TissGeneSummary for CSPG5 |
Gene summary |
Basic gene information | Gene symbol | CSPG5 |
Gene name | chondroitin sulfate proteoglycan 5 (neuroglycan C) | |
Synonyms | NGC | |
Cytomap | UCSC genome browser: 3p21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001206942.1, NM_001206943.1,NM_001206944.1,NM_001206945.1,NM_006574.3, | |
Description | acidic leucine-rich EGF-like domain-containing brain proteinchondroitin sulfate proteoglycan 5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606775 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114646 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CSPG5 | |
BioGPS: 10675 | ||
Pathway | NCI Pathway Interaction Database: CSPG5 | |
KEGG: CSPG5 | ||
REACTOME: CSPG5 | ||
Pathway Commons: CSPG5 | ||
Context | iHOP: CSPG5 | |
ligand binding site mutation search in PubMed: CSPG5 | ||
UCL Cancer Institute: CSPG5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of CSPG5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CSPG5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -0.508777666 | -2.613787666 | 2.10501 | 6.38E-13 | 1.32E-11 |
BLCA | -0.342404298 | -1.843920087 | 1.501515789 | 0.00607 | 0.030681091 |
KICH | -0.547439666 | -2.308547666 | 1.761108 | 0.000119 | 0.000306397 |
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TissGene-miRNA for CSPG5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CSPG5 |
TissGeneSNV for CSPG5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D119N | BLCA | 2 |
p.E534Q | BLCA | 1 |
p.S470F | READ | 1 |
p.K494N | UCEC | 1 |
p.T98A | STAD | 1 |
p.T452M | READ | 1 |
p.A164G | DLBC | 1 |
p.A42T | CESC | 1 |
p.P189T | LUAD | 1 |
p.T478A | LUAD | 1 |
p.I138M | UCEC | 1 |
p.L177Q | ESCA | 1 |
p.G356D | LGG | 1 |
p.R464W | STAD | 1 |
p.E481K | BLCA | 1 |
p.G385S | SARC | 1 |
p.G385D | COAD | 1 |
p.D211E | ACC | 1 |
p.Y380H | UCEC | 1 |
p.E148K | BLCA | 1 |
p.S379C | PAAD | 1 |
p.T496I | STAD | 1 |
p.E214K | HNSC | 1 |
p.S543L | SKCM | 1 |
p.E283K | UCEC | 1 |
p.D375N | BRCA | 1 |
p.D261N | STAD | 1 |
p.E533* | BLCA | 1 |
p.R458H | READ | 1 |
p.E166D | UCEC | 1 |
p.R411C | STAD | 1 |
p.I138V | GBM | 1 |
p.C359G | SKCM | 1 |
p.D119Y | BLCA | 1 |
p.L89M | COAD | 1 |
p.D472V | BRCA | 1 |
p.V390L | CESC | 1 |
p.L350* | SARC | 1 |
p.A518D | STAD | 1 |
p.D119N | CESC | 1 |
p.G181D | OV | 1 |
p.G107S | HNSC | 1 |
p.G427S | LGG | 1 |
p.T112A | UCEC | 1 |
p.R365W | PAAD | 1 |
p.I208N | HNSC | 1 |
p.G233R | LIHC | 1 |
p.L216P | PAAD | 1 |
p.T401M | LIHC | 1 |
p.E481K | UCEC | 1 |
p.S517N | LUAD | 1 |
p.E297K | HNSC | 1 |
p.A223T | PRAD | 1 |
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TissGeneCNV for CSPG5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CSPG5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF364648 | CSPG5-MAG | chr3:47614359 | chr19:35800990 |
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TissGeneNet for CSPG5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CSPG5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CSPG5 |
TissGeneDrug for CSPG5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CSPG5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011311 | Dengue Fever | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
umls:C0871189 | Psychotic symptom | 1 | BeFree |