TissGeneSummary for RHPN1 |
Gene summary |
Basic gene information | Gene symbol | RHPN1 |
Gene name | rhophilin, Rho GTPase binding protein 1 | |
Synonyms | ODF5|RHOPHILIN|RHPN | |
Cytomap | UCSC genome browser: 8q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_052924.2, | |
Description | GTP-Rho-binding protein 1outer dense fiber of sperm tails 5rhophilin 1rhophilin-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601031 | |
HGNC : HGNC | ||
Ensembl : ENSG00000158106 | ||
HPRD : 17973 | ||
Vega : OTTHUMG00000165006 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RHPN1 | |
BioGPS: 114822 | ||
Pathway | NCI Pathway Interaction Database: RHPN1 | |
KEGG: RHPN1 | ||
REACTOME: RHPN1 | ||
Pathway Commons: RHPN1 | ||
Context | iHOP: RHPN1 | |
ligand binding site mutation search in PubMed: RHPN1 | ||
UCL Cancer Institute: RHPN1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | StomachThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STADTHCA | |
Reference showing the relevant tissue of RHPN1 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for RHPN1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -0.285923612 | -1.721193612 | 1.43527 | 7.42E-08 | 5.35E-07 |
BRCA | 1.923385897 | 0.01741923 | 1.905966667 | 4.93E-25 | 4.92E-24 |
COAD | 1.355097772 | -1.273282997 | 2.628380769 | 4.56E-14 | 1.69E-12 |
LUAD | 1.39088756 | 0.350432388 | 1.040455172 | 2.15E-09 | 1.09E-08 |
STAD | 1.059873013 | -0.696417612 | 1.756290625 | 1.38E-09 | 1.07E-07 |
BLCA | 1.764882388 | -0.364417612 | 2.1293 | 0.000231 | 0.002195487 |
Top |
TissGene-miRNA for RHPN1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for RHPN1 |
TissGeneSNV for RHPN1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E378K | READ | 1 |
p.R617K | SKCM | 1 |
p.R446H | STAD | 1 |
p.K118N | LUSC | 1 |
p.R483H | CESC | 1 |
p.P670Q | LUAD | 1 |
p.R483H | STAD | 1 |
p.S447* | ESCA | 1 |
p.G522S | UCEC | 1 |
p.L534F | SKCM | 1 |
p.Q642* | SKCM | 1 |
p.R51W | LGG | 1 |
p.W628C | LUAD | 1 |
p.C287Y | READ | 1 |
p.W565C | LUAD | 1 |
p.S594C | ESCA | 1 |
p.V344M | GBM | 1 |
p.R456H | STAD | 1 |
p.Q206R | COAD | 1 |
p.E319G | BLCA | 1 |
p.R518Q | SKCM | 1 |
p.E286K | SKCM | 1 |
p.A581V | LUAD | 1 |
p.I110F | SKCM | 1 |
p.W565R | BLCA | 1 |
p.G366D | LIHC | 1 |
p.G94D | BLCA | 1 |
p.A71T | CESC | 1 |
p.F460L | KICH | 1 |
p.T443A | COAD | 1 |
p.R146G | LUAD | 1 |
p.G519V | SKCM | 1 |
p.S447X | ESCA | 1 |
p.E136K | CESC | 1 |
p.P650S | SKCM | 1 |
p.E551D | COAD | 1 |
p.S594F | UCEC | 1 |
p.S626C | ESCA | 1 |
p.P660L | THYM | 1 |
p.Q445* | STAD | 1 |
p.R308C | READ | 1 |
p.W669L | LUAD | 1 |
p.G190R | COAD | 1 |
p.A578T | DLBC | 1 |
p.T52M | COAD | 1 |
p.A536T | PAAD | 1 |
p.R325Q | BLCA | 1 |
p.Q445X | STAD | 1 |
p.A578V | SKCM | 1 |
p.R51W | BLCA | 1 |
p.P670L | HNSC | 1 |
p.V77I | COAD | 1 |
p.T69M | UCEC | 1 |
p.K550N | LUSC | 1 |
p.A54T | STAD | 1 |
Top |
TissGeneCNV for RHPN1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for RHPN1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for RHPN1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for RHPN1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for RHPN1 |
TissGeneDrug for RHPN1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for RHPN1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |