TissGeneSummary for CCDC151 |
Gene summary |
Basic gene information | Gene symbol | CCDC151 |
Gene name | coiled-coil domain containing 151 | |
Synonyms | CILD30 | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001302453.1, NM_001302454.1,NM_145045.4, | |
Description | coiled-coil domain-containing protein 151 | |
Modification date | 20141207 | |
dbXrefs | MIM : 615956 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198003 | ||
HPRD : 10076 | ||
Vega : OTTHUMG00000182028 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC151 | |
BioGPS: 115948 | ||
Pathway | NCI Pathway Interaction Database: CCDC151 | |
KEGG: CCDC151 | ||
REACTOME: CCDC151 | ||
Pathway Commons: CCDC151 | ||
Context | iHOP: CCDC151 | |
ligand binding site mutation search in PubMed: CCDC151 | ||
UCL Cancer Institute: CCDC151 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of CCDC151 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC151 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.366821507 | -2.435371507 | 1.06855 | 2.18E-08 | 6.98E-08 |
LUSC | -1.639333942 | 0.450260175 | -2.089594118 | 2.22E-08 | 6.75E-08 |
LUAD | -1.092812644 | 0.522823563 | -1.615636207 | 2.15E-05 | 6.03E-05 |
KIRC | -0.876258861 | 0.677709195 | -1.553968056 | 4.51E-18 | 2.96E-17 |
KICH | 4.578894528 | 1.408858528 | 3.170036 | 2.43E-10 | 1.75E-09 |
KIRP | -0.375148097 | 1.035001903 | -1.41015 | 2.63E-07 | 1.49E-06 |
PRAD | -2.413424779 | -1.377411318 | -1.036013462 | 3.07E-05 | 0.000148593 |
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TissGene-miRNA for CCDC151 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC151 |
TissGeneSNV for CCDC151 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H68Q | UCEC | 1 |
p.M238I | SKCM | 1 |
p.E356Q | LUAD | 1 |
p.N528S | HNSC | 1 |
p.E298K | SKCM | 1 |
p.A47E | LIHC | 1 |
p.E271Q | ESCA | 1 |
p.E568* | PRAD | 1 |
p.W48X | SKCM | 1 |
p.V229M | UCEC | 1 |
p.R324C | STAD | 1 |
p.W48* | SKCM | 1 |
p.E287Q | BRCA | 1 |
p.G360D | PAAD | 1 |
p.R207W | SKCM | 1 |
p.R60T | BLCA | 1 |
p.R174Q | COAD | 1 |
p.P65H | LUSC | 1 |
p.R401T | LUSC | 1 |
p.A166T | STAD | 1 |
p.E194Q | HNSC | 1 |
p.E245Q | BRCA | 1 |
p.E134K | STAD | 1 |
p.K76T | UCEC | 1 |
p.S331F | LUAD | 1 |
p.Q217H | OV | 1 |
p.E560K | CESC | 1 |
p.E201D | LUSC | 1 |
p.H586D | BLCA | 1 |
p.I358F | SKCM | 1 |
p.H68Q | STAD | 1 |
p.R299C | STAD | 1 |
p.N567S | STAD | 1 |
p.P140Q | STAD | 1 |
p.K392N | BLCA | 1 |
p.E309K | COAD | 1 |
p.E287Q | BLCA | 1 |
p.E568K | BLCA | 1 |
p.K588R | COAD | 1 |
p.M318V | BLCA | 1 |
p.A87T | BLCA | 1 |
p.P50S | DLBC | 1 |
p.S595F | SKCM | 1 |
p.I132F | LUAD | 1 |
p.G56E | CESC | 1 |
p.R207Q | STAD | 1 |
p.E303Q | ESCA | 1 |
p.R207W | UCEC | 1 |
p.E436K | MESO | 1 |
p.R324H | PAAD | 1 |
p.K77N | UCEC | 1 |
p.T227S | KIRC | 1 |
p.K139R | HNSC | 1 |
p.N543S | COAD | 1 |
p.K28N | HNSC | 1 |
p.T49I | BLCA | 1 |
p.R593W | COAD | 1 |
p.R207W | THYM | 1 |
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TissGeneCNV for CCDC151 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC151 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BM800810 | RANGAP1-CCDC151 | chr22:41682192 | chr19:11531796 | |
TCGAfusionPortal | PRADA | LUAD | TCGA-MP-A5C7-01A | KRI1-CCDC151 | In-frame | Chr19:10670035 | Chr19:11534698 |
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TissGeneNet for CCDC151 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC151 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC151 |
TissGeneDrug for CCDC151 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC151 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0008780 | Ciliary Motility Disorders | 2 | BeFree |
umls:C0022521 | Kartagener Syndrome | 2 | BeFree,CLINVAR |
umls:C0018798 | Congenital Heart Defects | 1 | BeFree |
umls:C4015016 | CILIARY DYSKINESIA, PRIMARY, 30 | 0 | MGD |