TissGeneSummary for SLC22A12 |
Gene summary |
Basic gene information | Gene symbol | SLC22A12 |
Gene name | solute carrier family 22 (organic anion/urate transporter), member 12 | |
Synonyms | OAT4L|RST|URAT1 | |
Cytomap | UCSC genome browser: 11q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001276326.1, NM_001276327.1,NM_144585.3,NM_153378.2, | |
Description | organic anion transporter 4-like proteinrenal-specific transportersolute carrier family 22 (organic anion/cation transporter), member 12solute carrier family 22 member 12urate anion exchanger 1urate transporter 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607096 | |
HGNC : HGNC | ||
Ensembl : ENSG00000197891 | ||
HPRD : 06160 | ||
Vega : OTTHUMG00000045213 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC22A12 | |
BioGPS: 116085 | ||
Pathway | NCI Pathway Interaction Database: SLC22A12 | |
KEGG: SLC22A12 | ||
REACTOME: SLC22A12 | ||
Pathway Commons: SLC22A12 | ||
Context | iHOP: SLC22A12 | |
ligand binding site mutation search in PubMed: SLC22A12 | ||
UCL Cancer Institute: SLC22A12 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC22A12 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0015747 | urate transport | 12024214 | GO:0042493 | response to drug | 12024214 | GO:0015747 | urate transport | 12024214 | GO:0042493 | response to drug | 12024214 |
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TissGeneExp for SLC22A12 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 4.771298042 | 7.298936931 | -2.527638889 | 1.16E-05 | 2.70E-05 |
KICH | -1.833792403 | 6.780867597 | -8.61466 | 1.93E-13 | 2.59E-12 |
BRCA | -2.421138508 | -0.186686754 | -2.234451754 | 2.46E-22 | 2.08E-21 |
KIRP | 4.021737972 | 9.062531722 | -5.04079375 | 2.09E-08 | 1.49E-07 |
LIHC | 1.454929597 | -0.575350403 | 2.03028 | 0.00209 | 0.005317171 |
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TissGene-miRNA for SLC22A12 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC22A12 |
TissGeneSNV for SLC22A12 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D140H | BLCA | 2 |
p.S276C | BLCA | 1 |
p.A416V | CHOL | 1 |
p.G164D | STAD | 1 |
p.R90S | LUAD | 1 |
p.R15M | LUAD | 1 |
p.S329N | UCEC | 1 |
p.D370N | SKCM | 1 |
p.M214I | BLCA | 1 |
p.R89H | PAAD | 1 |
p.S17Y | READ | 1 |
p.A195V | COAD | 1 |
p.C88F | LUAD | 1 |
p.R477H | LUAD | 1 |
p.R342C | SARC | 1 |
p.T217M | CESC | 1 |
p.M214I | UCEC | 1 |
p.L24V | BLCA | 1 |
p.G295S | SKCM | 1 |
p.E237K | COAD | 1 |
p.L320F | THYM | 1 |
p.E409K | ACC | 1 |
p.A190T | COAD | 1 |
p.S457R | LUAD | 1 |
p.P334S | HNSC | 1 |
p.A411P | CESC | 1 |
p.A191D | LUAD | 1 |
p.G541D | UCEC | 1 |
p.W495C | KIRC | 1 |
p.Q20H | LUAD | 1 |
p.A422V | STAD | 1 |
p.L239V | BLCA | 1 |
p.R228Q | LUAD | 1 |
p.G333R | SKCM | 1 |
p.P78Q | LUSC | 1 |
p.H540Y | BLCA | 1 |
p.A422D | LUAD | 1 |
p.T113M | HNSC | 1 |
p.Y152N | LUAD | 1 |
p.T467M | SKCM | 1 |
p.S179N | UCEC | 1 |
p.G441R | SKCM | 1 |
p.A160T | BLCA | 1 |
p.D112Y | MESO | 1 |
p.V10M | STAD | 1 |
p.K536N | LUSC | 1 |
p.A193D | LUSC | 1 |
p.E517K | ACC | 1 |
p.V132L | LIHC | 1 |
p.L521* | LUAD | 1 |
p.D262N | SKCM | 1 |
p.G470V | THYM | 1 |
p.E110K | BLCA | 1 |
p.T104M | STAD | 1 |
p.R48C | SKCM | 1 |
p.W57R | COAD | 1 |
p.A411T | UCEC | 1 |
p.R114H | UCEC | 1 |
p.R347S | SKCM | 1 |
p.R92H | PAAD | 1 |
p.D112N | STAD | 1 |
p.Q182H | LUAD | 1 |
p.R89L | ESCA | 1 |
p.A480V | STAD | 1 |
p.G366S | STAD | 1 |
p.S141P | BLCA | 1 |
p.T113R | HNSC | 1 |
p.R406H | LGG | 1 |
p.A416V | HNSC | 1 |
p.V302M | SKCM | 1 |
p.A111D | LUAD | 1 |
p.G470V | LUAD | 1 |
p.V138M | BLCA | 1 |
p.S242N | SKCM | 1 |
p.D100N | SKCM | 1 |
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TissGeneCNV for SLC22A12 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC22A12 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC22A12 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC22A12 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC22A12 |
TissGeneDrug for SLC22A12 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB11560 | Lesinurad | Inhibitor | Small molecule | Approved |
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TissGeneDisease for SLC22A12 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0473219 | Renal hypouricemia | 24 | BeFree,CLINVAR,CTD_human,UNIPROT |
umls:C0740394 | Hyperuricemia | 12 | BeFree,GAD |
umls:C0018099 | Gout | 5 | GAD |
umls:C0022660 | Kidney Failure, Acute | 5 | BeFree |
umls:C0149896 | Primary gout | 3 | BeFree |
umls:C0022658 | Kidney Diseases | 2 | GAD |
umls:C0392525 | Nephrolithiasis | 2 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 2 | BeFree |
umls:C3160858 | Posterior reversible encephalopathy syndrome | 2 | BeFree |
umls:C0003868 | Arthritis, Gouty | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0024530 | Malaria | 1 | BeFree |
umls:C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 1 | BeFree |
umls:C0700634 | Serum uric acid observed | 1 | GAD |
umls:C2609414 | Acute kidney injury | 1 | CTD_human |
umls:C2919861 | Medullary cystic kidney disease type 1 | 1 | BeFree |