 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for ANXA10 |
 Gene summary |
| Basic gene information | Gene symbol | ANXA10 |
| Gene name | annexin A10 | |
| Synonyms | ANX14 | |
| Cytomap | UCSC genome browser: 4q33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007193.4, | |
| Description | annexin 14annexin-10annexin-14 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608008 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000109511 | ||
| HPRD : 09724 | ||
| Vega : OTTHUMG00000161275 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANXA10 | |
| BioGPS: 11199 | ||
| Pathway | NCI Pathway Interaction Database: ANXA10 | |
| KEGG: ANXA10 | ||
| REACTOME: ANXA10 | ||
| Pathway Commons: ANXA10 | ||
| Context | iHOP: ANXA10 | |
| ligand binding site mutation search in PubMed: ANXA10 | ||
| UCL Cancer Institute: ANXA10 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of ANXA10 | Expression and prognostic significance of gastric-specific annexin A10 in diffuse- and intestinal-type gastric carcinoma. Lu SH, Chen YL, Shun CT, Lai JN, Peng SY, Lai PL, Hsu HC. J Gastroenterol Hepatol. 2011 Jan;26(1):90-7. doi: 10.1111/j.1440-1746.2010.06480.x. (pmid:21175800) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for ANXA10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 5.674826432 | 8.482022432 | -2.807196 | 9.00E-11 | 1.18E-09 |
| LUSC | -0.151296744 | -1.518506548 | 1.367209804 | 0.000702 | 0.001326262 |
| HNSC | 0.44397699 | -1.133974172 | 1.577951163 | 0.000169 | 0.000706784 |
| LUAD | -0.022917637 | -1.652900395 | 1.629982759 | 5.23E-05 | 0.000137203 |
| Top |
| TissGene-miRNA for ANXA10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for ANXA10 |
| TissGeneSNV for ANXA10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R292Q | SKCM | 2 |
| p.T188M | BLCA | 1 |
| p.C48G | PRAD | 1 |
| p.Y63C | HNSC | 1 |
| p.G166R | SKCM | 1 |
| p.P19H | UCEC | 1 |
| p.A318V | UCEC | 1 |
| p.A171V | UCEC | 1 |
| p.H261N | LUSC | 1 |
| p.G69W | SARC | 1 |
| p.R288Q | STAD | 1 |
| p.G32* | LUAD | 1 |
| p.F33C | READ | 1 |
| p.D5N | STAD | 1 |
| p.R246X | COAD | 1 |
| p.A171V | THYM | 1 |
| p.S306* | STAD | 1 |
| p.E182K | SKCM | 1 |
| p.M197R | SKCM | 1 |
| p.G64D | SARC | 1 |
| p.Y6C | COAD | 1 |
| p.M156V | COAD | 1 |
| p.R47H | READ | 1 |
| p.E291D | ESCA | 1 |
| p.P15S | SKCM | 1 |
| p.R288* | LGG | 1 |
| p.R47C | COAD | 1 |
| p.Y144H | UCS | 1 |
| p.L313R | SKCM | 1 |
| p.D224Y | KIRC | 1 |
| p.G9E | SKCM | 1 |
| p.G264S | SKCM | 1 |
| p.R65L | KIRC | 1 |
| p.Q31X | COAD | 1 |
| p.R272S | THYM | 1 |
| p.A315V | LIHC | 1 |
| p.M54I | SKCM | 1 |
| p.T45I | COAD | 1 |
| p.N157S | SKCM | 1 |
| p.M156I | SKCM | 1 |
| p.H261N | UCEC | 1 |
| p.Y204C | STAD | 1 |
| p.M21I | SKCM | 1 |
| p.G32E | SKCM | 1 |
| p.V239F | THYM | 1 |
| p.I198S | SKCM | 1 |
| p.G166E | SKCM | 1 |
| p.E109K | BRCA | 1 |
| p.A177E | OV | 1 |
| p.R292* | BLCA | 1 |
| p.D169Y | ESCA | 1 |
| p.R246* | UCEC | 1 |
| p.D281V | LUAD | 1 |
| p.S306X | STAD | 1 |
| p.D38N | LUAD | 1 |
| p.G28R | SKCM | 1 |
| p.V179A | KIRP | 1 |
| Top |
| TissGeneCNV for ANXA10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for ANXA10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1FL-01A | ANXA10-FAM198B | Out-of-frame | Chr4:169049316 | Chr4:159052164 |
| Top |
| TissGeneNet for ANXA10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for ANXA10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for ANXA10 |
| TissGeneDrug for ANXA10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for ANXA10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
| umls:C0032584 | polyps | 5 | BeFree |
| umls:C0001430 | Adenoma | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0521158 | Recurrent tumor | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C2732618 | Sessile Serrated Adenoma/Polyp | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C1333762 | Gastric Cardia Adenocarcinoma | 1 | BeFree |
| umls:C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C3472623 | Serrated adenocarcinoma | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |