TissGeneSummary for C6orf10 |
Gene summary |
Basic gene information | Gene symbol | C6orf10 |
Gene name | chromosome 6 open reading frame 10 | |
Synonyms | TSBP | |
Cytomap | UCSC genome browser: 6p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001286474.1, NM_001286475.1,NM_006781.4, | |
Description | testis specific basic proteinuncharacterized protein C6orf10 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000204296 | ||
HPRD : 09851 | ||
Vega : OTTHUMG00000031107 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C6orf10 | |
BioGPS: 10665 | ||
Pathway | NCI Pathway Interaction Database: C6orf10 | |
KEGG: C6orf10 | ||
REACTOME: C6orf10 | ||
Pathway Commons: C6orf10 | ||
Context | iHOP: C6orf10 | |
ligand binding site mutation search in PubMed: C6orf10 | ||
UCL Cancer Institute: C6orf10 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C6orf10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C6orf10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.294327974 | -0.413046536 | 1.70737451 | 3.63E-07 | 9.53E-07 |
HNSC | 2.745935407 | 0.074009825 | 2.671925581 | 9.72E-13 | 3.65E-11 |
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TissGene-miRNA for C6orf10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C6orf10 |
TissGeneSNV for C6orf10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G392R | SKCM | 2 |
p.T431N | CESC | 1 |
p.K284E | SARC | 1 |
p.E368K | SKCM | 1 |
p.S477L | BLCA | 1 |
p.E272K | SKCM | 1 |
p.E99K | SKCM | 1 |
p.S170P | BRCA | 1 |
p.G523C | LUSC | 1 |
p.G319R | LUAD | 1 |
p.E461Q | BLCA | 1 |
p.K286I | LUAD | 1 |
p.A432G | LUAD | 1 |
p.G496R | SKCM | 1 |
p.K225* | HNSC | 1 |
p.E284Q | BLCA | 1 |
p.Q71H | LUAD | 1 |
p.K384T | KIRP | 1 |
p.E534K | SKCM | 1 |
p.D494N | SKCM | 1 |
p.K429N | BLCA | 1 |
p.E462Q | BLCA | 1 |
p.S478L | BLCA | 1 |
p.P177A | BLCA | 1 |
p.T215A | LGG | 1 |
p.K369N | LUAD | 1 |
p.K339Q | STAD | 1 |
p.E536K | SKCM | 1 |
p.E414Q | CESC | 1 |
p.R29L | HNSC | 1 |
p.M175I | BLCA | 1 |
p.E515K | UCEC | 1 |
p.S545L | SKCM | 1 |
p.K488N | BLCA | 1 |
p.E503K | SKCM | 1 |
p.I19S | HNSC | 1 |
p.S470F | SKCM | 1 |
p.G482R | SKCM | 1 |
p.E127* | STAD | 1 |
p.R90Q | SKCM | 1 |
p.L15P | COAD | 1 |
p.T124A | LIHC | 1 |
p.T238N | LUAD | 1 |
p.E469K | SKCM | 1 |
p.S415N | LGG | 1 |
p.K444T | LGG | 1 |
p.G299V | LUSC | 1 |
p.K430N | BLCA | 1 |
p.S463I | SARC | 1 |
p.P330L | SKCM | 1 |
p.G356E | SKCM | 1 |
p.E276K | SKCM | 1 |
p.S387F | SKCM | 1 |
p.D499N | SKCM | 1 |
p.E502V | GBM | 1 |
p.E501Q | BLCA | 1 |
p.K532N | LUAD | 1 |
p.G320R | LUAD | 1 |
p.G452R | SKCM | 1 |
p.T353M | SKCM | 1 |
p.K489T | HNSC | 1 |
p.M372I | SKCM | 1 |
p.G531E | SKCM | 1 |
p.K287I | LUAD | 1 |
p.G407R | SKCM | 1 |
p.E276D | SKCM | 1 |
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TissGeneCNV for C6orf10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C6orf10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE089934 | FIBIN-C6orf10 | chr11:27016775 | chr6:3641779 |
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TissGeneNet for C6orf10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C6orf10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C6orf10 |
TissGeneDrug for C6orf10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C6orf10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003873 | Rheumatoid Arthritis | 5 | GAD,GWASCAT |
umls:C0024141 | Lupus Erythematosus, Systemic | 3 | GAD |
umls:C0026769 | Multiple Sclerosis | 3 | GAD,GWASCAT |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | GAD |
umls:C0000786 | Spontaneous abortion | 1 | GAD |
umls:C0003864 | Arthritis | 1 | GWASCAT |
umls:C0004096 | Asthma | 1 | GAD,GWASCAT |
umls:C0008312 | Primary biliary cirrhosis | 1 | GAD,GWASCAT |
umls:C0010068 | Coronary heart disease | 1 | GWASCAT |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0011615 | Dermatitis, Atopic | 1 | GWASCAT |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0018213 | Graves Disease | 1 | GAD,GWASCAT |
umls:C0018799 | Heart Diseases | 1 | GAD |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0022658 | Kidney Diseases | 1 | GWASCAT |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GWASCAT |
umls:C0033860 | Psoriasis | 1 | GAD |
umls:C0036421 | Systemic Scleroderma | 1 | GWASCAT |
umls:C0086445 | Idiopathic Membranous Glomerulonephritis | 1 | GWASCAT |
umls:C0238065 | Biliary Cirrhosis, Secondary | 1 | GWASCAT |
umls:C0409979 | Neonatal Systemic lupus erythematosus | 1 | BeFree |
umls:C0860207 | Drug-Induced Liver Injury | 1 | GAD |
umls:C1847540 | Azoospermia, Nonobstructive | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |
umls:C3495559 | Juvenile arthritis | 1 | GAD |