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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for STMN2
check button Gene summary
Basic gene informationGene symbolSTMN2
Gene namestathmin 2
SynonymsSCG10|SCGN10
CytomapUCSC genome browser: 8q21.13
Type of geneprotein-coding
RefGenesNM_001199214.1,
NM_007029.3,
Descriptionneuron-specific growth-associated proteinneuronal growth-associated protein (silencer element)stathmin-2stathmin-like 2superior cervical ganglia, neural specific 10superior cervical ganglion-10 protein
Modification date20141207
dbXrefs MIM : 600621
HGNC : HGNC
Ensembl : ENSG00000104435
HPRD : 09003
Vega : OTTHUMG00000164610
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STMN2
BioGPS: 11075
PathwayNCI Pathway Interaction Database: STMN2
KEGG: STMN2
REACTOME: STMN2
Pathway Commons: STMN2
ContextiHOP: STMN2
ligand binding site mutation search in PubMed: STMN2
UCL Cancer Institute: STMN2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Brain
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGG
Reference showing the relevant tissue of STMN2
Description by TissGene annotationsHave significant anti-correlated miRNA
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007026negative regulation of microtubule depolymerization18452648
GO:0010976positive regulation of neuron projection development18452648
GO:0010977negative regulation of neuron projection development18452648
GO:0031115negative regulation of microtubule polymerization18452648
GO:0031117positive regulation of microtubule depolymerization18452648
GO:1990090cellular response to nerve growth factor stimulus21215777
GO:0007026negative regulation of microtubule depolymerization18452648
GO:0010976positive regulation of neuron projection development18452648
GO:0010977negative regulation of neuron projection development18452648
GO:0031115negative regulation of microtubule polymerization18452648
GO:0031117positive regulation of microtubule depolymerization18452648
GO:1990090cellular response to nerve growth factor stimulus21215777


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TissGeneExp for STMN2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-1.101329043-3.5476629412.4463338987.47E-104.39E-09
COAD0.0147431224.170870045-4.1561269231.67E-102.22E-09
ESCA-3.2898858990.392568646-3.6824545450.00240.025059155
STAD-0.9896347630.955821487-1.945456250.004330.017235699
HNSC-3.214231565-1.948336216-1.2658953490.0005120.001907285


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TissGene-miRNA for STMN2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UVMhsa-miR-96-5pMIMAT00000950.0094-0.380


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TissGeneMut for STMN2
TissGeneSNV for STMN2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E133KSKCM2
p.M139ISKCM2
p.R156HSTAD1
p.M12VBLCA1
p.S80FLIHC1
p.R114XSTAD1
p.R30HKIRC1
p.E172KSKCM1
p.E66DSKCM1
p.R146CUCEC1
p.R114*STAD1
p.E55QACC1
p.E113QSKCM1
p.A49TOV1
p.S65LSKCM1
p.L71SLIHC1
p.R30SESCA1
p.A49SLUAD1
p.R69*UCEC1
p.E144KSKCM1
p.D78GLIHC1
p.K104NSKCM1
p.R110KSKCM1
p.A67TSKCM1
p.L58FLUSC1
p.E113KSKCM1
p.A131EESCA1
p.P63HCOAD1


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TissGeneCNV for STMN2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for STMN2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABP423639TOMM70A-STMN2chr3:100083893chr8:80577185
Chimerdb3.0ChiTaRsNABF963877STMN2-FAT1chr8:80577148chr4:187628005


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TissGeneNet for STMN2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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COAD (tumor)COAD (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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HNSC (tumor)HNSC (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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KICH (tumor)KICH (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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KIRC (tumor)KIRC (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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KIRP (tumor)KIRP (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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LIHC (tumor)LIHC (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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LUAD (tumor)LUAD (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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LUSC (tumor)LUSC (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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PRAD (tumor)PRAD (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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STAD (tumor)STAD (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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THCA (tumor)THCA (normal)
STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (tumor)STMN2, ONECUT1, TEX11, GPRASP2, CDK1, PRKACA, NGFR, MAPK3, EEF1A1, MAPK10, GPRASP1, CEP70, TRPC5, VOPP1, RGS6, RGS20, CCDC85A (normal)
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TissGeneProg for STMN2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for STMN2
TissGeneDrug for STMN2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for STMN2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0022336Creutzfeldt-Jakob disease2BeFree,GAD
umls:C0239946Fibrosis, Liver2BeFree
umls:C0376329New Variant Creutzfeldt-Jakob Disease2BeFree
umls:C2931859Acquired CJD2BeFree
umls:C0004135Ataxia Telangiectasia1BeFree
umls:C0013364Dysautonomia, Familial1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0085648Synovial Cyst1BeFree
umls:C0162534Prion Diseases1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C1258666Myxoid cyst1BeFree
umls:C1269683Major Depressive Disorder1GWASCAT
umls:C2936349Plaque, Amyloid1BeFree