TissGeneSummary for CFHR3 |
Gene summary |
Basic gene information | Gene symbol | CFHR3 |
Gene name | complement factor H-related 3 | |
Synonyms | CFHL3|DOWN16|FHR-3|FHR3|HLF4 | |
Cytomap | UCSC genome browser: 1q32 | |
Type of gene | protein-coding | |
RefGenes | NM_001166624.1, NM_021023.5, | |
Description | H factor-like 4H factor-like protein 3complement factor H-related protein 3 | |
Modification date | 20141219 | |
dbXrefs | MIM : 605336 | |
HGNC : HGNC | ||
Ensembl : ENSG00000116785 | ||
HPRD : 05626 | ||
Vega : OTTHUMG00000035929 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CFHR3 | |
BioGPS: 10878 | ||
Pathway | NCI Pathway Interaction Database: CFHR3 | |
KEGG: CFHR3 | ||
REACTOME: CFHR3 | ||
Pathway Commons: CFHR3 | ||
Context | iHOP: CFHR3 | |
ligand binding site mutation search in PubMed: CFHR3 | ||
UCL Cancer Institute: CFHR3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CFHR3 | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CFHR3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | 1.585560747 | 0.27921191 | 1.306348837 | 1.20E-06 | 8.97E-06 |
KICH | -1.363557671 | -0.328489671 | -1.035068 | 2.11E-05 | 6.27E-05 |
LIHC | 7.719788329 | 10.59464433 | -2.874856 | 5.32E-07 | 3.04E-06 |
LUSC | 1.676756917 | 0.605786329 | 1.070970588 | 6.24E-06 | 1.45E-05 |
LUAD | 1.391929432 | 0.292931156 | 1.098998276 | 4.05E-07 | 1.43E-06 |
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TissGene-miRNA for CFHR3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CFHR3 |
TissGeneSNV for CFHR3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G284E | SKCM | 3 |
p.Q316* | SKCM | 2 |
p.Q316X | SKCM | 2 |
p.P241S | PCPG | 2 |
p.W134C | LUAD | 1 |
p.C302G | LUAD | 1 |
p.E170K | SKCM | 1 |
p.G64E | SKCM | 1 |
p.P90S | KIRC | 1 |
p.T294A | COAD | 1 |
p.R40K | STAD | 1 |
p.P90S | SKCM | 1 |
p.G133D | SKCM | 1 |
p.R139G | UCEC | 1 |
p.M275I | UCEC | 1 |
p.A113G | LUAD | 1 |
p.Q124* | LUAD | 1 |
p.Y242H | STAD | 1 |
p.D56N | CESC | 1 |
p.P231S | SKCM | 1 |
p.A46P | UCEC | 1 |
p.C129Y | LUAD | 1 |
p.T130M | LGG | 1 |
p.R102I | COAD | 1 |
p.E299K | SKCM | 1 |
p.R320Q | SKCM | 1 |
p.H30P | LGG | 1 |
p.N278D | LUAD | 1 |
p.R39H | STAD | 1 |
p.Y42* | UCEC | 1 |
p.E330K | UCEC | 1 |
p.R142H | STAD | 1 |
p.A123V | UCEC | 1 |
p.V127I | BLCA | 1 |
p.S314L | SKCM | 1 |
p.S63L | HNSC | 1 |
p.P262T | TGCT | 1 |
p.W197S | READ | 1 |
p.P90L | SKCM | 1 |
p.E273X | COAD | 1 |
p.W134R | LUAD | 1 |
p.V228L | PRAD | 1 |
p.C319S | LUAD | 1 |
p.G48E | SKCM | 1 |
p.R285K | SKCM | 1 |
p.R40T | LUAD | 1 |
p.E93K | SKCM | 1 |
p.K86* | SKCM | 1 |
p.T130M | BLCA | 1 |
p.I323L | KIRP | 1 |
p.K132N | CESC | 1 |
p.I171L | ESCA | 1 |
p.R288K | SKCM | 1 |
p.K103R | STAD | 1 |
p.E170G | UCEC | 1 |
p.P26S | SARC | 1 |
p.V112L | ACC | 1 |
p.V105A | BLCA | 1 |
p.K174E | STAD | 1 |
p.G188E | SKCM | 1 |
p.V143F | KIRC | 1 |
p.S233L | STAD | 1 |
p.S286R | LUAD | 1 |
p.F224I | LUAD | 1 |
p.P26S | SKCM | 1 |
p.R320Q | ESCA | 1 |
p.Q19H | UCEC | 1 |
p.S147X | COAD | 1 |
p.H115N | LUAD | 1 |
p.T130M | STAD | 1 |
p.S159Y | COAD | 1 |
p.N6S | STAD | 1 |
p.R39C | STAD | 1 |
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TissGeneCNV for CFHR3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CFHR3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CFHR3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CFHR3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CFHR3 |
TissGeneDrug for CFHR3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CFHR3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0242383 | Age related macular degeneration | 17 | BeFree,GAD,LHGDN |
umls:C2931788 | Atypical Hemolytic Uremic Syndrome | 9 | BeFree,CTD_human,GAD |
umls:C0017661 | IGA Glomerulonephritis | 3 | BeFree,CTD_human |
umls:C0019061 | Hemolytic-Uremic Syndrome | 3 | BeFree,LHGDN |
umls:C0025303 | Meningococcal Infections | 3 | BeFree,CTD_human,GAD,GWASCAT |
umls:C0017662 | Glomerulonephritis, Membranoproliferative | 1 | BeFree |
umls:C0018133 | Graft-vs-Host Disease | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0022658 | Kidney Diseases | 1 | BeFree |
umls:C0022661 | Kidney Failure, Chronic | 1 | BeFree |
umls:C0023343 | Leprosy | 1 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0268731 | Renal glomerular disease | 1 | BeFree |
umls:C0302810 | Uremia syndrome | 1 | BeFree |
umls:C1536085 | Geographic Atrophy | 1 | BeFree |
umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
umls:C1864205 | Macular Degeneration, Age-Related, 1 | 0 | CTD_human |
umls:C2749604 | HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 | 0 | ORPHANET |