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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for C6orf10
check button Gene summary
Basic gene informationGene symbolC6orf10
Gene namechromosome 6 open reading frame 10
SynonymsTSBP
CytomapUCSC genome browser: 6p21.3
Type of geneprotein-coding
RefGenesNM_001286474.1,
NM_001286475.1,NM_006781.4,
Descriptiontestis specific basic proteinuncharacterized protein C6orf10
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000204296
HPRD : 09851
Vega : OTTHUMG00000031107
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_C6orf10
BioGPS: 10665
PathwayNCI Pathway Interaction Database: C6orf10
KEGG: C6orf10
REACTOME: C6orf10
Pathway Commons: C6orf10
ContextiHOP: C6orf10
ligand binding site mutation search in PubMed: C6orf10
UCL Cancer Institute: C6orf10
Assigned class in TissGDB*B
Included tissue-specific gene expression resources
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of C6orf10
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for C6orf10

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC1.294327974-0.4130465361.707374513.63E-079.53E-07
HNSC2.7459354070.0740098252.6719255819.72E-133.65E-11


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TissGene-miRNA for C6orf10

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for C6orf10
TissGeneSNV for C6orf10

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G392RSKCM2
p.T431NCESC1
p.K284ESARC1
p.E368KSKCM1
p.S477LBLCA1
p.E272KSKCM1
p.E99KSKCM1
p.S170PBRCA1
p.G523CLUSC1
p.G319RLUAD1
p.E461QBLCA1
p.K286ILUAD1
p.A432GLUAD1
p.G496RSKCM1
p.K225*HNSC1
p.E284QBLCA1
p.Q71HLUAD1
p.K384TKIRP1
p.E534KSKCM1
p.D494NSKCM1
p.K429NBLCA1
p.E462QBLCA1
p.S478LBLCA1
p.P177ABLCA1
p.T215ALGG1
p.K369NLUAD1
p.K339QSTAD1
p.E536KSKCM1
p.E414QCESC1
p.R29LHNSC1
p.M175IBLCA1
p.E515KUCEC1
p.S545LSKCM1
p.K488NBLCA1
p.E503KSKCM1
p.I19SHNSC1
p.S470FSKCM1
p.G482RSKCM1
p.E127*STAD1
p.R90QSKCM1
p.L15PCOAD1
p.T124ALIHC1
p.T238NLUAD1
p.E469KSKCM1
p.S415NLGG1
p.K444TLGG1
p.G299VLUSC1
p.K430NBLCA1
p.S463ISARC1
p.P330LSKCM1
p.G356ESKCM1
p.E276KSKCM1
p.S387FSKCM1
p.D499NSKCM1
p.E502VGBM1
p.E501QBLCA1
p.K532NLUAD1
p.G320RLUAD1
p.G452RSKCM1
p.T353MSKCM1
p.K489THNSC1
p.M372ISKCM1
p.G531ESKCM1
p.K287ILUAD1
p.G407RSKCM1
p.E276DSKCM1


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TissGeneCNV for C6orf10

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for C6orf10

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE089934FIBIN-C6orf10chr11:27016775chr6:3641779


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TissGeneNet for C6orf10

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for C6orf10

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for C6orf10
TissGeneDrug for C6orf10

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for C6orf10

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0003873Rheumatoid Arthritis5GAD,GWASCAT
umls:C0024141Lupus Erythematosus, Systemic3GAD
umls:C0026769Multiple Sclerosis3GAD,GWASCAT
umls:C0011854Diabetes Mellitus, Insulin-Dependent2GAD
umls:C0000786Spontaneous abortion1GAD
umls:C0003864Arthritis1GWASCAT
umls:C0004096Asthma1GAD,GWASCAT
umls:C0008312Primary biliary cirrhosis1GAD,GWASCAT
umls:C0010068Coronary heart disease1GWASCAT
umls:C0010346Crohn Disease1GAD
umls:C0011615Dermatitis, Atopic1GWASCAT
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1GAD
umls:C0018213Graves Disease1GAD,GWASCAT
umls:C0018799Heart Diseases1GAD
umls:C0020538Hypertensive disease1GAD
umls:C0022658Kidney Diseases1GWASCAT
umls:C0023434Chronic Lymphocytic Leukemia1GWASCAT
umls:C0033860Psoriasis1GAD
umls:C0036421Systemic Scleroderma1GWASCAT
umls:C0086445Idiopathic Membranous Glomerulonephritis1GWASCAT
umls:C0238065Biliary Cirrhosis, Secondary1GWASCAT
umls:C0409979Neonatal Systemic lupus erythematosus1BeFree
umls:C0860207Drug-Induced Liver Injury1GAD
umls:C1847540Azoospermia, Nonobstructive1BeFree
umls:C1956346Coronary Artery Disease1GAD
umls:C3495559Juvenile arthritis1GAD