TissGeneSummary for CEACAM7 |
Gene summary |
Basic gene information | Gene symbol | CEACAM7 |
Gene name | carcinoembryonic antigen-related cell adhesion molecule 7 | |
Synonyms | CEA|CGM2 | |
Cytomap | UCSC genome browser: 19q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001291485.1, NM_006890.4, | |
Description | carcinoembryonic antigen CGM2carcinoembryonic antigen gene family member 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000007306 | ||
HPRD : 07629 | ||
Vega : OTTHUMG00000151063 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CEACAM7 | |
BioGPS: 1087 | ||
Pathway | NCI Pathway Interaction Database: CEACAM7 | |
KEGG: CEACAM7 | ||
REACTOME: CEACAM7 | ||
Pathway Commons: CEACAM7 | ||
Context | iHOP: CEACAM7 | |
ligand binding site mutation search in PubMed: CEACAM7 | ||
UCL Cancer Institute: CEACAM7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
Reference showing the relevant tissue of CEACAM7 | ||
Description by TissGene annotations | Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CEACAM7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | 0.88883431 | 5.316136635 | -4.427302326 | 6.68E-09 | 8.64E-08 |
KIRC | -3.321683197 | -1.432245697 | -1.8894375 | 1.97E-26 | 2.71E-25 |
COAD | 6.135810607 | 11.8451683 | -5.709357692 | 1.26E-11 | 2.40E-10 |
LUAD | 0.479109811 | -1.524860879 | 2.00397069 | 2.81E-07 | 1.03E-06 |
BRCA | -0.398995331 | -1.507119015 | 1.108123684 | 3.64E-07 | 1.03E-06 |
LUSC | -0.450039242 | -1.532121595 | 1.082082353 | 0.00815 | 0.013185201 |
KIRP | -2.776690835 | -1.38339396 | -1.393296875 | 8.08E-05 | 0.000283053 |
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TissGene-miRNA for CEACAM7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CEACAM7 |
TissGeneSNV for CEACAM7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G81E | SKCM | 2 |
p.G70L | LUAD | 1 |
p.G261E | SKCM | 1 |
p.W180* | OV | 1 |
p.A206D | SARC | 1 |
p.E217K | BLCA | 1 |
p.N116D | COAD | 1 |
p.T207A | BLCA | 1 |
p.A251T | LUSC | 1 |
p.R78Q | SKCM | 1 |
p.Y236H | COAD | 1 |
p.N90Y | HNSC | 1 |
p.H74P | SKCM | 1 |
p.A75V | SKCM | 1 |
p.W67C | GBM | 1 |
p.E71K | HNSC | 1 |
p.N112S | LUAD | 1 |
p.T175S | LIHC | 1 |
p.L203I | BLCA | 1 |
p.A260T | UCEC | 1 |
p.R226H | GBM | 1 |
p.R78* | STAD | 1 |
p.Y140C | OV | 1 |
p.A95T | LGG | 1 |
p.V41M | COAD | 1 |
p.E217K | SKCM | 1 |
p.V188I | SKCM | 1 |
p.S227N | SKCM | 1 |
p.W28* | LUSC | 1 |
p.L201F | SKCM | 1 |
p.R10T | BLCA | 1 |
p.G70V | LUAD | 1 |
p.N32S | STAD | 1 |
p.N132H | LUAD | 1 |
p.R78* | SKCM | 1 |
p.A241S | UCEC | 1 |
p.A75S | BLCA | 1 |
p.G70W | LUAD | 1 |
p.A46T | CESC | 1 |
p.N198S | PRAD | 1 |
p.A22T | PRAD | 1 |
p.V131L | LUAD | 1 |
p.L178P | SKCM | 1 |
p.T114I | SKCM | 1 |
p.Q88K | STAD | 1 |
p.S3P | PAAD | 1 |
p.N154S | SKCM | 1 |
p.E71K | SKCM | 1 |
p.I211K | HNSC | 1 |
p.R226C | GBM | 1 |
p.I79N | HNSC | 1 |
p.R78X | STAD | 1 |
p.S59F | SKCM | 1 |
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TissGeneCNV for CEACAM7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CEACAM7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ326141 | CEACAM7-STIP1 | chr19:42191140 | chr11:63960700 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | HKR1-CEACAM7 | In-Frame | chr19:37838774 | chr19:42191152 |
TCGAfusionPortal | PRADA | BLCA | TCGA-DK-A3X2-01A | ZFP30-CEACAM7 | In-frame | Chr19:38135511 | Chr19:42191152 |
TCGAfusionPortal | PRADA | LGG | TCGA-P5-A5EU-01A | TSHZ3-CEACAM7 | In-frame | Chr19:31840086 | Chr19:42181431 |
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TissGeneNet for CEACAM7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CEACAM7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CEACAM7 |
TissGeneDrug for CEACAM7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CEACAM7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009402 | Colorectal Carcinoma | 47 | BeFree |
umls:C1527249 | Colorectal Cancer | 40 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 25 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 20 | BeFree |
umls:C0678222 | Breast Carcinoma | 20 | BeFree |
umls:C0699791 | Stomach Carcinoma | 16 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 15 | BeFree |
umls:C0007102 | Malignant tumor of colon | 12 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 12 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 12 | BeFree |
umls:C0699790 | Colon Carcinoma | 12 | BeFree |
umls:C0494165 | Secondary malignant neoplasm of liver | 10 | BeFree |
umls:C0001418 | Adenocarcinoma | 7 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 5 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 5 | BeFree |
umls:C0948380 | Colorectal cancer metastatic | 5 | BeFree |
umls:C0001430 | Adenoma | 4 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
umls:C0009375 | Colonic Neoplasms | 4 | BeFree |
umls:C0684249 | Carcinoma of lung | 4 | BeFree |
umls:C0007113 | Rectal Carcinoma | 3 | BeFree |
umls:C0019348 | Herpes Simplex Infections | 3 | BeFree |
umls:C0025500 | Mesothelioma | 3 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 3 | BeFree |
umls:C0238462 | Medullary carcinoma of thyroid | 3 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 3 | BeFree |
umls:C0521158 | Recurrent tumor | 3 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 2 | BeFree,LHGDN |
umls:C0025007 | Measles | 2 | BeFree |
umls:C0178874 | Tumor Progression | 2 | BeFree |
umls:C0278701 | Gastric Adenocarcinoma | 2 | BeFree |
umls:C0280100 | Solid tumour | 2 | BeFree |
umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 2 | BeFree |
umls:C0002793 | Anaplasia | 1 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0010709 | Cyst | 1 | BeFree |
umls:C0016169 | pathologic fistula | 1 | BeFree |
umls:C0016629 | Fowlpox | 1 | BeFree |
umls:C0017178 | Gastrointestinal Diseases | 1 | BeFree |
umls:C0018021 | Goiter | 1 | BeFree |
umls:C0021841 | Intestinal Neoplasms | 1 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0025269 | Multiple Endocrine Neoplasia Type 2b | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0032584 | polyps | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0035335 | Retinoblastoma | 1 | BeFree |
umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
umls:C0149978 | Adenocarcinoma of rectum | 1 | BeFree |
umls:C0151544 | Gastrointestinal carcinoma | 1 | BeFree |
umls:C0275524 | Coinfection | 1 | BeFree |
umls:C0276199 | Canarypox (disorder) | 1 | BeFree |
umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
umls:C0278689 | Ovarian epithelial cancer recurrent | 1 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0334595 | Ganglioneuromatosis | 1 | BeFree |
umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0854750 | Colorectal cancer recurrent | 1 | BeFree |
umls:C0887833 | Carcinoma, Pancreatic Ductal | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
umls:C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 1 | BeFree |
umls:C1520166 | Xenograft Model | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |