TissGeneSummary for PNMA5 |
Gene summary |
Basic gene information | Gene symbol | PNMA5 |
Gene name | paraneoplastic Ma antigen family member 5 | |
Synonyms | - | |
Cytomap | UCSC genome browser: Xq28 | |
Type of gene | protein-coding | |
RefGenes | NM_001103150.1, NM_001103151.1,NM_001184924.1,NM_052926.2, | |
Description | paraneoplastic antigen-like protein 5tumor antigen BJ-HCC-25 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300916 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198883 | ||
HPRD : 06678 | ||
Vega : OTTHUMG00000024184 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PNMA5 | |
BioGPS: 114824 | ||
Pathway | NCI Pathway Interaction Database: PNMA5 | |
KEGG: PNMA5 | ||
REACTOME: PNMA5 | ||
Pathway Commons: PNMA5 | ||
Context | iHOP: PNMA5 | |
ligand binding site mutation search in PubMed: PNMA5 | ||
UCL Cancer Institute: PNMA5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PNMA5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PNMA5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.71172264 | -0.340053831 | 1.051776471 | 0.0176 | 0.026708356 |
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TissGene-miRNA for PNMA5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PNMA5 |
TissGeneSNV for PNMA5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E434K | SKCM | 2 |
p.P443L | THYM | 1 |
p.R326Q | SKCM | 1 |
p.M322I | HNSC | 1 |
p.A301S | UCEC | 1 |
p.R288C | HNSC | 1 |
p.H275L | LUSC | 1 |
p.P424T | CESC | 1 |
p.E90K | BRCA | 1 |
p.R213Q | CESC | 1 |
p.G313W | LGG | 1 |
p.E68* | BLCA | 1 |
p.P130S | SKCM | 1 |
p.E172K | UCEC | 1 |
p.L231R | LUSC | 1 |
p.E172* | LUAD | 1 |
p.R282C | UCEC | 1 |
p.A371T | PAAD | 1 |
p.P170Q | OV | 1 |
p.S163L | READ | 1 |
p.R282C | STAD | 1 |
p.R326* | SKCM | 1 |
p.S163L | SKCM | 1 |
p.Q141P | SARC | 1 |
p.P316S | KICH | 1 |
p.R199H | UCS | 1 |
p.G171C | LUAD | 1 |
p.P150S | LUAD | 1 |
p.D16N | SKCM | 1 |
p.S398R | PRAD | 1 |
p.L269M | LUAD | 1 |
p.F56Y | UCS | 1 |
p.S163L | UCEC | 1 |
p.E172K | SKCM | 1 |
p.V369M | UCEC | 1 |
p.G385C | LUAD | 1 |
p.H275Q | LUAD | 1 |
p.R295Q | STAD | 1 |
p.R213W | GBM | 1 |
p.R288H | THCA | 1 |
p.P278T | LUSC | 1 |
p.A2T | UCEC | 1 |
p.E59K | SKCM | 1 |
p.E257Q | HNSC | 1 |
p.A414T | LUSC | 1 |
p.I67T | BLCA | 1 |
p.A230T | STAD | 1 |
p.R288H | PAAD | 1 |
p.R326X | SKCM | 1 |
p.R288H | LGG | 1 |
p.A336T | UCEC | 1 |
p.S116R | LIHC | 1 |
p.D310N | SKCM | 1 |
p.P387L | UCEC | 1 |
p.G432E | SKCM | 1 |
p.A439V | STAD | 1 |
p.Q366* | HNSC | 1 |
p.R326* | UCEC | 1 |
p.S244Y | HNSC | 1 |
p.R282C | COAD | 1 |
p.I82V | UCEC | 1 |
p.G86D | STAD | 1 |
p.S144T | HNSC | 1 |
p.D37G | UCEC | 1 |
p.W189X | COAD | 1 |
p.G164E | SKCM | 1 |
p.M440I | SKCM | 1 |
p.P268H | LUAD | 1 |
p.G423R | STAD | 1 |
p.S244C | ACC | 1 |
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TissGeneCNV for PNMA5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PNMA5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BX390177 | PNMA5-PPP1R18 | chrX:152159764 | chr6:1976470 | |
Chimerdb3.0 | ChiTaRs | NA | BX392220 | PPP1R18-PNMA5 | chr6:1976835 | chrX:152159705 |
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TissGeneNet for PNMA5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PNMA5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PNMA5 |
TissGeneDrug for PNMA5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PNMA5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |