TissGeneSummary for AKAP3 |
Gene summary |
Basic gene information | Gene symbol | AKAP3 |
Gene name | A kinase (PRKA) anchor protein 3 | |
Synonyms | AKAP 110|AKAP110|CT82|FSP95|HEL159|PRKA3|SOB1 | |
Cytomap | UCSC genome browser: 12p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001278309.1, NM_006422.3, | |
Description | A-kinase anchor protein 3A-kinase anchor protein, 110kDaFibrous Sheath Protein of 95 kDacancer/testis antigen 82epididymis luminal protein 159fibrousheathin Ifibrousheathin-1protein kinase A binding protein AKAP 110protein kinase A-anchoring prote | |
Modification date | 20141207 | |
dbXrefs | MIM : 604689 | |
HGNC : HGNC | ||
Ensembl : ENSG00000111254 | ||
HPRD : 05256 | ||
Vega : OTTHUMG00000168226 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AKAP3 | |
BioGPS: 10566 | ||
Pathway | NCI Pathway Interaction Database: AKAP3 | |
KEGG: AKAP3 | ||
REACTOME: AKAP3 | ||
Pathway Commons: AKAP3 | ||
Context | iHOP: AKAP3 | |
ligand binding site mutation search in PubMed: AKAP3 | ||
UCL Cancer Institute: AKAP3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of AKAP3 | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for AKAP3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 1.030462029 | 2.627287029 | -1.596825 | 1.98E-06 | 9.35E-06 |
KICH | 0.374676279 | 2.928000279 | -2.553324 | 7.88E-11 | 6.22E-10 |
BRCA | 0.486822665 | 1.582666525 | -1.09584386 | 2.74E-14 | 1.37E-13 |
KIRC | 0.435190502 | 2.842768279 | -2.407577778 | 5.00E-34 | 1.23E-32 |
HNSC | 0.01863107 | 1.093300837 | -1.074669767 | 1.71E-06 | 1.21E-05 |
LIHC | -0.223581721 | 1.131056279 | -1.354638 | 1.78E-07 | 1.17E-06 |
THCA | 1.00166489 | 2.39885472 | -1.397189831 | 9.07E-15 | 1.12E-13 |
ESCA | -0.809431721 | 1.04577737 | -1.855209091 | 0.000934 | 0.013941047 |
Top |
TissGene-miRNA for AKAP3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for AKAP3 |
TissGeneSNV for AKAP3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D702Y | UCEC | 1 |
p.R60Q | SKCM | 1 |
p.V344I | LUAD | 1 |
p.S208I | PAAD | 1 |
p.E65* | UCEC | 1 |
p.V344I | COAD | 1 |
p.S21F | READ | 1 |
p.K327N | SKCM | 1 |
p.V344I | SARC | 1 |
p.R263W | UCEC | 1 |
p.D148N | ESCA | 1 |
p.V344L | LUAD | 1 |
p.A531V | SKCM | 1 |
p.N600S | UCEC | 1 |
p.G258X | UCS | 1 |
p.N152K | SKCM | 1 |
p.H538Y | SKCM | 1 |
p.L159S | UCEC | 1 |
p.P488H | COAD | 1 |
p.E583X | READ | 1 |
p.L333I | PAAD | 1 |
p.A446V | UCEC | 1 |
p.R591K | SKCM | 1 |
p.S125F | SKCM | 1 |
p.Q774H | LUSC | 1 |
p.V183I | ESCA | 1 |
p.A782S | STAD | 1 |
p.V183I | LGG | 1 |
p.T36M | UCEC | 1 |
p.E264K | SKCM | 1 |
p.L318Q | LIHC | 1 |
p.S331L | SKCM | 1 |
p.A279V | READ | 1 |
p.A634V | UCEC | 1 |
p.V308A | UCEC | 1 |
p.S248F | LUSC | 1 |
p.A185T | THYM | 1 |
p.S592G | PRAD | 1 |
p.R269L | LUSC | 1 |
p.R60W | STAD | 1 |
p.Q541H | UCEC | 1 |
p.N117S | STAD | 1 |
p.Y715D | LUAD | 1 |
p.R431T | HNSC | 1 |
p.E514D | LUAD | 1 |
p.S493F | LGG | 1 |
p.R591M | UCEC | 1 |
p.S331L | ESCA | 1 |
p.P749L | STAD | 1 |
p.Q778* | CESC | 1 |
p.S299C | HNSC | 1 |
p.D335N | BLCA | 1 |
p.K608N | LUSC | 1 |
p.E511D | CESC | 1 |
p.R486H | STAD | 1 |
p.P749S | SKCM | 1 |
p.T312A | STAD | 1 |
p.L650F | SKCM | 1 |
p.W30* | SKCM | 1 |
p.S356L | SKCM | 1 |
p.R269Q | CESC | 1 |
p.Q774* | SKCM | 1 |
p.G258* | UCS | 1 |
p.Q778* | SKCM | 1 |
p.P513R | LUAD | 1 |
p.K359Q | UCEC | 1 |
p.A753T | UCEC | 1 |
p.C108F | LUSC | 1 |
p.R418Q | SKCM | 1 |
p.S691L | COAD | 1 |
p.G251R | STAD | 1 |
p.A561T | UCEC | 1 |
p.V622F | LUAD | 1 |
p.A540S | LUSC | 1 |
p.F261L | LUAD | 1 |
p.S35Y | LUAD | 1 |
p.F363L | UCEC | 1 |
p.E55K | LIHC | 1 |
p.D569N | UCEC | 1 |
p.P568L | SKCM | 1 |
p.R269Q | SKCM | 1 |
p.P637L | SKCM | 1 |
p.P230S | SKCM | 1 |
p.T278M | STAD | 1 |
p.G118R | BRCA | 1 |
p.E511G | LUAD | 1 |
p.Q778* | BLCA | 1 |
p.V787A | COAD | 1 |
p.H393Y | UCEC | 1 |
p.S651C | BLCA | 1 |
p.N211H | UCEC | 1 |
p.L628F | CESC | 1 |
p.E402A | ESCA | 1 |
p.Y435N | LUAD | 1 |
p.A191V | LIHC | 1 |
p.R267G | LUAD | 1 |
p.R140H | UCEC | 1 |
p.D697H | CESC | 1 |
p.A576T | UCEC | 1 |
p.F710V | SKCM | 1 |
p.G13X | KIRC | 1 |
p.S294C | BLCA | 1 |
p.E716Q | DLBC | 1 |
p.S612R | CESC | 1 |
p.S223N | LUAD | 1 |
p.R201K | BLCA | 1 |
p.G75A | HNSC | 1 |
p.D148N | LUAD | 1 |
p.R269Q | HNSC | 1 |
p.V776I | PRAD | 1 |
p.A553V | SKCM | 1 |
p.G838V | COAD | 1 |
p.G13R | HNSC | 1 |
p.P497A | KIRP | 1 |
p.E614K | SKCM | 1 |
p.W30X | SKCM | 1 |
p.S2L | STAD | 1 |
p.S700F | COAD | 1 |
p.Q541R | SKCM | 1 |
p.I683L | UCEC | 1 |
p.V14I | SKCM | 1 |
p.R545S | OV | 1 |
p.K169T | READ | 1 |
p.Q660X | ESCA | 1 |
p.E123X | READ | 1 |
p.R60Q | STAD | 1 |
p.R255I | OV | 1 |
p.E828K | BLCA | 1 |
p.R486H | UCEC | 1 |
p.D399N | ESCA | 1 |
p.D499N | LUSC | 1 |
p.H738Y | SKCM | 1 |
p.S493F | HNSC | 1 |
p.S807L | LUSC | 1 |
p.T765M | HNSC | 1 |
p.S336F | SKCM | 1 |
p.A576S | LIHC | 1 |
p.I500T | COAD | 1 |
p.E727* | STAD | 1 |
p.V820I | SKCM | 1 |
p.K213T | KIRP | 1 |
p.K153N | SKCM | 1 |
Top |
TissGeneCNV for AKAP3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for AKAP3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW512277 | AKAP3-AKAP3 | chr12:4724791 | chr12:4724784 | |
Chimerdb3.0 | FusionScan | LUAD | TCGA-86-8073-01A | KDM3B-AKAP3 | In-Frame | chr5:137688676 | chr12:4725060 |
Top |
TissGeneNet for AKAP3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for AKAP3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for AKAP3 |
TissGeneDrug for AKAP3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for AKAP3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0153594 | Malignant neoplasm of testis | 3 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |