TissGeneSummary for CMTM1 |
Gene summary |
Basic gene information | Gene symbol | CMTM1 |
Gene name | CKLF-like MARVEL transmembrane domain containing 1 | |
Synonyms | CKLFH|CKLFH1|CKLFSF1 | |
Cytomap | UCSC genome browser: 16q21 | |
Type of gene | protein-coding | |
RefGenes | NM_052999.3, NM_181268.2,NM_181269.2,NM_181270.2,NM_181271.2, NM_181272.2,NM_181283.2,NM_181296.2,NM_181285.1, NM_181286.1,NM_181287.1,NM_181288.1,NM_181289.2, NM_181290.1,NM_181292.1,NM_181293.1,NM_181294.1, NM_181295.1,NM_181297.1,NM_181298.1,NM_181299.1, NM_181300.1,NM_181301.1, | |
Description | CKLF-like MARVEL transmembrane domain-containing protein 1chemokine-like factor super family 1chemokine-like factor superfamily 1chemokine-like factor superfamily member 1chemokine-like factor-like protein CKLFH1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607884 | |
HGNC : HGNC | ||
Ensembl : ENSG00000089505 | ||
HPRD : 07433 | ||
Vega : OTTHUMG00000137502 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CMTM1 | |
BioGPS: 113540 | ||
Pathway | NCI Pathway Interaction Database: CMTM1 | |
KEGG: CMTM1 | ||
REACTOME: CMTM1 | ||
Pathway Commons: CMTM1 | ||
Context | iHOP: CMTM1 | |
ligand binding site mutation search in PubMed: CMTM1 | ||
UCL Cancer Institute: CMTM1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CMTM1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CMTM1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.059331584 | -1.051877037 | 1.111208621 | 4.76E-13 | 3.84E-12 |
KIRP | -0.177187382 | -1.353818632 | 1.17663125 | 4.39E-08 | 2.91E-07 |
STAD | -0.156024882 | -1.188087382 | 1.0320625 | 2.45E-09 | 1.62E-07 |
ESCA | 0.485976254 | -1.327878291 | 1.813854545 | 0.000154 | 0.004390974 |
BLCA | -0.403466329 | -1.655561066 | 1.252094737 | 6.89E-05 | 0.000823837 |
Top |
TissGene-miRNA for CMTM1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CMTM1 |
TissGeneSNV for CMTM1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S151F | STAD | 1 |
p.V56F | LGG | 1 |
p.E264K | LUAD | 1 |
p.A25T | UCEC | 1 |
p.P282S | SKCM | 1 |
p.R130H | UCEC | 1 |
p.N160Y | BLCA | 1 |
p.L146F | BLCA | 1 |
p.I56M | LUSC | 1 |
p.S268F | SKCM | 1 |
p.A98V | STAD | 1 |
p.I56T | HNSC | 1 |
p.I173T | HNSC | 1 |
p.R252G | KIRC | 1 |
p.V114M | STAD | 1 |
p.E147K | LUAD | 1 |
p.L234V | LUAD | 1 |
p.P152L | STAD | 1 |
p.A76T | STAD | 1 |
p.P269S | LGG | 1 |
p.W76C | UCEC | 1 |
p.A67T | READ | 1 |
p.P269L | STAD | 1 |
p.S132F | LGG | 1 |
p.S134L | BLCA | 1 |
p.R284M | UCEC | 1 |
p.S268F | STAD | 1 |
p.Q62R | BLCA | 1 |
Top |
TissGeneCNV for CMTM1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CMTM1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CMTM1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CMTM1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CMTM1 |
TissGeneDrug for CMTM1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CMTM1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |