TissGeneSummary for DBF4 |
Gene summary |
Basic gene information | Gene symbol | DBF4 |
Gene name | DBF4 zinc finger | |
Synonyms | ASK|CHIF|DBF4A|ZDBF1 | |
Cytomap | UCSC genome browser: 7q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_006716.3, | |
Description | DBF4 homologDBF4 zinc finger ADBF4-type zinc finger-containing protein 1activator of S phase kinasechiffon homolog Aprotein DBF4 homolog Azinc finger, DBF-type containing 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604281 | |
HGNC : HGNC | ||
Ensembl : ENSG00000006634 | ||
HPRD : 10371 | ||
Vega : OTTHUMG00000131034 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DBF4 | |
BioGPS: 10926 | ||
Pathway | NCI Pathway Interaction Database: DBF4 | |
KEGG: DBF4 | ||
REACTOME: DBF4 | ||
Pathway Commons: DBF4 | ||
Context | iHOP: DBF4 | |
ligand binding site mutation search in PubMed: DBF4 | ||
UCL Cancer Institute: DBF4 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DBF4 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DBF4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.223308215 | -1.600270284 | 1.376962069 | 5.43E-19 | 9.02E-18 |
BRCA | -0.182526515 | -1.22136862 | 1.038842105 | 4.75E-28 | 5.55E-27 |
KICH | -0.247689111 | -2.241497111 | 1.993808 | 4.72E-12 | 4.82E-11 |
COAD | 0.81062335 | -0.59134588 | 1.401969231 | 1.04E-13 | 3.56E-12 |
KIRP | -1.580899486 | -2.626449486 | 1.04555 | 5.46E-08 | 3.52E-07 |
STAD | 0.004525514 | -1.411011986 | 1.4155375 | 2.71E-10 | 2.77E-08 |
LUSC | 0.335995673 | -1.556145503 | 1.892141176 | 2.75E-31 | 1.55E-29 |
BLCA | 0.030698047 | -1.383570374 | 1.414268421 | 2.30E-07 | 1.07E-05 |
ESCA | 0.702153071 | -1.104628748 | 1.806781818 | 2.58E-06 | 0.000684498 |
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TissGene-miRNA for DBF4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DBF4 |
TissGeneSNV for DBF4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E595K | BLCA | 2 |
p.D328E | ESCA | 1 |
p.N322D | STAD | 1 |
p.G139R | LUAD | 1 |
p.A488T | LGG | 1 |
p.T510N | LGG | 1 |
p.D656H | BLCA | 1 |
p.E652Q | LUSC | 1 |
p.H120D | SARC | 1 |
p.H542D | SKCM | 1 |
p.R584* | OV | 1 |
p.L141I | STAD | 1 |
p.P119S | UCEC | 1 |
p.R584* | SKCM | 1 |
p.S118* | UCEC | 1 |
p.N156Y | LUAD | 1 |
p.G633D | SKCM | 1 |
p.H171Y | SKCM | 1 |
p.S245Y | UCEC | 1 |
p.M6L | STAD | 1 |
p.S381C | BLCA | 1 |
p.K579E | DLBC | 1 |
p.S381Y | READ | 1 |
p.R211I | READ | 1 |
p.S160L | SKCM | 1 |
p.R584* | SARC | 1 |
p.S525X | STAD | 1 |
p.P252S | SKCM | 1 |
p.E144K | HNSC | 1 |
p.L453V | LUAD | 1 |
p.G48E | STAD | 1 |
p.V255I | BLCA | 1 |
p.L462F | COAD | 1 |
p.K221N | LUSC | 1 |
p.I169S | SKCM | 1 |
p.E406Q | BLCA | 1 |
p.E466K | UCEC | 1 |
p.W47C | SARC | 1 |
p.D494Y | LUSC | 1 |
p.K564N | CESC | 1 |
p.V490L | PRAD | 1 |
p.K548N | SKCM | 1 |
p.Q227K | ACC | 1 |
p.F318C | COAD | 1 |
p.Y482C | ESCA | 1 |
p.S321G | BLCA | 1 |
p.R576L | ESCA | 1 |
p.R584X | SKCM | 1 |
p.F622L | UCEC | 1 |
p.S245Y | ESCA | 1 |
p.L453E | LUAD | 1 |
p.D620Y | READ | 1 |
p.L310I | UCEC | 1 |
p.N645K | HNSC | 1 |
p.N25S | HNSC | 1 |
p.L170I | UCEC | 1 |
p.S381Y | UCEC | 1 |
p.D656V | OV | 1 |
p.E601Q | LUSC | 1 |
p.E289D | BLCA | 1 |
p.K63Q | COAD | 1 |
p.E307K | KIRP | 1 |
p.Y233C | BLCA | 1 |
p.D82Y | UCEC | 1 |
p.S538G | LUAD | 1 |
p.L518V | ESCA | 1 |
p.C299F | LUAD | 1 |
p.R74Q | ACC | 1 |
p.L658P | UCEC | 1 |
p.T390I | LGG | 1 |
p.I83V | UCEC | 1 |
p.G356V | LGG | 1 |
p.L453Q | LUAD | 1 |
p.P119H | OV | 1 |
p.S155L | BLCA | 1 |
p.K577R | DLBC | 1 |
p.R101Q | BLCA | 1 |
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TissGeneCNV for DBF4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DBF4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for DBF4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DBF4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DBF4 |
TissGeneDrug for DBF4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DBF4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 2 | BeFree,LHGDN |
umls:C0151779 | Cutaneous Melanoma | 2 | BeFree |
umls:C0153252 | Systemic candidiasis | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0877445 | Candidemia | 1 | BeFree |
umls:C1609535 | Invasive Candidiasis | 1 | BeFree |