V123I | TGCT | 1 |
p.R237W | READ | 1 |
p.V414I | BRCA | 1 |
p.T284I | COAD | 1 |
p.A278T | COAD | 1 |
p.G47C | COAD | 1 |
p.P68S | SKCM | 1 |
p.G732C | HNSC | 1 |
p.G219A | LUAD | 1 |
p.P727L | SKCM | 1 |
p.P230L | SKCM | 1 |
p.T482I | PAAD | 1 |
p.P694L | SKCM | 1 |
p.P584L | SKCM | 1 |
p.P718T | SKCM | 1 |
p.S591A | SKCM | 1 |
p.A471T | GBM | 1 |
p.G244S | CESC | 1 |
p.E265Q | LUAD | 1 |
p.P718T | LUAD | 1 |
p.E735K | BLCA | 1 |
p.G169A | UCEC | 1 |
p.A456V | GBM | 1 |
p.D460N | BLCA | 1 |
p.Y514C | HNSC | 1 |
p.T516M | SKCM | 1 |
p.S442F | STAD | 1 |
p.N40S | LGG | 1 |
p.E512K | BLCA | 1 |
p.A593P | SKCM | 1 |
p.Q749K | OV | 1 |
p.K746E | TGCT | 1 |
p.P323L | UCEC | 1 |
p.A715P | KIRP | 1 |
p.R237W | STAD | 1 |
p.G272C | LUAD | 1 |
p.S657A | KIRP | 1 |
p.P270S | SKCM | 1 |
p.A692P | ESCA | 1 |
p.L235P | STAD | 1 |
p.P230S | SKCM | 1 |
p.A321S | LIHC | 1 |
p.V123I | UCEC | 1 |
p.P576L | SKCM | 1 |
p.P751S | COAD | 1 |
p.A692P | PAAD | 1 |
p.A659P | THCA | 1 |
p.K115E | COAD | 1 |
p.P451S | SKCM | 1 |
p.P738L | SKCM | 1 |
p.R167C | STAD | 1 |
p.V717M | CESC | 1 |
p.D499E | BRCA | 1 |
p.T436A | ESCA | 1 |
p.T284S | LUAD | 1 |
p.S175G | SKCM | 1 |
p.P448L | SKCM | 1 |
p.Y464C | STAD | 1 |
p.Q479R | THYM | 1 |
p.H510Q | SARC | 1 |
p.V555M | UCEC | 1 |
p.L45P | LIHC | 1 |
p.A202V | BLCA | 1 |
p.R477Q | LGG | 1 |
p.G129E | SKCM | 1 |
p.R156H | STAD | 1 |
p.P718S | UCEC | 1 |
p.D557N | BLCA | 1 |
p.T93I | SKCM | 1 |
p.M750V | STAD | 1 |
p.A692P | KIRC | 1 |
p.G172A | LUAD | 1 |
p.W196L | KIRP | 1 |
p.S49F | SKCM | 1 |
p.R156H | UCEC | 1 |
p.T482A | LUSC | 1 |
p.Q749* | BLCA | 1 |
p.H191Y | STAD | 1 |
p.D460H | BLCA | 1 |
p.A28T | STAD | 1 |
p.A737P | LIHC | 1 |
p.T482I | CESC | 1 |
p.T516M | ESCA | 1 |
p.R535W | DLBC | 1 |
p.P751T | CHOL | 1 |
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TissGeneCNV for CEL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CEL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | M54994 | PCYOX1-CEL | chr2:70504008 | chr9:135937365 | |
TCGAfusionPortal | PRADA | PRAD | TCGA-EJ-5503-01A | TSC1-CEL | In-frame | Chr9:135796750 | Chr9:135945848 |
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TissGeneNet for CEL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CEL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CEL |
TissGeneDrug for CEL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CEL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0032580 | Adenomatous Polyposis Coli | 20 | BeFree |
umls:C0206245 | Amyloid Neuropathies, Familial | 12 | BeFree |
umls:C1527249 | Colorectal Cancer | 12 | BeFree |
umls:C0008384 | Cholesterol Ester Storage Disease | 11 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 11 | BeFree |
umls:C0001430 | Adenoma | 10 | BeFree |
umls:C0019693 | HIV Infections | 7 | BeFree |
umls:C0004096 | Asthma | 6 | BeFree |
umls:C0011847 | Diabetes | 6 | BeFree |
umls:C0011849 | Diabetes Mellitus | 6 | BeFree |
umls:C0152025 | Polyneuropathy | 6 | BeFree |
umls:C0334108 | Multiple polyps | 6 | BeFree |
umls:C0043208 | Wolman Disease | 5 | BeFree |
umls:C0346421 | Chronic eosinophilic leukemia | 5 | BeFree |
umls:C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 5 | BeFree |
umls:C1853297 | MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION | 5 | BeFree,CLINVAR,CTD_human |
umls:C0001418 | Adenocarcinoma | 4 | BeFree |
umls:C0206141 | Idiopathic Hypereosinophilic Syndrome | 4 | BeFree |
umls:C2674616 | FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder) | 4 | BeFree |
umls:C3272841 | MUTYH-Associate Polyposis | 4 | BeFree |
umls:C0002726 | Amyloidosis | 3 | BeFree |
umls:C0004153 | Atherosclerosis | 3 | BeFree,GAD |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0010068 | Coronary heart disease | 3 | BeFree |
umls:C0023801 | Lipomatosis | 3 | BeFree |
umls:C0032285 | Pneumonia | 3 | BeFree |
umls:C0032584 | polyps | 3 | BeFree |
umls:C0036202 | Sarcoidosis | 3 | BeFree |
umls:C0079218 | Fibromatosis, Aggressive | 3 | BeFree |
umls:C0263662 | Disseminated eosinophilic collagen disease | 3 | BeFree |
umls:C0342276 | Maturity onset diabetes mellitus in young | 3 | BeFree |
umls:C0699790 | Colon Carcinoma | 3 | BeFree |
umls:C1540912 | Hypereosinophilic syndrome | 3 | BeFree |
umls:C1701940 | Pneumonia, Ventilator-Associated | 3 | BeFree |
umls:C2931642 | Benign symmetrical lipomatosis | 3 | BeFree |
umls:C0003850 | Arteriosclerosis | 2 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
umls:C0017097 | Gardner Syndrome | 2 | BeFree |
umls:C0019163 | Hepatitis B | 2 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 2 | BeFree |
umls:C0030286 | Pancreatic Diseases | 2 | BeFree |
umls:C0034050 | Pulmonary Alveolar Proteinosis | 2 | BeFree |
umls:C0036205 | Sarcoidosis, Pulmonary | 2 | BeFree |
umls:C0036421 | Systemic Scleroderma | 2 | BeFree |
umls:C0041327 | Tuberculosis, Pulmonary | 2 | BeFree |
umls:C0085669 | Acute leukemia | 2 | BeFree |
umls:C0149521 | Pancreatitis, Chronic | 2 | BeFree,CTD_human |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 2 | BeFree |
umls:C0268407 | Senile cardiac amyloidosis | 2 | BeFree |
umls:C0276653 | Invasive Pulmonary Aspergillosis | 2 | BeFree |
umls:C0332887 | Congenital hypertrophy | 2 | BeFree |
umls:C0442874 | Neuropathy | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0936273 | Familial Amyloid Polyneuropathy, Type IV | 2 | BeFree |
umls:C1261473 | Sarcoma | 2 | BeFree |
umls:C1535939 | Pneumocystis jiroveci pneumonia | 2 | BeFree |
umls:C1800706 | Idiopathic Pulmonary Fibrosis | 2 | BeFree |
umls:C1956346 | Coronary Artery Disease | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C2936349 | Plaque, Amyloid | 2 | BeFree |
umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
umls:C0004623 | Bacterial Infections | 1 | BeFree |
umls:C0006625 | Cachexia | 1 | BeFree |
umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
umls:C0007286 | Carpal Tunnel Syndrome | 1 | BeFree |
umls:C0009376 | Colonic Polyps | 1 | BeFree |
umls:C0010200 | Coughing | 1 | BeFree |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0011991 | Diarrhea | 1 | BeFree |
umls:C0022521 | Kartagener Syndrome | 1 | BeFree |
umls:C0022602 | Actinic keratosis | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0023481 | Chronic Neutrophilic Leukemia | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0024314 | Lymphoproliferative Disorders | 1 | BeFree |
umls:C0024530 | Malaria | 1 | BeFree |
umls:C0026936 | Mycoplasma Infections | 1 | BeFree |
umls:C0027796 | Neuralgia | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0030283 | Pancreatic Cyst | 1 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
umls:C0030305 | Pancreatitis | 1 | BeFree,GAD,LHGDN |
umls:C0032463 | Polycythemia Vera | 1 | BeFree |
umls:C0034063 | Pulmonary Edema | 1 | BeFree |
umls:C0034069 | Pulmonary Fibrosis | 1 | BeFree |
umls:C0035204 | Respiration Disorders | 1 | BeFree |
umls:C0035335 | Retinoblastoma | 1 | BeFree |
umls:C0041296 | Tuberculosis | 1 | BeFree |
umls:C0043144 | Wheezing | 1 | BeFree |
umls:C0085605 | Liver Failure | 1 | BeFree |
umls:C0152014 | Atrophy of pancreas | 1 | BeFree |
umls:C0162429 | Malnutrition | 1 | BeFree |
umls:C0162557 | Liver Failure, Acute | 1 | BeFree |
umls:C0206062 | Lung Diseases, Interstitial | 1 | BeFree |
umls:C0206247 | Amyloid Neuropathies | 1 | BeFree |
umls:C0242459 | Simple Pulmonary Eosinophilia | 1 | BeFree |
umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
umls:C0264219 | Acute respiratory disease | 1 | BeFree |
umls:C0268384 | Familial Amyloid Neuropathy, Portuguese Type | 1 | BeFree |
umls:C0275524 | Coinfection | 1 | BeFree |
umls:C0278804 | Adenocarcinoma of duodenum | 1 | BeFree |
umls:C0341470 | Alcohol-induced chronic pancreatitis | 1 | BeFree |
umls:C0341471 | Idiopathic chronic pancreatitis | 1 | BeFree |
umls:C0376670 | Pancreatitis, Alcoholic | 1 | BeFree,GAD |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C0553694 | Oropharyngeal disorders | 1 | BeFree |
umls:C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 1 | BeFree |
umls:C0751658 | Ulnar Nerve Entrapment Syndrome | 1 | BeFree |
umls:C0815107 | psychological distress | 1 | BeFree |
umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
umls:C0879615 | Stromal Neoplasm | 1 | BeFree |
umls:C0949059 | Polyp of large intestine | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1142553 | Primary HIV infection | 1 | BeFree |
umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
umls:C1328061 | Myelodysplastic/myeloproliferative neoplasm, unclassifiable | 1 | BeFree |
umls:C1443924 | Severe diarrhea | 1 | BeFree |
umls:C1708187 | Gardner fibroma | 1 | BeFree |
umls:C2718001 | Protein Misfolding Disorders | 1 | BeFree |
umls:C2751492 | AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED | 1 | BeFree |
umls:C2936797 | Acid cholesteryl ester hydrolase deficiency, type 2 | 1 | BeFree |
umls:C3665444 | Neutrophilia (disorder) | 1 | BeFree |
umls:C3714636 | Pneumonitis | 1 | BeFree |