TissGeneSummary for RBPJL |
Gene summary |
Basic gene information | Gene symbol | RBPJL |
Gene name | recombination signal binding protein for immunoglobulin kappa J region-like | |
Synonyms | RBPL|RBPSUHL|SUHL | |
Cytomap | UCSC genome browser: 20q13.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001281448.1, NM_001281449.1,NM_014276.3, | |
Description | recombining binding protein suppressor of hairless-like proteintranscription factor RBP-L | |
Modification date | 20141207 | |
dbXrefs | MIM : 616104 | |
HGNC : HGNC | ||
Ensembl : ENSG00000124232 | ||
HPRD : 10187 | ||
Vega : OTTHUMG00000033055 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RBPJL | |
BioGPS: 11317 | ||
Pathway | NCI Pathway Interaction Database: RBPJL | |
KEGG: RBPJL | ||
REACTOME: RBPJL | ||
Pathway Commons: RBPJL | ||
Context | iHOP: RBPJL | |
ligand binding site mutation search in PubMed: RBPJL | ||
UCL Cancer Institute: RBPJL | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of RBPJL | The human pancreas proteome defined by transcriptomics and antibody-based profiling. Danielsson A, Pontén F, Fagerberg L, Hallström BM, Schwenk JM, Uhlén M, Korsgren O, Lindskog C. PLoS One. 2014 Dec 29;9(12):e115421. doi: 10.1371/journal.pone.0115421. eCollection 2014 (pmid:25546435) go to article | |
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RBPJL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 0.199372248 | 1.208112873 | -1.008740625 | 0.00447 | 0.017636895 |
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TissGene-miRNA for RBPJL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RBPJL |
TissGeneSNV for RBPJL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R58C | STAD | 1 |
p.G260A | ESCA | 1 |
p.T249M | BRCA | 1 |
p.S480R | ESCA | 1 |
p.R222L | LUAD | 1 |
p.V278I | BLCA | 1 |
p.L499M | ESCA | 1 |
p.M457I | BLCA | 1 |
p.A341T | SKCM | 1 |
p.T249K | HNSC | 1 |
p.R222C | UCEC | 1 |
p.S196W | LUAD | 1 |
p.V269F | ESCA | 1 |
p.E149K | SKCM | 1 |
p.R229C | LIHC | 1 |
p.A153T | STAD | 1 |
p.R220L | OV | 1 |
p.E347* | HNSC | 1 |
p.H457N | HNSC | 1 |
p.R70W | HNSC | 1 |
p.E26D | UCEC | 1 |
p.P381L | CESC | 1 |
p.D34H | BLCA | 1 |
p.H185N | ESCA | 1 |
p.R86W | ESCA | 1 |
p.R270C | UCEC | 1 |
p.P483S | STAD | 1 |
p.V481A | DLBC | 1 |
p.Q516* | LGG | 1 |
p.V103M | GBM | 1 |
p.H18Q | GBM | 1 |
p.T507M | THYM | 1 |
p.D302H | BRCA | 1 |
p.S444R | DLBC | 1 |
p.A376V | STAD | 1 |
p.T116M | ESCA | 1 |
p.R168W | STAD | 1 |
p.P92S | UCEC | 1 |
p.R168W | UCEC | 1 |
p.S389N | CHOL | 1 |
p.H256Y | STAD | 1 |
p.A411V | ACC | 1 |
p.K293E | BLCA | 1 |
p.D235H | HNSC | 1 |
p.C65R | KIRC | 1 |
p.R222H | UCEC | 1 |
p.S211P | SKCM | 1 |
p.P92L | UCEC | 1 |
p.R508C | STAD | 1 |
p.G125V | KIRP | 1 |
p.L465F | SKCM | 1 |
p.G151S | BRCA | 1 |
p.R243X | COAD | 1 |
p.G363S | LGG | 1 |
p.R70Q | DLBC | 1 |
p.D261N | DLBC | 1 |
p.Q516K | HNSC | 1 |
p.P15S | SKCM | 1 |
p.R222C | READ | 1 |
p.E347K | SKCM | 1 |
p.E505K | SKCM | 1 |
p.G178S | BLCA | 1 |
p.L451V | BLCA | 1 |
p.V420M | CESC | 1 |
p.C434* | LUAD | 1 |
p.R465C | UCEC | 1 |
p.G40C | GBM | 1 |
p.R36L | BRCA | 1 |
p.K75T | STAD | 1 |
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TissGeneCNV for RBPJL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RBPJL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RBPJL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RBPJL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RBPJL |
TissGeneDrug for RBPJL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RBPJL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |